Geographic patterns of genome admixture in latin American mestizos

The large and diverse population of Latin America is potentially a powerful resource for elucidating the genetic basis of complex traits through admixture mapping. However, no genome-wide characterization of admixture across Latin America has yet been attempted. Here, we report an analysis of admixt...

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Detalles Bibliográficos
Autores: Bailliet, Graciela, Bianchi, Néstor Oscar
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2008
País:Argentina
Institución:Universidad Nacional de La Plata
Repositorio:SEDICI (UNLP)
Idioma:inglés
OAI Identifier:oai:sedici.unlp.edu.ar:10915/83047
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/83047
Access Level:acceso abierto
Palabra clave:Biología
Antropología
Genética
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spelling Geographic patterns of genome admixture in latin American mestizosBailliet, GracielaBianchi, Néstor OscarBiologíaAntropologíaGenéticaThe large and diverse population of Latin America is potentially a powerful resource for elucidating the genetic basis of complex traits through admixture mapping. However, no genome-wide characterization of admixture across Latin America has yet been attempted. Here, we report an analysis of admixture in thirteen Mestizo populations (i.e. in regions of mainly European and Native settlement) from seven countries in Latin America based on data for 678 autosomal and 29 X-chromosome microsatellites. We found extensive variation in Native American and European ancestry (and generally low levels of African ancestry) among populations and individuals, and evidence that admixture across Latin America has often involved predominantly European men and both Native and African women. An admixture analysis allowing for Native American population subdivision revealed a differentiation of the Native American ancestry amongst Mestizos. This observation is consistent with the genetic structure of pre-Columbian populations and with admixture having involved Natives from the area where the Mestizo examined are located. Our findings agree with available information on the demographic history of Latin America and have a number of implications for the design of association studies in population from the region.La lista completa de autores que integran el documento puede consultarse en el archivo.Instituto Multidisciplinario de Biología Celular2008info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttp://sedici.unlp.edu.ar/handle/10915/83047enginfo:eu-repo/semantics/altIdentifier/issn/1553-7390info:eu-repo/semantics/altIdentifier/doi/10.1371/journal.pgen.1000037info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2024-05-08T12:53:43Zoai:sedici.unlp.edu.ar:10915/83047Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292024-05-08 12:53:44.074SEDICI (UNLP) - Universidad Nacional de La Platafalse
dc.title.none.fl_str_mv Geographic patterns of genome admixture in latin American mestizos
title Geographic patterns of genome admixture in latin American mestizos
spellingShingle Geographic patterns of genome admixture in latin American mestizos
Bailliet, Graciela
Biología
Antropología
Genética
title_short Geographic patterns of genome admixture in latin American mestizos
title_full Geographic patterns of genome admixture in latin American mestizos
title_fullStr Geographic patterns of genome admixture in latin American mestizos
title_full_unstemmed Geographic patterns of genome admixture in latin American mestizos
title_sort Geographic patterns of genome admixture in latin American mestizos
dc.creator.none.fl_str_mv Bailliet, Graciela
Bianchi, Néstor Oscar
author Bailliet, Graciela
author_facet Bailliet, Graciela
Bianchi, Néstor Oscar
author_role author
author2 Bianchi, Néstor Oscar
author2_role author
dc.subject.none.fl_str_mv Biología
Antropología
Genética
topic Biología
Antropología
Genética
description The large and diverse population of Latin America is potentially a powerful resource for elucidating the genetic basis of complex traits through admixture mapping. However, no genome-wide characterization of admixture across Latin America has yet been attempted. Here, we report an analysis of admixture in thirteen Mestizo populations (i.e. in regions of mainly European and Native settlement) from seven countries in Latin America based on data for 678 autosomal and 29 X-chromosome microsatellites. We found extensive variation in Native American and European ancestry (and generally low levels of African ancestry) among populations and individuals, and evidence that admixture across Latin America has often involved predominantly European men and both Native and African women. An admixture analysis allowing for Native American population subdivision revealed a differentiation of the Native American ancestry amongst Mestizos. This observation is consistent with the genetic structure of pre-Columbian populations and with admixture having involved Natives from the area where the Mestizo examined are located. Our findings agree with available information on the demographic history of Latin America and have a number of implications for the design of association studies in population from the region.
publishDate 2008
dc.date.none.fl_str_mv 2008
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info:eu-repo/semantics/publishedVersion
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dc.identifier.none.fl_str_mv http://sedici.unlp.edu.ar/handle/10915/83047
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dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/issn/1553-7390
info:eu-repo/semantics/altIdentifier/doi/10.1371/journal.pgen.1000037
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Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
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