Effect of structurally related flavonoids from Zuccagnia punctata Cav. on Caenorhabditis elegans

Zuccagnia punctata Cav. (Fabaceae), commonly called jarilla macho or pus-pus, is being used in traditional medicine as an antiseptic, anti-inflammatory and to relieve muscle and bone pain. The aim of this work was to study the anthelmintic effects of three structurally related flavonoids present in...

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Autores: D'almeida, Romina Elisa, Alberto, Maria Rosa, Morgan, Phillip, Sedensky, Margaret, Isla, Maria Ines
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2015
País:Argentina
Institución:Consejo Nacional de Investigaciones Científicas y Técnicas
Repositorio:CONICET Digital (CONICET)
Idioma:inglés
OAI Identifier:oai:ri.conicet.gov.ar:11336/40333
Acceso en línea:http://hdl.handle.net/11336/40333
Access Level:acceso abierto
Palabra clave:2″,4″-Dihydroxychalcone
3,7-Dihydroxyflavone
7-Hydroxyflavanone
Anthelmintic Effect
Caenorhabditis Elegans
https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
id AR_352ec3fbb55d38527261fdbc13e37a39
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repository_id_str
spelling Effect of structurally related flavonoids from Zuccagnia punctata Cav. on Caenorhabditis elegansD'almeida, Romina ElisaAlberto, Maria RosaMorgan, PhillipSedensky, MargaretIsla, Maria Ines2″,4″-Dihydroxychalcone3,7-Dihydroxyflavone7-HydroxyflavanoneAnthelmintic EffectCaenorhabditis Eleganshttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Zuccagnia punctata Cav. (Fabaceae), commonly called jarilla macho or pus-pus, is being used in traditional medicine as an antiseptic, anti-inflammatory and to relieve muscle and bone pain. The aim of this work was to study the anthelmintic effects of three structurally related flavonoids present in aerial parts of Z. punctata Cav. The biological activity of the flavonoids 7-hydroxyflavanone (HF), 3,7-dihydroxyflavone (DHF) and 2′,4′-dihydroxychalcone (DHC) was examined in the free-living nematode Caenorhabditis elegans. Our results showed that among the assayed flavonoids, only DHC showed an anthelmintic effect and alteration of egg hatching and larval development processes in C. elegans. DHC was able to kill 50% of adult nematodes at a concentration of 17 μg/mL. The effect on larval development was observed after 48 h in the presence of 25 and 50 μg/mL DHC, where 33.4 and 73.4% of nematodes remained in the L3 stage or younger. New therapeutic drugs with good efficacy against drug-resistant nematodes are urgently needed. Therefore, DHC, a natural compound present in Z. punctata, is proposed as a potential anthelmintic drug.Fil: D'almeida, Romina Elisa. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto de Química del Noroeste. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Química del Noroeste; ArgentinaFil: Alberto, Maria Rosa. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto de Química del Noroeste. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Química del Noroeste; ArgentinaFil: Morgan, Phillip. University of Washington; Estados UnidosFil: Sedensky, Margaret. University of Washington; Estados UnidosFil: Isla, Maria Ines. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto de Química del Noroeste. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Química del Noroeste; ArgentinaDe Gruyter2015-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/40333D'almeida, Romina Elisa; Alberto, Maria Rosa; Morgan, Phillip; Sedensky, Margaret; Isla, Maria Ines; Effect of structurally related flavonoids from Zuccagnia punctata Cav. on Caenorhabditis elegans; De Gruyter; Acta Parasitologica; 60; 1; 3-2015; 164-1721230-2821CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1515/ap-2015-0023info:eu-repo/semantics/altIdentifier/url/https://www.degruyter.com/view/j/ap.2015.60.issue-1/ap-2015-0023/ap-2015-0023.xmlinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2024-05-08T13:58:44Zoai:ri.conicet.gov.ar:11336/40333instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982024-05-08 13:58:44.349CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Effect of structurally related flavonoids from Zuccagnia punctata Cav. on Caenorhabditis elegans
title Effect of structurally related flavonoids from Zuccagnia punctata Cav. on Caenorhabditis elegans
spellingShingle Effect of structurally related flavonoids from Zuccagnia punctata Cav. on Caenorhabditis elegans
D'almeida, Romina Elisa
2″,4″-Dihydroxychalcone
3,7-Dihydroxyflavone
7-Hydroxyflavanone
Anthelmintic Effect
Caenorhabditis Elegans
https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
title_short Effect of structurally related flavonoids from Zuccagnia punctata Cav. on Caenorhabditis elegans
title_full Effect of structurally related flavonoids from Zuccagnia punctata Cav. on Caenorhabditis elegans
title_fullStr Effect of structurally related flavonoids from Zuccagnia punctata Cav. on Caenorhabditis elegans
title_full_unstemmed Effect of structurally related flavonoids from Zuccagnia punctata Cav. on Caenorhabditis elegans
title_sort Effect of structurally related flavonoids from Zuccagnia punctata Cav. on Caenorhabditis elegans
dc.creator.none.fl_str_mv D'almeida, Romina Elisa
Alberto, Maria Rosa
Morgan, Phillip
Sedensky, Margaret
Isla, Maria Ines
author D'almeida, Romina Elisa
author_facet D'almeida, Romina Elisa
Alberto, Maria Rosa
Morgan, Phillip
Sedensky, Margaret
Isla, Maria Ines
author_role author
author2 Alberto, Maria Rosa
Morgan, Phillip
Sedensky, Margaret
Isla, Maria Ines
author2_role author
author
author
author
dc.subject.none.fl_str_mv 2″,4″-Dihydroxychalcone
3,7-Dihydroxyflavone
7-Hydroxyflavanone
Anthelmintic Effect
Caenorhabditis Elegans
https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
topic 2″,4″-Dihydroxychalcone
3,7-Dihydroxyflavone
7-Hydroxyflavanone
Anthelmintic Effect
Caenorhabditis Elegans
https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
description Zuccagnia punctata Cav. (Fabaceae), commonly called jarilla macho or pus-pus, is being used in traditional medicine as an antiseptic, anti-inflammatory and to relieve muscle and bone pain. The aim of this work was to study the anthelmintic effects of three structurally related flavonoids present in aerial parts of Z. punctata Cav. The biological activity of the flavonoids 7-hydroxyflavanone (HF), 3,7-dihydroxyflavone (DHF) and 2′,4′-dihydroxychalcone (DHC) was examined in the free-living nematode Caenorhabditis elegans. Our results showed that among the assayed flavonoids, only DHC showed an anthelmintic effect and alteration of egg hatching and larval development processes in C. elegans. DHC was able to kill 50% of adult nematodes at a concentration of 17 μg/mL. The effect on larval development was observed after 48 h in the presence of 25 and 50 μg/mL DHC, where 33.4 and 73.4% of nematodes remained in the L3 stage or younger. New therapeutic drugs with good efficacy against drug-resistant nematodes are urgently needed. Therefore, DHC, a natural compound present in Z. punctata, is proposed as a potential anthelmintic drug.
publishDate 2015
dc.date.none.fl_str_mv 2015-03
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/40333
D'almeida, Romina Elisa; Alberto, Maria Rosa; Morgan, Phillip; Sedensky, Margaret; Isla, Maria Ines; Effect of structurally related flavonoids from Zuccagnia punctata Cav. on Caenorhabditis elegans; De Gruyter; Acta Parasitologica; 60; 1; 3-2015; 164-172
1230-2821
CONICET Digital
CONICET
url http://hdl.handle.net/11336/40333
identifier_str_mv D'almeida, Romina Elisa; Alberto, Maria Rosa; Morgan, Phillip; Sedensky, Margaret; Isla, Maria Ines; Effect of structurally related flavonoids from Zuccagnia punctata Cav. on Caenorhabditis elegans; De Gruyter; Acta Parasitologica; 60; 1; 3-2015; 164-172
1230-2821
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1515/ap-2015-0023
info:eu-repo/semantics/altIdentifier/url/https://www.degruyter.com/view/j/ap.2015.60.issue-1/ap-2015-0023/ap-2015-0023.xml
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv De Gruyter
publisher.none.fl_str_mv De Gruyter
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 15,812429

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