Paediatric and adult-onset male hypogonadism

The hypothalamic–pituitary–gonadal axis is of relevance in many processes related to the development, maturation and ageing of the male. Through this axis, a cascade of coordinated activities is carried out leading to sustained testicular endocrine function, with gonadal testosterone production, as...

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Autores: Salonia, Andrea, Rastrelli, Giulia, Hackett, Geoffrey, Seminara, Stephanie B., Huhtaniemi, Ilpo T., Rey, Rodolfo Alberto, Hellstrom, Wayne J. G., Palmert, Mark R., Corona, Giovanni, Dohle, Gert R., Khera, Mohit, Chan, Yee-Ming, Maggi, Mario
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2019
País:Argentina
Institución:Consejo Nacional de Investigaciones Científicas y Técnicas
Repositorio:CONICET Digital (CONICET)
Idioma:inglés
OAI Identifier:oai:ri.conicet.gov.ar:11336/139079
Acceso en línea:http://hdl.handle.net/11336/139079
Access Level:acceso abierto
Palabra clave:ANDROGENS
AMH
SERTOLI
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https://purl.org/becyt/ford/3
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spelling Paediatric and adult-onset male hypogonadismSalonia, AndreaRastrelli, GiuliaHackett, GeoffreySeminara, Stephanie B.Huhtaniemi, Ilpo T.Rey, Rodolfo AlbertoHellstrom, Wayne J. G.Palmert, Mark R.Corona, GiovanniDohle, Gert R.Khera, MohitChan, Yee-MingMaggi, MarioANDROGENSAMHSERTOLILEYDIGhttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3The hypothalamic–pituitary–gonadal axis is of relevance in many processes related to the development, maturation and ageing of the male. Through this axis, a cascade of coordinated activities is carried out leading to sustained testicular endocrine function, with gonadal testosterone production, as well as exocrine function, with spermatogenesis. Conditions impairing the hypothalamic–pituitary–gonadal axis during paediatric or pubertal life may result in delayed puberty. Late-onset hypogonadism is a clinical condition in the ageing male combining low concentrations of circulating testosterone and specific symptoms associated with impaired hormone production. Testosterone therapy for congenital forms of hypogonadism must be lifelong, whereas testosterone treatment of late-onset hypogonadism remains a matter of debate because of unclear indications for replacement, uncertain efficacy and potential risks. This Primer focuses on a reappraisal of the physiological role of testosterone, with emphasis on the critical interpretation of the hypogonadal conditions throughout the lifespan of the male individual, with the exception of hypogonadal states resulting from congenital disorders of sex development.Fil: Salonia, Andrea. Università Vita-Salute San Raffael; ItaliaFil: Rastrelli, Giulia. University of Florence; ItaliaFil: Hackett, Geoffrey. University of Bedfordshire; Reino UnidoFil: Seminara, Stephanie B.. Massachusetts General Hospital ; Department Of Medicine ; Harvard Medical School; Estados UnidosFil: Huhtaniemi, Ilpo T.. University College London; Estados UnidosFil: Rey, Rodolfo Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Gobierno de la Ciudad de Buenos Aires. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Fundación de Endocrinología Infantil. Centro de Investigaciones Endocrinológicas "Dr. César Bergada"; ArgentinaFil: Hellstrom, Wayne J. G.. University of Tulane; Estados UnidosFil: Palmert, Mark R.. University of Toronto; CanadáFil: Corona, Giovanni. University of Florence; ItaliaFil: Dohle, Gert R.. Erasmus University Medical Centre; Países BajosFil: Khera, Mohit. Baylor College of Medicine;Fil: Chan, Yee-Ming. Harvard Medical School; Estados UnidosFil: Maggi, Mario. University of Florence; ItaliaNature Publishing Group2019-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/139079Salonia, Andrea; Rastrelli, Giulia; Hackett, Geoffrey; Seminara, Stephanie B.; Huhtaniemi, Ilpo T.; et al.; Paediatric and adult-onset male hypogonadism; Nature Publishing Group; Nature Reviews Disease Primers; 5; 1; 5-2019; 1-212056-676X2056-676XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://www.nature.com/articles/s41572-019-0087-yinfo:eu-repo/semantics/altIdentifier/doi/10.1038/s41572-019-0087-yinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2024-05-08T14:13:56Zoai:ri.conicet.gov.ar:11336/139079instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982024-05-08 14:13:56.783CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Paediatric and adult-onset male hypogonadism
title Paediatric and adult-onset male hypogonadism
spellingShingle Paediatric and adult-onset male hypogonadism
Salonia, Andrea
ANDROGENS
AMH
SERTOLI
LEYDIG
https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
title_short Paediatric and adult-onset male hypogonadism
title_full Paediatric and adult-onset male hypogonadism
title_fullStr Paediatric and adult-onset male hypogonadism
title_full_unstemmed Paediatric and adult-onset male hypogonadism
title_sort Paediatric and adult-onset male hypogonadism
dc.creator.none.fl_str_mv Salonia, Andrea
Rastrelli, Giulia
Hackett, Geoffrey
Seminara, Stephanie B.
Huhtaniemi, Ilpo T.
Rey, Rodolfo Alberto
Hellstrom, Wayne J. G.
Palmert, Mark R.
Corona, Giovanni
Dohle, Gert R.
Khera, Mohit
Chan, Yee-Ming
Maggi, Mario
author Salonia, Andrea
author_facet Salonia, Andrea
Rastrelli, Giulia
Hackett, Geoffrey
Seminara, Stephanie B.
Huhtaniemi, Ilpo T.
Rey, Rodolfo Alberto
Hellstrom, Wayne J. G.
Palmert, Mark R.
Corona, Giovanni
Dohle, Gert R.
Khera, Mohit
Chan, Yee-Ming
Maggi, Mario
author_role author
author2 Rastrelli, Giulia
Hackett, Geoffrey
Seminara, Stephanie B.
Huhtaniemi, Ilpo T.
Rey, Rodolfo Alberto
Hellstrom, Wayne J. G.
Palmert, Mark R.
Corona, Giovanni
Dohle, Gert R.
Khera, Mohit
Chan, Yee-Ming
Maggi, Mario
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv ANDROGENS
AMH
SERTOLI
LEYDIG
https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
topic ANDROGENS
AMH
SERTOLI
LEYDIG
https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
description The hypothalamic–pituitary–gonadal axis is of relevance in many processes related to the development, maturation and ageing of the male. Through this axis, a cascade of coordinated activities is carried out leading to sustained testicular endocrine function, with gonadal testosterone production, as well as exocrine function, with spermatogenesis. Conditions impairing the hypothalamic–pituitary–gonadal axis during paediatric or pubertal life may result in delayed puberty. Late-onset hypogonadism is a clinical condition in the ageing male combining low concentrations of circulating testosterone and specific symptoms associated with impaired hormone production. Testosterone therapy for congenital forms of hypogonadism must be lifelong, whereas testosterone treatment of late-onset hypogonadism remains a matter of debate because of unclear indications for replacement, uncertain efficacy and potential risks. This Primer focuses on a reappraisal of the physiological role of testosterone, with emphasis on the critical interpretation of the hypogonadal conditions throughout the lifespan of the male individual, with the exception of hypogonadal states resulting from congenital disorders of sex development.
publishDate 2019
dc.date.none.fl_str_mv 2019-05
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/139079
Salonia, Andrea; Rastrelli, Giulia; Hackett, Geoffrey; Seminara, Stephanie B.; Huhtaniemi, Ilpo T.; et al.; Paediatric and adult-onset male hypogonadism; Nature Publishing Group; Nature Reviews Disease Primers; 5; 1; 5-2019; 1-21
2056-676X
2056-676X
CONICET Digital
CONICET
url http://hdl.handle.net/11336/139079
identifier_str_mv Salonia, Andrea; Rastrelli, Giulia; Hackett, Geoffrey; Seminara, Stephanie B.; Huhtaniemi, Ilpo T.; et al.; Paediatric and adult-onset male hypogonadism; Nature Publishing Group; Nature Reviews Disease Primers; 5; 1; 5-2019; 1-21
2056-676X
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.nature.com/articles/s41572-019-0087-y
info:eu-repo/semantics/altIdentifier/doi/10.1038/s41572-019-0087-y
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Nature Publishing Group
publisher.none.fl_str_mv Nature Publishing Group
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 15,811543

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