Hematological parameters and globulin profile of Bothrops asper and Crotalus simus snakes (Serpentes: Viperidae), after the main venom gland removal

Snakebite accidents are a neglected tropical disease worldwide. In Costa Rica, the snakes Bothrops asper and Crotalus simus cause more than the 60% of the snakebite accidents already reported. To fight this neglected human disease, biomedical institutions need to manage live venomous snake collectio...

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Detalhes bibliográficos
Autores: Chang-Castillo, Arturo, Arguedas, Randall, Chacón, Danilo, Corrales, Greivin, Gómez, Aarón
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:Argentina
Recursos:Universidad Nacional de La Plata
Repositorio:SEDICI (UNLP)
Idioma:inglés
OAI Identifier:oai:sedici.unlp.edu.ar:10915/120241
Acesso em linha:http://sedici.unlp.edu.ar/handle/10915/120241
Access Level:acceso abierto
Palavra-chave:Zoología
Snake globulins
Snake hematology
Bothrops asper
Crotalus simus
Globulin profile
Venomoid snakes
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spelling Hematological parameters and globulin profile of Bothrops asper and Crotalus simus snakes (Serpentes: Viperidae), after the main venom gland removalChang-Castillo, ArturoArguedas, RandallChacón, DaniloCorrales, GreivinGómez, AarónZoologíaSnake globulinsSnake hematologyBothrops asperCrotalus simusGlobulin profileVenomoid snakesSnakebite accidents are a neglected tropical disease worldwide. In Costa Rica, the snakes Bothrops asper and Crotalus simus cause more than the 60% of the snakebite accidents already reported. To fight this neglected human disease, biomedical institutions need to manage live venomous snake collections in order to extract venoms and produce antivenoms. The welfare of the snakes in captivity must be guaranteed, especially in the case of old animals with defective venom production, which is a common situation at the Clodomiro Picado Institute. A surgical removal of the main venom glands was performed in five B. asper and C. simus with none or low venom production. The hematological parameters and plasma proteins of these individuals were analyzed pre-surgery and for 90 days post-surgery. Surgical procedures did not produce anemia during the post-surgical evaluation, but heterophilia, relative monocytosis and lymphopenia were detected one to three days afterwards. We conclude that the surgical removal of the main venom gland is a safe procedure and did not affect the snake’s health. Additionally, the use of electrophoretic determination of the albumin:globulin ratio to assess the health condition of the snakes is discussed. Finally, the relative monocytosis and lymphopenia seems to be linked to continuous handling of the snakes during consecutive days. Monocytes play a key role in the stress response, therefore the relative monocytosis and lymphopenia of leukogram reports should be interpreted in this context.Asociación Herpetológica Argentina2021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdf121-130http://sedici.unlp.edu.ar/handle/10915/120241enginfo:eu-repo/semantics/altIdentifier/url/https://ppct.caicyt.gov.ar/index.php/cuadherpetol/article/view/19055info:eu-repo/semantics/altIdentifier/issn/1852-5768info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc/2.5/ar/Creative Commons Attribution-NonCommercial 2.5 Argentina (CC BY-NC 2.5)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2024-05-08T13:06:32Zoai:sedici.unlp.edu.ar:10915/120241Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292024-05-08 13:06:32.5SEDICI (UNLP) - Universidad Nacional de La Platafalse
dc.title.none.fl_str_mv Hematological parameters and globulin profile of Bothrops asper and Crotalus simus snakes (Serpentes: Viperidae), after the main venom gland removal
title Hematological parameters and globulin profile of Bothrops asper and Crotalus simus snakes (Serpentes: Viperidae), after the main venom gland removal
spellingShingle Hematological parameters and globulin profile of Bothrops asper and Crotalus simus snakes (Serpentes: Viperidae), after the main venom gland removal
Chang-Castillo, Arturo
Zoología
Snake globulins
Snake hematology
Bothrops asper
Crotalus simus
Globulin profile
Venomoid snakes
title_short Hematological parameters and globulin profile of Bothrops asper and Crotalus simus snakes (Serpentes: Viperidae), after the main venom gland removal
title_full Hematological parameters and globulin profile of Bothrops asper and Crotalus simus snakes (Serpentes: Viperidae), after the main venom gland removal
title_fullStr Hematological parameters and globulin profile of Bothrops asper and Crotalus simus snakes (Serpentes: Viperidae), after the main venom gland removal
title_full_unstemmed Hematological parameters and globulin profile of Bothrops asper and Crotalus simus snakes (Serpentes: Viperidae), after the main venom gland removal
title_sort Hematological parameters and globulin profile of Bothrops asper and Crotalus simus snakes (Serpentes: Viperidae), after the main venom gland removal
dc.creator.none.fl_str_mv Chang-Castillo, Arturo
Arguedas, Randall
Chacón, Danilo
Corrales, Greivin
Gómez, Aarón
author Chang-Castillo, Arturo
author_facet Chang-Castillo, Arturo
Arguedas, Randall
Chacón, Danilo
Corrales, Greivin
Gómez, Aarón
author_role author
author2 Arguedas, Randall
Chacón, Danilo
Corrales, Greivin
Gómez, Aarón
author2_role author
author
author
author
dc.subject.none.fl_str_mv Zoología
Snake globulins
Snake hematology
Bothrops asper
Crotalus simus
Globulin profile
Venomoid snakes
topic Zoología
Snake globulins
Snake hematology
Bothrops asper
Crotalus simus
Globulin profile
Venomoid snakes
description Snakebite accidents are a neglected tropical disease worldwide. In Costa Rica, the snakes Bothrops asper and Crotalus simus cause more than the 60% of the snakebite accidents already reported. To fight this neglected human disease, biomedical institutions need to manage live venomous snake collections in order to extract venoms and produce antivenoms. The welfare of the snakes in captivity must be guaranteed, especially in the case of old animals with defective venom production, which is a common situation at the Clodomiro Picado Institute. A surgical removal of the main venom glands was performed in five B. asper and C. simus with none or low venom production. The hematological parameters and plasma proteins of these individuals were analyzed pre-surgery and for 90 days post-surgery. Surgical procedures did not produce anemia during the post-surgical evaluation, but heterophilia, relative monocytosis and lymphopenia were detected one to three days afterwards. We conclude that the surgical removal of the main venom gland is a safe procedure and did not affect the snake’s health. Additionally, the use of electrophoretic determination of the albumin:globulin ratio to assess the health condition of the snakes is discussed. Finally, the relative monocytosis and lymphopenia seems to be linked to continuous handling of the snakes during consecutive days. Monocytes play a key role in the stress response, therefore the relative monocytosis and lymphopenia of leukogram reports should be interpreted in this context.
publishDate 2021
dc.date.none.fl_str_mv 2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Articulo
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://sedici.unlp.edu.ar/handle/10915/120241
url http://sedici.unlp.edu.ar/handle/10915/120241
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://ppct.caicyt.gov.ar/index.php/cuadherpetol/article/view/19055
info:eu-repo/semantics/altIdentifier/issn/1852-5768
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc/2.5/ar/
Creative Commons Attribution-NonCommercial 2.5 Argentina (CC BY-NC 2.5)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc/2.5/ar/
Creative Commons Attribution-NonCommercial 2.5 Argentina (CC BY-NC 2.5)
dc.format.none.fl_str_mv application/pdf
121-130
dc.source.none.fl_str_mv reponame:SEDICI (UNLP)
instname:Universidad Nacional de La Plata
instacron:UNLP
instname_str Universidad Nacional de La Plata
instacron_str UNLP
institution UNLP
reponame_str SEDICI (UNLP)
collection SEDICI (UNLP)
repository.name.fl_str_mv SEDICI (UNLP) - Universidad Nacional de La Plata
repository.mail.fl_str_mv alira@sedici.unlp.edu.ar
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