Effect of selective ET A receptor blockade on natriuretic peptide gene expression in DOCA-salt hypertension

To determine the role of endothelin-1 (ET-1) in the upregulation of atrial natriuretic factor (ANF) and brain natriuretic peptide (BNP) observed in deoxycorticosterone acetate (DOCA)-salt hypertension, the selective ET-1 type-A receptor (ETA) antagonist ABT-627 was chronically administered to normal...

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Detalles Bibliográficos
Autores: Bianciotti, Liliana Graciela, de Bold, Adolfo
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2000
País:Argentina
Institución:Consejo Nacional de Investigaciones Científicas y Técnicas
Repositorio:CONICET Digital (CONICET)
Idioma:inglés
OAI Identifier:oai:ri.conicet.gov.ar:11336/40464
Acceso en línea:http://hdl.handle.net/11336/40464
Access Level:acceso abierto
Palabra clave:Doca-Salt Hypertension
Natriuretic Peptide
Eta Endothelin Receptor
https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
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spelling Effect of selective ET A receptor blockade on natriuretic peptide gene expression in DOCA-salt hypertensionBianciotti, Liliana Gracielade Bold, AdolfoDoca-Salt HypertensionNatriuretic PeptideEta Endothelin Receptorhttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3To determine the role of endothelin-1 (ET-1) in the upregulation of atrial natriuretic factor (ANF) and brain natriuretic peptide (BNP) observed in deoxycorticosterone acetate (DOCA)-salt hypertension, the selective ET-1 type-A receptor (ETA) antagonist ABT-627 was chronically administered to normal controls and hypertensive rats. Chronic ETA blockade in DOCA-salt-treated rats prevented the increase in blood pressure and circulating natriuretic protein (NP) levels and partially prevented left ventricular hypertrophy. The changes observed in NP gene expression in the atria were not affected by ABT-627. In the ventricles, ABT-627 reduced NP gene expression. Rats receiving the ETA antagonist alone showed reduced left ventricular NP gene expression. ABT-627 did not affect ventricular collagen III gene expression but enhanced left ventricular α-myosin heavy chain expression. These findings suggest that in vivo, ventricular but not atrial NP production is regulated by ET-1. This difference in response between atrial and ventricular NP gene expression to ETA receptor blockade is similar to that observed by us after applying angiotensin-converting enzyme inhibitors in other hypertensive models. In general therefore, atrial NP gene expression may not be as sensitive to the endocrine environment as is ventricular NP gene expression.Fil: Bianciotti, Liliana Graciela. University of Ottawa; Canadá. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; ArgentinaFil: de Bold, Adolfo. University of Ottawa; Canadá. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; ArgentinaAmerican Physiological Society2000-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/40464Bianciotti, Liliana Graciela; de Bold, Adolfo; Effect of selective ET A receptor blockade on natriuretic peptide gene expression in DOCA-salt hypertension; American Physiological Society; American Journal of Physiology - Heart and Circulatory Physiology; 279; 1; 7-2000; H93-H1010363-6135CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.physiology.org/doi/abs/10.1152/ajpheart.2000.279.1.H93info:eu-repo/semantics/altIdentifier/doi/10.1152/ajpheart.2000.279.1.H93info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2024-05-08T14:20:12Zoai:ri.conicet.gov.ar:11336/40464instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982024-05-08 14:20:12.426CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Effect of selective ET A receptor blockade on natriuretic peptide gene expression in DOCA-salt hypertension
title Effect of selective ET A receptor blockade on natriuretic peptide gene expression in DOCA-salt hypertension
spellingShingle Effect of selective ET A receptor blockade on natriuretic peptide gene expression in DOCA-salt hypertension
Bianciotti, Liliana Graciela
Doca-Salt Hypertension
Natriuretic Peptide
Eta Endothelin Receptor
https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
title_short Effect of selective ET A receptor blockade on natriuretic peptide gene expression in DOCA-salt hypertension
title_full Effect of selective ET A receptor blockade on natriuretic peptide gene expression in DOCA-salt hypertension
title_fullStr Effect of selective ET A receptor blockade on natriuretic peptide gene expression in DOCA-salt hypertension
title_full_unstemmed Effect of selective ET A receptor blockade on natriuretic peptide gene expression in DOCA-salt hypertension
title_sort Effect of selective ET A receptor blockade on natriuretic peptide gene expression in DOCA-salt hypertension
dc.creator.none.fl_str_mv Bianciotti, Liliana Graciela
de Bold, Adolfo
author Bianciotti, Liliana Graciela
author_facet Bianciotti, Liliana Graciela
de Bold, Adolfo
author_role author
author2 de Bold, Adolfo
author2_role author
dc.subject.none.fl_str_mv Doca-Salt Hypertension
Natriuretic Peptide
Eta Endothelin Receptor
https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
topic Doca-Salt Hypertension
Natriuretic Peptide
Eta Endothelin Receptor
https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
description To determine the role of endothelin-1 (ET-1) in the upregulation of atrial natriuretic factor (ANF) and brain natriuretic peptide (BNP) observed in deoxycorticosterone acetate (DOCA)-salt hypertension, the selective ET-1 type-A receptor (ETA) antagonist ABT-627 was chronically administered to normal controls and hypertensive rats. Chronic ETA blockade in DOCA-salt-treated rats prevented the increase in blood pressure and circulating natriuretic protein (NP) levels and partially prevented left ventricular hypertrophy. The changes observed in NP gene expression in the atria were not affected by ABT-627. In the ventricles, ABT-627 reduced NP gene expression. Rats receiving the ETA antagonist alone showed reduced left ventricular NP gene expression. ABT-627 did not affect ventricular collagen III gene expression but enhanced left ventricular α-myosin heavy chain expression. These findings suggest that in vivo, ventricular but not atrial NP production is regulated by ET-1. This difference in response between atrial and ventricular NP gene expression to ETA receptor blockade is similar to that observed by us after applying angiotensin-converting enzyme inhibitors in other hypertensive models. In general therefore, atrial NP gene expression may not be as sensitive to the endocrine environment as is ventricular NP gene expression.
publishDate 2000
dc.date.none.fl_str_mv 2000-07
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/40464
Bianciotti, Liliana Graciela; de Bold, Adolfo; Effect of selective ET A receptor blockade on natriuretic peptide gene expression in DOCA-salt hypertension; American Physiological Society; American Journal of Physiology - Heart and Circulatory Physiology; 279; 1; 7-2000; H93-H101
0363-6135
CONICET Digital
CONICET
url http://hdl.handle.net/11336/40464
identifier_str_mv Bianciotti, Liliana Graciela; de Bold, Adolfo; Effect of selective ET A receptor blockade on natriuretic peptide gene expression in DOCA-salt hypertension; American Physiological Society; American Journal of Physiology - Heart and Circulatory Physiology; 279; 1; 7-2000; H93-H101
0363-6135
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.physiology.org/doi/abs/10.1152/ajpheart.2000.279.1.H93
info:eu-repo/semantics/altIdentifier/doi/10.1152/ajpheart.2000.279.1.H93
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv American Physiological Society
publisher.none.fl_str_mv American Physiological Society
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 15.812429

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