Experimental autoimmune orchitis as a model of immunological male infertility

Clinically, 60-75% of male infertility cases are categorized as idiopathic spermatogenic disturbance. In previous studies of this condition, lymphocytic infiltration and immune deposits were present in several testis biopsy specimens, indicating that inflammatory or immunological factors contribute...

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Detalles Bibliográficos
Autores: Naito, Munekazu, Terayama, Hayato, Hirai, Shuichi, Qu, Ning, Lustig, Livia, Itoh, Masahiro
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2012
País:Argentina
Institución:Consejo Nacional de Investigaciones Científicas y Técnicas
Repositorio:CONICET Digital (CONICET)
Idioma:inglés
OAI Identifier:oai:ri.conicet.gov.ar:11336/67312
Acceso en línea:http://hdl.handle.net/11336/67312
Access Level:acceso abierto
Palabra clave:Testis
Blood Testis Barrier
Autoimmunity
Orchitis
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
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spelling Experimental autoimmune orchitis as a model of immunological male infertilityNaito, MunekazuTerayama, HayatoHirai, ShuichiQu, NingLustig, LiviaItoh, MasahiroTestisBlood Testis BarrierAutoimmunityOrchitishttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Clinically, 60-75% of male infertility cases are categorized as idiopathic spermatogenic disturbance. In previous studies of this condition, lymphocytic infiltration and immune deposits were present in several testis biopsy specimens, indicating that inflammatory or immunological factors contribute to the occurrence of the lesions. However, there is currently little evidence regarding immunological infertility in men. Previously, we established an immunological infertility model, experimental autoimmune orchitis (EAO), that can be induced in mice by two subcutaneous injections of viable syngeneic testicular germ cells without the use of any adjuvant. In this EAO model, lymphocytes surround the tubuli recti and then induce spermatogenic disturbance. In addition, after the active inflammation stage of this model, the seminiferous epithelium is damaged irreversibly, resembling the histopathology of human male idiopathic spermatogenic disturbance. In the majority of patients with testicular autoimmunity, there is a chronic and asymptomatic development of the inflammatory reaction. Therefore, this disease is very difficult to diagnose at the ongoing stage, and it is possible that the histopathology of idiopathic spermatogenic disturbance in the clinic is reported at the post-active inflammation stage of autoimmune orchitis. In this review, the histopathology of EAO before and after inflammation is discussed, comparing it with human orchitis.Fil: Naito, Munekazu. Tokyo Medical University; JapónFil: Terayama, Hayato. Tokyo Medical University; JapónFil: Hirai, Shuichi. Tokyo Medical University; JapónFil: Qu, Ning. Tokyo Medical University; JapónFil: Lustig, Livia. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Biología Celular e Histología. Centro de Investigación en Reproducción; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Itoh, Masahiro. Tokyo Medical University; JapónSpringer Tokyo2012-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/67312Naito, Munekazu; Terayama, Hayato; Hirai, Shuichi; Qu, Ning; Lustig, Livia; et al.; Experimental autoimmune orchitis as a model of immunological male infertility; Springer Tokyo; Medical Molecular Morphology; 45; 4; 12-2012; 185-1891860-14801860-1499CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1007/s00795-012-0587-2info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007%2Fs00795-012-0587-2info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2024-05-08T13:57:18Zoai:ri.conicet.gov.ar:11336/67312instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982024-05-08 13:57:18.691CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Experimental autoimmune orchitis as a model of immunological male infertility
title Experimental autoimmune orchitis as a model of immunological male infertility
spellingShingle Experimental autoimmune orchitis as a model of immunological male infertility
Naito, Munekazu
Testis
Blood Testis Barrier
Autoimmunity
Orchitis
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
title_short Experimental autoimmune orchitis as a model of immunological male infertility
title_full Experimental autoimmune orchitis as a model of immunological male infertility
title_fullStr Experimental autoimmune orchitis as a model of immunological male infertility
title_full_unstemmed Experimental autoimmune orchitis as a model of immunological male infertility
title_sort Experimental autoimmune orchitis as a model of immunological male infertility
dc.creator.none.fl_str_mv Naito, Munekazu
Terayama, Hayato
Hirai, Shuichi
Qu, Ning
Lustig, Livia
Itoh, Masahiro
author Naito, Munekazu
author_facet Naito, Munekazu
Terayama, Hayato
Hirai, Shuichi
Qu, Ning
Lustig, Livia
Itoh, Masahiro
author_role author
author2 Terayama, Hayato
Hirai, Shuichi
Qu, Ning
Lustig, Livia
Itoh, Masahiro
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Testis
Blood Testis Barrier
Autoimmunity
Orchitis
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
topic Testis
Blood Testis Barrier
Autoimmunity
Orchitis
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
description Clinically, 60-75% of male infertility cases are categorized as idiopathic spermatogenic disturbance. In previous studies of this condition, lymphocytic infiltration and immune deposits were present in several testis biopsy specimens, indicating that inflammatory or immunological factors contribute to the occurrence of the lesions. However, there is currently little evidence regarding immunological infertility in men. Previously, we established an immunological infertility model, experimental autoimmune orchitis (EAO), that can be induced in mice by two subcutaneous injections of viable syngeneic testicular germ cells without the use of any adjuvant. In this EAO model, lymphocytes surround the tubuli recti and then induce spermatogenic disturbance. In addition, after the active inflammation stage of this model, the seminiferous epithelium is damaged irreversibly, resembling the histopathology of human male idiopathic spermatogenic disturbance. In the majority of patients with testicular autoimmunity, there is a chronic and asymptomatic development of the inflammatory reaction. Therefore, this disease is very difficult to diagnose at the ongoing stage, and it is possible that the histopathology of idiopathic spermatogenic disturbance in the clinic is reported at the post-active inflammation stage of autoimmune orchitis. In this review, the histopathology of EAO before and after inflammation is discussed, comparing it with human orchitis.
publishDate 2012
dc.date.none.fl_str_mv 2012-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/67312
Naito, Munekazu; Terayama, Hayato; Hirai, Shuichi; Qu, Ning; Lustig, Livia; et al.; Experimental autoimmune orchitis as a model of immunological male infertility; Springer Tokyo; Medical Molecular Morphology; 45; 4; 12-2012; 185-189
1860-1480
1860-1499
CONICET Digital
CONICET
url http://hdl.handle.net/11336/67312
identifier_str_mv Naito, Munekazu; Terayama, Hayato; Hirai, Shuichi; Qu, Ning; Lustig, Livia; et al.; Experimental autoimmune orchitis as a model of immunological male infertility; Springer Tokyo; Medical Molecular Morphology; 45; 4; 12-2012; 185-189
1860-1480
1860-1499
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1007/s00795-012-0587-2
info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007%2Fs00795-012-0587-2
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Springer Tokyo
publisher.none.fl_str_mv Springer Tokyo
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 15.811543

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