Characterization of the main placental cytokine profiles from HIV-1-infected pregnant women treated with anti-retroviral drugs in France

Cytokines are involved in regulating HIV-1 infection. They are also placental environment major components.We assessed the potential impact of HIV-1 infection and/or anti-retroviral drugs on the placental cytokine profiles that may be involved in controlling HIV-1 placental dissemination. Placental...

ver descrição completa

Detalhes bibliográficos
Autores: Faye, Albert, Pornprasert, Sakorn, Mary, Jean Yves, Dolcini, Guillermina Laura, Derrien, Muriel, Barré Sinoussi, Françoise, Chaouat, Gérard, Menu, Elisabeth, ANRS study team
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2007
País:Argentina
Recursos:Consejo Nacional de Investigaciones Científicas y Técnicas
Repositorio:CONICET Digital (CONICET)
Idioma:inglés
OAI Identifier:oai:ri.conicet.gov.ar:11336/104753
Acesso em linha:http://hdl.handle.net/11336/104753
Access Level:acceso abierto
Palavra-chave:https://purl.org/becyt/ford/4.3
https://purl.org/becyt/ford/4
https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
id AR_3da889441dda7db855aeb7fd459b392e
oai_identifier_str oai:ri.conicet.gov.ar:11336/104753
network_acronym_str AR
network_name_str Argentina
repository_id_str
dc.title.none.fl_str_mv Characterization of the main placental cytokine profiles from HIV-1-infected pregnant women treated with anti-retroviral drugs in France
title Characterization of the main placental cytokine profiles from HIV-1-infected pregnant women treated with anti-retroviral drugs in France
spellingShingle Characterization of the main placental cytokine profiles from HIV-1-infected pregnant women treated with anti-retroviral drugs in France
Faye, Albert
https://purl.org/becyt/ford/4.3
https://purl.org/becyt/ford/4
https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
title_short Characterization of the main placental cytokine profiles from HIV-1-infected pregnant women treated with anti-retroviral drugs in France
title_full Characterization of the main placental cytokine profiles from HIV-1-infected pregnant women treated with anti-retroviral drugs in France
title_fullStr Characterization of the main placental cytokine profiles from HIV-1-infected pregnant women treated with anti-retroviral drugs in France
title_full_unstemmed Characterization of the main placental cytokine profiles from HIV-1-infected pregnant women treated with anti-retroviral drugs in France
title_sort Characterization of the main placental cytokine profiles from HIV-1-infected pregnant women treated with anti-retroviral drugs in France
dc.creator.none.fl_str_mv Faye, Albert
Pornprasert, Sakorn
Mary, Jean Yves
Dolcini, Guillermina Laura
Derrien, Muriel
Barré Sinoussi, Françoise
Chaouat, Gérard
Menu, Elisabeth
ANRS study team
author Faye, Albert
author_facet Faye, Albert
Pornprasert, Sakorn
Mary, Jean Yves
Dolcini, Guillermina Laura
Derrien, Muriel
Barré Sinoussi, Françoise
Chaouat, Gérard
Menu, Elisabeth
ANRS study team
author_role author
author2 Pornprasert, Sakorn
Mary, Jean Yves
Dolcini, Guillermina Laura
Derrien, Muriel
Barré Sinoussi, Françoise
Chaouat, Gérard
Menu, Elisabeth
ANRS study team
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv https://purl.org/becyt/ford/4.3
https://purl.org/becyt/ford/4
https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
topic https://purl.org/becyt/ford/4.3
https://purl.org/becyt/ford/4
https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
description Cytokines are involved in regulating HIV-1 infection. They are also placental environment major components.We assessed the potential impact of HIV-1 infection and/or anti-retroviral drugs on the placental cytokine profiles that may be involved in controlling HIV-1 placental dissemination. Placental explants were obtained after elective caesarean section from anti-retroviral treated HIV-1-infected pregnant women and from HIV-1 non-infected pregnant women. The main placental cytokines were assessed for protein secretion in the supernatants of 24-h placental culture explants and/or in uncultured placental explants for mRNA expression levels. The cytokine profiles were different between the HIV-1-infected and the non-infected groups. Higher medians of leukaemia inhibiting factor (LIF), tumour necrosis factor (TNF)-a and interleukin (IL)-8 secretion were found in the 24-h culture supernatant of term placenta from HIV-1-infected women. High median levels of IL-16 and regulated upon activation normal T cell expressed and secreted (RANTES) levels were found in both groups. The mRNA expression medians were lower for TNF-a and IL-8 and higher for stromal cell-derived factor-1 (SDF-1) in uncultured placental explants from HIV-1-infected women. In the HIV-1-infected group, but not in the non-infected group, the secretion levels of TNF-a and IL-8, as well as their mRNA expression levels, were highly positively correlated; furthermore, their secretion levels were correlated positively with LIF and IL-10 secretion levels.We found no correlation between the cytokine levels and the immunovirological status of the HIV-1-infected mothers or the type or duration of treatment. These results highlight the potential impact of HIV-1 and of the anti-retroviral treatments on the placental cytokines pattern, independently of their anti-viral activity.
publishDate 2007
dc.date.none.fl_str_mv 2007-05
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/104753
Faye, Albert; Pornprasert, Sakorn; Mary, Jean Yves; Dolcini, Guillermina Laura; Derrien, Muriel; et al.; Characterization of the main placental cytokine profiles from HIV-1-infected pregnant women treated with anti-retroviral drugs in France; Wiley Blackwell Publishing, Inc; Clinical and Experimental Immunology; 149; 3; 5-2007; 430-439
0009-9104
1365-2249
CONICET Digital
CONICET
url http://hdl.handle.net/11336/104753
identifier_str_mv Faye, Albert; Pornprasert, Sakorn; Mary, Jean Yves; Dolcini, Guillermina Laura; Derrien, Muriel; et al.; Characterization of the main placental cytokine profiles from HIV-1-infected pregnant women treated with anti-retroviral drugs in France; Wiley Blackwell Publishing, Inc; Clinical and Experimental Immunology; 149; 3; 5-2007; 430-439
0009-9104
1365-2249
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1111/j.1365-2249.2007.03411.x
info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/full/10.1111/j.1365-2249.2007.03411.x
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley Blackwell Publishing, Inc
publisher.none.fl_str_mv Wiley Blackwell Publishing, Inc
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1799195744892092416
spelling Characterization of the main placental cytokine profiles from HIV-1-infected pregnant women treated with anti-retroviral drugs in FranceFaye, AlbertPornprasert, SakornMary, Jean YvesDolcini, Guillermina LauraDerrien, MurielBarré Sinoussi, FrançoiseChaouat, GérardMenu, ElisabethANRS study teamhttps://purl.org/becyt/ford/4.3https://purl.org/becyt/ford/4https://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Cytokines are involved in regulating HIV-1 infection. They are also placental environment major components.We assessed the potential impact of HIV-1 infection and/or anti-retroviral drugs on the placental cytokine profiles that may be involved in controlling HIV-1 placental dissemination. Placental explants were obtained after elective caesarean section from anti-retroviral treated HIV-1-infected pregnant women and from HIV-1 non-infected pregnant women. The main placental cytokines were assessed for protein secretion in the supernatants of 24-h placental culture explants and/or in uncultured placental explants for mRNA expression levels. The cytokine profiles were different between the HIV-1-infected and the non-infected groups. Higher medians of leukaemia inhibiting factor (LIF), tumour necrosis factor (TNF)-a and interleukin (IL)-8 secretion were found in the 24-h culture supernatant of term placenta from HIV-1-infected women. High median levels of IL-16 and regulated upon activation normal T cell expressed and secreted (RANTES) levels were found in both groups. The mRNA expression medians were lower for TNF-a and IL-8 and higher for stromal cell-derived factor-1 (SDF-1) in uncultured placental explants from HIV-1-infected women. In the HIV-1-infected group, but not in the non-infected group, the secretion levels of TNF-a and IL-8, as well as their mRNA expression levels, were highly positively correlated; furthermore, their secretion levels were correlated positively with LIF and IL-10 secretion levels.We found no correlation between the cytokine levels and the immunovirological status of the HIV-1-infected mothers or the type or duration of treatment. These results highlight the potential impact of HIV-1 and of the anti-retroviral treatments on the placental cytokines pattern, independently of their anti-viral activity.Fil: Faye, Albert. Instituto Pasteur; Francia. Institut National de la Santé et de la Recherche Médicale; FranciaFil: Pornprasert, Sakorn. Chiang Mai University. Faculty of Associated Medical Sciences; Tailandia. Instituto Pasteur; FranciaFil: Mary, Jean Yves. Institut National de la Santé et de la Recherche Médicale; FranciaFil: Dolcini, Guillermina Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina. Universidad de Buenos Aires. Facultad de Medicina; Argentina. Instituto Pasteur; FranciaFil: Derrien, Muriel. Instituto Pasteur; FranciaFil: Barré Sinoussi, Françoise. Instituto Pasteur; FranciaFil: Chaouat, Gérard. Institut National de la Santé et de la Recherche Médicale; FranciaFil: Menu, Elisabeth. Instituto Pasteur; FranciaFil: ANRS study team. No especifíca;Wiley Blackwell Publishing, Inc2007-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/104753Faye, Albert; Pornprasert, Sakorn; Mary, Jean Yves; Dolcini, Guillermina Laura; Derrien, Muriel; et al.; Characterization of the main placental cytokine profiles from HIV-1-infected pregnant women treated with anti-retroviral drugs in France; Wiley Blackwell Publishing, Inc; Clinical and Experimental Immunology; 149; 3; 5-2007; 430-4390009-91041365-2249CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1111/j.1365-2249.2007.03411.xinfo:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/full/10.1111/j.1365-2249.2007.03411.xinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2024-05-08T14:02:12Zoai:ri.conicet.gov.ar:11336/104753instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982024-05-08 14:02:12.673CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
score 15,812455

Registos relacionados