Forced Desynchronization of Activity Rhythms in a Model of Chronic Jet Lag in Mice

We studied locomotor activity rhythms of C57/Bl6 mice under a chronic jet lag (CJL) protocol (ChrA6/2), which consisted of 6-hour phase advances of the light-dark schedule (LD) every 2 days. Through periodogram analysis, we found 2 components of the activity rhythm: a short-period component (21.01 ±...

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Detalles Bibliográficos
Autores: Casiraghi, Leandro Pablo, Oda, Gisele A., Chiesa, Juan José, Friesen, W. Otto, Golombek, Diego Andres
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2012
País:Argentina
Institución:Consejo Nacional de Investigaciones Científicas y Técnicas
Repositorio:CONICET Digital (CONICET)
Idioma:inglés
OAI Identifier:oai:ri.conicet.gov.ar:11336/194851
Acceso en línea:http://hdl.handle.net/11336/194851
Access Level:acceso abierto
Palabra clave:CHRONIC JET LAG
CIRCADIAN DISRUPTION
ENTRAINMENT
LOCOMOTOR ACTIVITY RHYTHMS
MATHEMATICAL SIMULATIONS
OSCILLATOR MODEL
SHIFT WORK
https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
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oai_identifier_str oai:ri.conicet.gov.ar:11336/194851
network_acronym_str AR
network_name_str Argentina
repository_id_str
dc.title.none.fl_str_mv Forced Desynchronization of Activity Rhythms in a Model of Chronic Jet Lag in Mice
title Forced Desynchronization of Activity Rhythms in a Model of Chronic Jet Lag in Mice
spellingShingle Forced Desynchronization of Activity Rhythms in a Model of Chronic Jet Lag in Mice
Casiraghi, Leandro Pablo
CHRONIC JET LAG
CIRCADIAN DISRUPTION
ENTRAINMENT
LOCOMOTOR ACTIVITY RHYTHMS
MATHEMATICAL SIMULATIONS
OSCILLATOR MODEL
SHIFT WORK
https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
title_short Forced Desynchronization of Activity Rhythms in a Model of Chronic Jet Lag in Mice
title_full Forced Desynchronization of Activity Rhythms in a Model of Chronic Jet Lag in Mice
title_fullStr Forced Desynchronization of Activity Rhythms in a Model of Chronic Jet Lag in Mice
title_full_unstemmed Forced Desynchronization of Activity Rhythms in a Model of Chronic Jet Lag in Mice
title_sort Forced Desynchronization of Activity Rhythms in a Model of Chronic Jet Lag in Mice
dc.creator.none.fl_str_mv Casiraghi, Leandro Pablo
Oda, Gisele A.
Chiesa, Juan José
Friesen, W. Otto
Golombek, Diego Andres
author Casiraghi, Leandro Pablo
author_facet Casiraghi, Leandro Pablo
Oda, Gisele A.
Chiesa, Juan José
Friesen, W. Otto
Golombek, Diego Andres
author_role author
author2 Oda, Gisele A.
Chiesa, Juan José
Friesen, W. Otto
Golombek, Diego Andres
author2_role author
author
author
author
dc.subject.none.fl_str_mv CHRONIC JET LAG
CIRCADIAN DISRUPTION
ENTRAINMENT
LOCOMOTOR ACTIVITY RHYTHMS
MATHEMATICAL SIMULATIONS
OSCILLATOR MODEL
SHIFT WORK
https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
topic CHRONIC JET LAG
CIRCADIAN DISRUPTION
ENTRAINMENT
LOCOMOTOR ACTIVITY RHYTHMS
MATHEMATICAL SIMULATIONS
OSCILLATOR MODEL
SHIFT WORK
https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
description We studied locomotor activity rhythms of C57/Bl6 mice under a chronic jet lag (CJL) protocol (ChrA6/2), which consisted of 6-hour phase advances of the light-dark schedule (LD) every 2 days. Through periodogram analysis, we found 2 components of the activity rhythm: a short-period component (21.01 ± 0.04 h) that was entrained by the LD schedule and a long-period component (24.68 ± 0.26 h). We developed a mathematical model comprising 2 coupled circadian oscillators that was tested experimentally with different CJL schedules. Our simulations suggested that under CJL, the system behaves as if it were under a zeitgeber with a period determined by (24-[phase shift size/days between shifts]). Desynchronization within the system arises according to whether this effective zeitgeber is inside or outside the range of entrainment of the oscillators. In this sense, ChrA6/2 is interpreted as a (24 - 6/2 = 21 h) zeitgeber, and simulations predicted the behavior of mice under other CJL schedules with an effective 21-hour zeitgeber. Animals studied under an asymmetric T = 21 h zeitgeber (carried out by a 3-hour shortening of every dark phase) showed 2 activity components as observed under ChrA6/2: an entrained short-period (21.01 ± 0.03 h) and a long-period component (23.93 ± 0.31 h). Internal desynchronization was lost when mice were subjected to 9-hour advances every 3 days, a possibility also contemplated by the simulations. Simulations also predicted that desynchronization should be less prevalent under delaying than under advancing CJL. Indeed, most mice subjected to 6-hour delay shifts every 2 days (an effective 27-hour zeitgeber) displayed a single entrained activity component (26.92 ± 0.11 h). Our results demonstrate that the disruption provoked by CJL schedules is not dependent on the phase-shift magnitude or the frequency of the shifts separately but on the combination of both, through its ratio and additionally on their absolute values. In this study, we present a novel model of forced desynchronization in mice under a specific CJL schedule; in addition, our model provides theoretical tools for the evaluation of circadian disruption under CJL conditions that are currently used in circadian research.
publishDate 2012
dc.date.none.fl_str_mv 2012-02
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/194851
Casiraghi, Leandro Pablo; Oda, Gisele A.; Chiesa, Juan José; Friesen, W. Otto; Golombek, Diego Andres; Forced Desynchronization of Activity Rhythms in a Model of Chronic Jet Lag in Mice; SAGE Publications; Journal of Biological Rhythms; 27; 1; 2-2012; 59-69
0748-7304
CONICET Digital
CONICET
url http://hdl.handle.net/11336/194851
identifier_str_mv Casiraghi, Leandro Pablo; Oda, Gisele A.; Chiesa, Juan José; Friesen, W. Otto; Golombek, Diego Andres; Forced Desynchronization of Activity Rhythms in a Model of Chronic Jet Lag in Mice; SAGE Publications; Journal of Biological Rhythms; 27; 1; 2-2012; 59-69
0748-7304
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://journals.sagepub.com/doi/10.1177/0748730411429447
info:eu-repo/semantics/altIdentifier/doi/10.1177/0748730411429447
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv SAGE Publications
publisher.none.fl_str_mv SAGE Publications
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1799196298116595712
spelling Forced Desynchronization of Activity Rhythms in a Model of Chronic Jet Lag in MiceCasiraghi, Leandro PabloOda, Gisele A.Chiesa, Juan JoséFriesen, W. OttoGolombek, Diego AndresCHRONIC JET LAGCIRCADIAN DISRUPTIONENTRAINMENTLOCOMOTOR ACTIVITY RHYTHMSMATHEMATICAL SIMULATIONSOSCILLATOR MODELSHIFT WORKhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1We studied locomotor activity rhythms of C57/Bl6 mice under a chronic jet lag (CJL) protocol (ChrA6/2), which consisted of 6-hour phase advances of the light-dark schedule (LD) every 2 days. Through periodogram analysis, we found 2 components of the activity rhythm: a short-period component (21.01 ± 0.04 h) that was entrained by the LD schedule and a long-period component (24.68 ± 0.26 h). We developed a mathematical model comprising 2 coupled circadian oscillators that was tested experimentally with different CJL schedules. Our simulations suggested that under CJL, the system behaves as if it were under a zeitgeber with a period determined by (24-[phase shift size/days between shifts]). Desynchronization within the system arises according to whether this effective zeitgeber is inside or outside the range of entrainment of the oscillators. In this sense, ChrA6/2 is interpreted as a (24 - 6/2 = 21 h) zeitgeber, and simulations predicted the behavior of mice under other CJL schedules with an effective 21-hour zeitgeber. Animals studied under an asymmetric T = 21 h zeitgeber (carried out by a 3-hour shortening of every dark phase) showed 2 activity components as observed under ChrA6/2: an entrained short-period (21.01 ± 0.03 h) and a long-period component (23.93 ± 0.31 h). Internal desynchronization was lost when mice were subjected to 9-hour advances every 3 days, a possibility also contemplated by the simulations. Simulations also predicted that desynchronization should be less prevalent under delaying than under advancing CJL. Indeed, most mice subjected to 6-hour delay shifts every 2 days (an effective 27-hour zeitgeber) displayed a single entrained activity component (26.92 ± 0.11 h). Our results demonstrate that the disruption provoked by CJL schedules is not dependent on the phase-shift magnitude or the frequency of the shifts separately but on the combination of both, through its ratio and additionally on their absolute values. In this study, we present a novel model of forced desynchronization in mice under a specific CJL schedule; in addition, our model provides theoretical tools for the evaluation of circadian disruption under CJL conditions that are currently used in circadian research.Fil: Casiraghi, Leandro Pablo. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Cronobiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Oda, Gisele A.. Universidade de Sao Paulo; BrasilFil: Chiesa, Juan José. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Cronobiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Friesen, W. Otto. University of Virginia; Estados UnidosFil: Golombek, Diego Andres. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Cronobiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaSAGE Publications2012-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/194851Casiraghi, Leandro Pablo; Oda, Gisele A.; Chiesa, Juan José; Friesen, W. Otto; Golombek, Diego Andres; Forced Desynchronization of Activity Rhythms in a Model of Chronic Jet Lag in Mice; SAGE Publications; Journal of Biological Rhythms; 27; 1; 2-2012; 59-690748-7304CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://journals.sagepub.com/doi/10.1177/0748730411429447info:eu-repo/semantics/altIdentifier/doi/10.1177/0748730411429447info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2024-05-08T14:22:08Zoai:ri.conicet.gov.ar:11336/194851instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982024-05-08 14:22:08.977CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
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