Dinuclear copper(II) complexes of Fenoprofen: Synthesis, spectroscopic, thermal, and SOD-mimic activity studies
Three dinuclear copper(II) complexes with the anti-inflammatory drug Fenoprofen [Hfen, 2-(3-phenoxyphenyl)propionic acid] and nitrogen donors of general formula [Cu2(fen)4(L)]n were prepared from [Cu2(fen)4(dmf)2]2H 2O (1) [dmf = N,N'-dimethylformamide; L = 4,4'-bipyridine (2), pyrazine (3...
| Autores: | , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2011 |
| País: | Argentina |
| Institución: | Consejo Nacional de Investigaciones Científicas y Técnicas |
| Repositorio: | CONICET Digital (CONICET) |
| Idioma: | inglés |
| OAI Identifier: | oai:ri.conicet.gov.ar:11336/64702 |
| Acceso en línea: | http://hdl.handle.net/11336/64702 |
| Access Level: | acceso abierto |
| Palabra clave: | Anti-Inflammatory Copper Fenoprofen Sod Spectroscopy https://purl.org/becyt/ford/1.4 https://purl.org/becyt/ford/1 |
| Sumario: | Three dinuclear copper(II) complexes with the anti-inflammatory drug Fenoprofen [Hfen, 2-(3-phenoxyphenyl)propionic acid] and nitrogen donors of general formula [Cu2(fen)4(L)]n were prepared from [Cu2(fen)4(dmf)2]2H 2O (1) [dmf = N,N'-dimethylformamide; L = 4,4'-bipyridine (2), pyrazine (3), and 2,5-dimethylpyrazine (4)]. The new complexes were characterized by chemical analysis, spectroscopic, and thermogravimetric techniques. Antioxidant properties of 1-4 were evaluated for superoxide-dismutase-mimic activity employing the XTT method. Complex 2 presented the highest antioxidant activity (IC50 = 0.260 mol L-1). Anti-inflammatory properties of 2 were evaluated employing carrageenan-induced paw edema in mice, revealing that the Fenoprofen-copper(II) complex containing 4,4'-bipyridine does not present enhanced anti-inflammatory activity compared to the uncomplexed parent drug Fenoprofen calcium salt. © 2011 Taylor & Francis. |
|---|