Cell-surface translational dynamics of nicotinic acetylcholine receptors

Fil: Barrantes, Francisco José. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas. Laboratorio de Neurobiología Molecular; Argentina

Bibliographic Details
Author: Barrantes, Francisco José
Format: article
Status:Published version
Publication Date:2014
Country:Argentina
Institution:Pontificia Universidad Católica Argentina
Repository:Repositorio Institucional (UCA)
Language:English
OAI Identifier:oai:ucacris:123456789/8750
Online Access:https://repositorio.uca.edu.ar/handle/123456789/8750
Access Level:Open access
Keyword:MEDICINA
COLESTEROL
RECEPTORES
NEUROTRANSMISORES
MEMBRANAS CELULARES
id AR_41a1b5cbf2fe4b2a1bd06114ffcb030c
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spelling Cell-surface translational dynamics of nicotinic acetylcholine receptorsBarrantes, Francisco JoséMEDICINACOLESTEROLRECEPTORESNEUROTRANSMISORESMEMBRANAS CELULARESFil: Barrantes, Francisco José. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas. Laboratorio de Neurobiología Molecular; ArgentinaFil: Barrantes, Francisco José. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaAbstract: Synapse efficacy heavily relies on the number of neurotransmitter receptors available at a given time. In addition to the equilibrium between the biosynthetic production, exocytic delivery and recycling of receptors on the one hand, and the endocytic internalization on the other, lateral diffusion and clustering of receptors at the cell membrane play key roles in determining the amount of active receptors at the synapse. Mobile receptors traffic between reservoir compartments and the synapse by thermally driven Brownian motion, and become immobilized at the peri-synaptic region or the synapse by: (a) clustering mediated by homotropic inter-molecular receptor-receptor associations; (b) heterotropic associations with non-receptor scaffolding proteins or the subjacent cytoskeletal meshwork, leading to diffusional "trapping," and (c) protein-lipid interactions, particularly with the neutral lipid cholesterol. This review assesses the contribution of some of these mechanisms to the supramolecular organization and dynamics of the paradigm neurotransmitter receptor of muscle and neuronal cells -the nicotinic acetylcholine receptor (nAChR). Currently available information stemming from various complementary biophysical techniques commonly used to interrogate the dynamics of cell-surface components is critically discussed. The translational mobility of nAChRs at the cell surface differs between muscle and neuronal receptors in terms of diffusion coefficients and residence intervals at the synapse, which cover an ample range of time regimes. A peculiar feature of brain α7 nAChR is its ability to spend much of its time confined peri-synaptically, vicinal to glutamatergic (excitatory) and GABAergic (inhibitory) synapses. An important function of the α7 nAChR may thus be visiting the territories of other neurotransmitter receptors, differentially regulating the dynamic equilibrium between excitation and inhibition, depending on its residence time in each domain.Frontiers2014info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttps://repositorio.uca.edu.ar/handle/123456789/87501663-3563 (online)10.3389/fnsyn.2014.00025Barrantes FJ (2014). Cell-surface translational dynamics of nicotinic acetyl-choline receptors. Front. Synaptic Neurosci. 6:25. doi:10.3389/fnsyn.2014.00025. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/8750Frontiers in Synaptic Neuroscience Vol. 6, N° 25, 2014reponame:Repositorio Institucional (UCA)instname:Pontificia Universidad Católica Argentinaenginfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/4.0/2024-05-15T12:24:22Zoai:ucacris:123456789/8750instacron:UCAInstitucionalhttps://repositorio.uca.edu.ar/Universidad privadaNo correspondehttps://repositorio.uca.edu.ar/oaiclaudia_fernandez@uca.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:25852024-05-15 12:24:23.191Repositorio Institucional (UCA) - Pontificia Universidad Católica Argentinafalse
dc.title.none.fl_str_mv Cell-surface translational dynamics of nicotinic acetylcholine receptors
title Cell-surface translational dynamics of nicotinic acetylcholine receptors
spellingShingle Cell-surface translational dynamics of nicotinic acetylcholine receptors
Barrantes, Francisco José
MEDICINA
COLESTEROL
RECEPTORES
NEUROTRANSMISORES
MEMBRANAS CELULARES
title_short Cell-surface translational dynamics of nicotinic acetylcholine receptors
title_full Cell-surface translational dynamics of nicotinic acetylcholine receptors
title_fullStr Cell-surface translational dynamics of nicotinic acetylcholine receptors
title_full_unstemmed Cell-surface translational dynamics of nicotinic acetylcholine receptors
title_sort Cell-surface translational dynamics of nicotinic acetylcholine receptors
dc.creator.none.fl_str_mv Barrantes, Francisco José
author Barrantes, Francisco José
author_facet Barrantes, Francisco José
author_role author
dc.subject.none.fl_str_mv MEDICINA
COLESTEROL
RECEPTORES
NEUROTRANSMISORES
MEMBRANAS CELULARES
topic MEDICINA
COLESTEROL
RECEPTORES
NEUROTRANSMISORES
MEMBRANAS CELULARES
description Fil: Barrantes, Francisco José. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas. Laboratorio de Neurobiología Molecular; Argentina
publishDate 2014
dc.date.none.fl_str_mv 2014
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://repositorio.uca.edu.ar/handle/123456789/8750
1663-3563 (online)
10.3389/fnsyn.2014.00025
Barrantes FJ (2014). Cell-surface translational dynamics of nicotinic acetyl-choline receptors. Front. Synaptic Neurosci. 6:25. doi:10.3389/fnsyn.2014.00025. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/8750
url https://repositorio.uca.edu.ar/handle/123456789/8750
identifier_str_mv 1663-3563 (online)
10.3389/fnsyn.2014.00025
Barrantes FJ (2014). Cell-surface translational dynamics of nicotinic acetyl-choline receptors. Front. Synaptic Neurosci. 6:25. doi:10.3389/fnsyn.2014.00025. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/8750
dc.language.none.fl_str_mv eng
language eng
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/4.0/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/4.0/
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Frontiers
publisher.none.fl_str_mv Frontiers
dc.source.none.fl_str_mv Frontiers in Synaptic Neuroscience Vol. 6, N° 25, 2014
reponame:Repositorio Institucional (UCA)
instname:Pontificia Universidad Católica Argentina
instname_str Pontificia Universidad Católica Argentina
reponame_str Repositorio Institucional (UCA)
collection Repositorio Institucional (UCA)
repository.name.fl_str_mv Repositorio Institucional (UCA) - Pontificia Universidad Católica Argentina
repository.mail.fl_str_mv claudia_fernandez@uca.edu.ar
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score 15.812429

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