Ureaplasma urealyticum and mycoplasma hominis sensitivity to bacteriocins produced by two lactobacilli strains

The purpose of the present study was to determine the inhibitory activities of two bacteriocins, produced by lactobacilli, against genital mycoplasmas. In this study, infections produced by genital mycoplasmas were studied; of these, 1.3% were caused by Mycoplasma hominis, 10.7% by Ureaplasma urealy...

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Detalhes bibliográficos
Autores: Daniele, M., Ruiz, Francisco Oscar, Pascual, L., Barberis, Isabel Lucila
Tipo de documento: artigo
Estado:Versão publicada
Data de publicação:2011
País:Argentina
Recursos:Consejo Nacional de Investigaciones Científicas y Técnicas
Repositório:CONICET Digital (CONICET)
Idioma:inglês
OAI Identifier:oai:ri.conicet.gov.ar:11336/190849
Acesso em linha:http://hdl.handle.net/11336/190849
Access Level:Acceso aberto
Palavra-chave:M. hominis
Bacteriocin
U. urealyticum
L. fermentum
https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
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repository_id_str
spelling Ureaplasma urealyticum and mycoplasma hominis sensitivity to bacteriocins produced by two lactobacilli strainsDaniele, M.Ruiz, Francisco OscarPascual, L.Barberis, Isabel LucilaM. hominisBacteriocinU. urealyticumL. fermentumhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1The purpose of the present study was to determine the inhibitory activities of two bacteriocins, produced by lactobacilli, against genital mycoplasmas. In this study, infections produced by genital mycoplasmas were studied; of these, 1.3% were caused by Mycoplasma hominis, 10.7% by Ureaplasma urealyticum and 5.6% by U. urealyticum + M. hominis. U. urealyticum was isolated from 75 out of 123 patients with genital mycoplasmas, while M. hominis was isolated from 9 patients (7.3%) and both U. urealyticum and M. hominis from 39 patients (31.7%). Bacteriocins, L23 and L60, produced by Lactobacillus fermentum and L. rhamnosus, respectively, appear to be two novel inhibitors of bacterial infection with potential antibacterial activity. Both bacteriocins proved to be active against 100% of strains tested; MICs of bacteriocin L23 ranged between 320 and 160 UA ml -1 for 78% of the M. hominis strains and between 320 and 80 UA ml -1 for 95% of the U. urealyticum strains. In addition, bacteriocin L60 was still active at 160 UA ml -1 for a high percentage (56%) of M. hominis strains, and at 80 UA ml -1 for 53% of the U. urealyticum strains. Interestingly, these antimicrobial substances produced by lactobacilli showed an inhibitory activity against genital mycoplasmas even when diluted. Altogether, our study indicates that the bacteriocins, L23 and L60, are good candidates for the treatment or prevention of genital infections in women.Fil: Daniele, M.. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas, Fisicoquímicas y Naturales. Departamento de Microbiología e Inmunología; ArgentinaFil: Ruiz, Francisco Oscar. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas, Fisicoquímicas y Naturales. Departamento de Microbiología e Inmunología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; ArgentinaFil: Pascual, L.. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas, Fisicoquímicas y Naturales. Departamento de Microbiología e Inmunología; ArgentinaFil: Barberis, Isabel Lucila. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas, Fisicoquímicas y Naturales. Departamento de Microbiología e Inmunología; ArgentinaSpringer2011-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/190849Daniele, M.; Ruiz, Francisco Oscar; Pascual, L.; Barberis, Isabel Lucila; Ureaplasma urealyticum and mycoplasma hominis sensitivity to bacteriocins produced by two lactobacilli strains; Springer; Current Microbiology; 63; 4; 9-2011; 360-3650343-8651CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007/s00284-011-9989-yinfo:eu-repo/semantics/altIdentifier/doi/10.1007/s00284-011-9989-yinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2024-05-08T14:11:32Zoai:ri.conicet.gov.ar:11336/190849instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982024-05-08 14:11:32.542CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Ureaplasma urealyticum and mycoplasma hominis sensitivity to bacteriocins produced by two lactobacilli strains
title Ureaplasma urealyticum and mycoplasma hominis sensitivity to bacteriocins produced by two lactobacilli strains
spellingShingle Ureaplasma urealyticum and mycoplasma hominis sensitivity to bacteriocins produced by two lactobacilli strains
Daniele, M.
M. hominis
Bacteriocin
U. urealyticum
L. fermentum
https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
title_short Ureaplasma urealyticum and mycoplasma hominis sensitivity to bacteriocins produced by two lactobacilli strains
title_full Ureaplasma urealyticum and mycoplasma hominis sensitivity to bacteriocins produced by two lactobacilli strains
title_fullStr Ureaplasma urealyticum and mycoplasma hominis sensitivity to bacteriocins produced by two lactobacilli strains
title_full_unstemmed Ureaplasma urealyticum and mycoplasma hominis sensitivity to bacteriocins produced by two lactobacilli strains
title_sort Ureaplasma urealyticum and mycoplasma hominis sensitivity to bacteriocins produced by two lactobacilli strains
dc.creator.none.fl_str_mv Daniele, M.
Ruiz, Francisco Oscar
Pascual, L.
Barberis, Isabel Lucila
author Daniele, M.
author_facet Daniele, M.
Ruiz, Francisco Oscar
Pascual, L.
Barberis, Isabel Lucila
author_role author
author2 Ruiz, Francisco Oscar
Pascual, L.
Barberis, Isabel Lucila
author2_role author
author
author
dc.subject.none.fl_str_mv M. hominis
Bacteriocin
U. urealyticum
L. fermentum
https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
topic M. hominis
Bacteriocin
U. urealyticum
L. fermentum
https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
description The purpose of the present study was to determine the inhibitory activities of two bacteriocins, produced by lactobacilli, against genital mycoplasmas. In this study, infections produced by genital mycoplasmas were studied; of these, 1.3% were caused by Mycoplasma hominis, 10.7% by Ureaplasma urealyticum and 5.6% by U. urealyticum + M. hominis. U. urealyticum was isolated from 75 out of 123 patients with genital mycoplasmas, while M. hominis was isolated from 9 patients (7.3%) and both U. urealyticum and M. hominis from 39 patients (31.7%). Bacteriocins, L23 and L60, produced by Lactobacillus fermentum and L. rhamnosus, respectively, appear to be two novel inhibitors of bacterial infection with potential antibacterial activity. Both bacteriocins proved to be active against 100% of strains tested; MICs of bacteriocin L23 ranged between 320 and 160 UA ml -1 for 78% of the M. hominis strains and between 320 and 80 UA ml -1 for 95% of the U. urealyticum strains. In addition, bacteriocin L60 was still active at 160 UA ml -1 for a high percentage (56%) of M. hominis strains, and at 80 UA ml -1 for 53% of the U. urealyticum strains. Interestingly, these antimicrobial substances produced by lactobacilli showed an inhibitory activity against genital mycoplasmas even when diluted. Altogether, our study indicates that the bacteriocins, L23 and L60, are good candidates for the treatment or prevention of genital infections in women.
publishDate 2011
dc.date.none.fl_str_mv 2011-09
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/190849
Daniele, M.; Ruiz, Francisco Oscar; Pascual, L.; Barberis, Isabel Lucila; Ureaplasma urealyticum and mycoplasma hominis sensitivity to bacteriocins produced by two lactobacilli strains; Springer; Current Microbiology; 63; 4; 9-2011; 360-365
0343-8651
CONICET Digital
CONICET
url http://hdl.handle.net/11336/190849
identifier_str_mv Daniele, M.; Ruiz, Francisco Oscar; Pascual, L.; Barberis, Isabel Lucila; Ureaplasma urealyticum and mycoplasma hominis sensitivity to bacteriocins produced by two lactobacilli strains; Springer; Current Microbiology; 63; 4; 9-2011; 360-365
0343-8651
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007/s00284-011-9989-y
info:eu-repo/semantics/altIdentifier/doi/10.1007/s00284-011-9989-y
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Springer
publisher.none.fl_str_mv Springer
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 15,81155

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