Distinct Mechanisms of Dissemination of NDM-1 Metallo-β-Lactamase in Acinetobacter Species in Argentina

A 4-year surveillance of carbapenem-resistant Acinetobacter spp. isolates in Argentina identified 40 strains carrying blaNDM-1. Genome sequencing revealed that most were Acinetobacter baumannii, whereas seven represented other Acinetobacter spp. The A. baumannii genomes were closely related, suggest...

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Detalles Bibliográficos
Autores: Adams, Mark D., Pasteran, Fernando, Traglia, German Matias, Martinez, Jasmine, Huang, Fanny, Liu, Christine, Fernandez, Jennifer, López, María Carolina, Gonzalez, Lisandro Javier, Albornoz, Ezequiel Pablo, Corso, Alejandra, Vila, Alejandro Jose, Bonomo, Robert A., Ramirez, Maria Soledad
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2020
País:Argentina
Institución:Consejo Nacional de Investigaciones Científicas y Técnicas
Repositorio:CONICET Digital (CONICET)
Idioma:inglés
OAI Identifier:oai:ri.conicet.gov.ar:11336/184743
Acceso en línea:http://hdl.handle.net/11336/184743
Access Level:acceso abierto
Palabra clave:ACINETOBACTER
ACINETOBACTER BAUMANNII
CARBAPENEM RESISTANCE
CARBAPENEMS
NDM-1
https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
Descripción
Sumario:A 4-year surveillance of carbapenem-resistant Acinetobacter spp. isolates in Argentina identified 40 strains carrying blaNDM-1. Genome sequencing revealed that most were Acinetobacter baumannii, whereas seven represented other Acinetobacter spp. The A. baumannii genomes were closely related, suggesting recent spread. blaNDM-1 was located in the chromosome of A. baumannii strains and on a plasmid in non-A. baumannii strains. A resistance gene island carrying blaPER-7 and other resistance determinants was found on a plasmid in some A. baumannii strains.

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