Inter-individual variability for high fat diet consumption in inbred C57BL/6 mice

Since inbred C57BL/6 mice are known to show inter-individual phenotypic variability for some traits, we tested the hypothesis that inbred C57BL/6 mice display a different tendency to consume a high fat (HF) diet. For this purpose, we used a compilation of HF intake data from an experimental protocol...

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Detalles Bibliográficos
Autores: de Francesco, Pablo Nicolás, Cornejo, María Paula, Barrile, Franco, García Romero, Guadalupe, Valdivia, Spring, Andreoli, María F., Perello, Mario
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2019
País:Argentina
Institución:Consejo Nacional de Investigaciones Científicas y Técnicas
Repositorio:CONICET Digital (CONICET)
Idioma:inglés
OAI Identifier:oai:ri.conicet.gov.ar:11336/127845
Acceso en línea:http://hdl.handle.net/11336/127845
Access Level:acceso abierto
Palabra clave:EATING BEHAVIORS
FOOD INTAKE
INTER-INDIVIDUALITY
OBESITY
PALATABLE FOODS
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
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oai_identifier_str oai:ri.conicet.gov.ar:11336/127845
network_acronym_str AR
network_name_str Argentina
repository_id_str
dc.title.none.fl_str_mv Inter-individual variability for high fat diet consumption in inbred C57BL/6 mice
title Inter-individual variability for high fat diet consumption in inbred C57BL/6 mice
spellingShingle Inter-individual variability for high fat diet consumption in inbred C57BL/6 mice
de Francesco, Pablo Nicolás
EATING BEHAVIORS
FOOD INTAKE
INTER-INDIVIDUALITY
OBESITY
PALATABLE FOODS
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
title_short Inter-individual variability for high fat diet consumption in inbred C57BL/6 mice
title_full Inter-individual variability for high fat diet consumption in inbred C57BL/6 mice
title_fullStr Inter-individual variability for high fat diet consumption in inbred C57BL/6 mice
title_full_unstemmed Inter-individual variability for high fat diet consumption in inbred C57BL/6 mice
title_sort Inter-individual variability for high fat diet consumption in inbred C57BL/6 mice
dc.creator.none.fl_str_mv de Francesco, Pablo Nicolás
Cornejo, María Paula
Barrile, Franco
García Romero, Guadalupe
Valdivia, Spring
Andreoli, María F.
Perello, Mario
author de Francesco, Pablo Nicolás
author_facet de Francesco, Pablo Nicolás
Cornejo, María Paula
Barrile, Franco
García Romero, Guadalupe
Valdivia, Spring
Andreoli, María F.
Perello, Mario
author_role author
author2 Cornejo, María Paula
Barrile, Franco
García Romero, Guadalupe
Valdivia, Spring
Andreoli, María F.
Perello, Mario
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv EATING BEHAVIORS
FOOD INTAKE
INTER-INDIVIDUALITY
OBESITY
PALATABLE FOODS
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
topic EATING BEHAVIORS
FOOD INTAKE
INTER-INDIVIDUALITY
OBESITY
PALATABLE FOODS
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
description Since inbred C57BL/6 mice are known to show inter-individual phenotypic variability for some traits, we tested the hypothesis that inbred C57BL/6 mice display a different tendency to consume a high fat (HF) diet. For this purpose, we used a compilation of HF intake data from an experimental protocol in which satiated mice were exposed to a HF pellet every morning for 2-h over 4 consecutive days. We found that mice displayed a large degree of variability in HF intake. Since day 1 HF intake significantly correlated with HF intake in successive days, we applied a hierarchical clustering algorithm on HF intake measurements in days 2, 3, and 4 in order to classify mice into ?low? or ?high? HF intake groups. ?Low? HF intake group showed a day 1 HF intake similar to that seen in mice exposed to regular chow, while ?high? HF intake group showed a higher day 1 HF intake as compared to ?low? HF intake group. Both groups of mice increased HF consumption over the successive days, but ?high? HF intake group always displayed a higher HF consumption than the ?low? HF intake group. As compared to ?low? HF intake group, ?high? HF intake group showed a higher number of dopamine neurons positive for c-Fos in the VTA after the last event of HF intake. Thus, inbred C57BL/6 mice show inter-individual variability for HF intake and such feature may be linked to a different response to the rewarding properties of the HF diet.
publishDate 2019
dc.date.none.fl_str_mv 2019-05
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/127845
de Francesco, Pablo Nicolás; Cornejo, María Paula; Barrile, Franco; García Romero, Guadalupe; Valdivia, Spring; et al.; Inter-individual variability for high fat diet consumption in inbred C57BL/6 mice; Frontiers Media S.A.; Frontiers in Nutrition; 6; 5-2019; 1-9
2296-861X
CONICET Digital
CONICET
url http://hdl.handle.net/11336/127845
identifier_str_mv de Francesco, Pablo Nicolás; Cornejo, María Paula; Barrile, Franco; García Romero, Guadalupe; Valdivia, Spring; et al.; Inter-individual variability for high fat diet consumption in inbred C57BL/6 mice; Frontiers Media S.A.; Frontiers in Nutrition; 6; 5-2019; 1-9
2296-861X
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6520645/pdf/fnut-06-00067.pdf
info:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/articles/10.3389/fnut.2019.00067
info:eu-repo/semantics/altIdentifier/doi/10.3389/fnut.2019.00067
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Frontiers Media S.A.
publisher.none.fl_str_mv Frontiers Media S.A.
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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spelling Inter-individual variability for high fat diet consumption in inbred C57BL/6 micede Francesco, Pablo NicolásCornejo, María PaulaBarrile, FrancoGarcía Romero, GuadalupeValdivia, SpringAndreoli, María F.Perello, MarioEATING BEHAVIORSFOOD INTAKEINTER-INDIVIDUALITYOBESITYPALATABLE FOODShttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Since inbred C57BL/6 mice are known to show inter-individual phenotypic variability for some traits, we tested the hypothesis that inbred C57BL/6 mice display a different tendency to consume a high fat (HF) diet. For this purpose, we used a compilation of HF intake data from an experimental protocol in which satiated mice were exposed to a HF pellet every morning for 2-h over 4 consecutive days. We found that mice displayed a large degree of variability in HF intake. Since day 1 HF intake significantly correlated with HF intake in successive days, we applied a hierarchical clustering algorithm on HF intake measurements in days 2, 3, and 4 in order to classify mice into ?low? or ?high? HF intake groups. ?Low? HF intake group showed a day 1 HF intake similar to that seen in mice exposed to regular chow, while ?high? HF intake group showed a higher day 1 HF intake as compared to ?low? HF intake group. Both groups of mice increased HF consumption over the successive days, but ?high? HF intake group always displayed a higher HF consumption than the ?low? HF intake group. As compared to ?low? HF intake group, ?high? HF intake group showed a higher number of dopamine neurons positive for c-Fos in the VTA after the last event of HF intake. Thus, inbred C57BL/6 mice show inter-individual variability for HF intake and such feature may be linked to a different response to the rewarding properties of the HF diet.Fil: de Francesco, Pablo Nicolás. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Multidisciplinario de Biología Celular. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Multidisciplinario de Biología Celular. Universidad Nacional de La Plata. Instituto Multidisciplinario de Biología Celular; ArgentinaFil: Cornejo, María Paula. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Multidisciplinario de Biología Celular. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Multidisciplinario de Biología Celular. Universidad Nacional de La Plata. Instituto Multidisciplinario de Biología Celular; ArgentinaFil: Barrile, Franco. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Multidisciplinario de Biología Celular. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Multidisciplinario de Biología Celular. Universidad Nacional de La Plata. Instituto Multidisciplinario de Biología Celular; ArgentinaFil: García Romero, Guadalupe. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Multidisciplinario de Biología Celular. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Multidisciplinario de Biología Celular. Universidad Nacional de La Plata. Instituto Multidisciplinario de Biología Celular; ArgentinaFil: Valdivia, Spring. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Multidisciplinario de Biología Celular. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Multidisciplinario de Biología Celular. Universidad Nacional de La Plata. Instituto Multidisciplinario de Biología Celular; ArgentinaFil: Andreoli, María F.. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas; ArgentinaFil: Perello, Mario. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Multidisciplinario de Biología Celular. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Multidisciplinario de Biología Celular. Universidad Nacional de La Plata. Instituto Multidisciplinario de Biología Celular; ArgentinaFrontiers Media S.A.2019-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/127845de Francesco, Pablo Nicolás; Cornejo, María Paula; Barrile, Franco; García Romero, Guadalupe; Valdivia, Spring; et al.; Inter-individual variability for high fat diet consumption in inbred C57BL/6 mice; Frontiers Media S.A.; Frontiers in Nutrition; 6; 5-2019; 1-92296-861XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6520645/pdf/fnut-06-00067.pdfinfo:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/articles/10.3389/fnut.2019.00067info:eu-repo/semantics/altIdentifier/doi/10.3389/fnut.2019.00067info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2024-05-08T14:18:46Zoai:ri.conicet.gov.ar:11336/127845instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982024-05-08 14:18:46.367CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
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