Progesterone attenuates several hippocampal abnormalities of the Wobbler mouse

It is now recognised that progesterone plays a protective role for diseases of the central nervous system. In the Wobbler mouse, a model of motoneurone degeneration, progesterone treatment prevents spinal cord neuropathology and clinical progression of the disease. However, neuropathological and fun...

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Autores: Meyer, Maria, Gonzalez Deniselle, Maria Claudia, Gargiulo Monachelli, Gisella Mariana, Lima, Analia Ethel, Roig, Paulina, Guennoun, Rachida, Schumacher, Michael, de Nicola, Alejandro Federico
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2013
País:Argentina
Recursos:Consejo Nacional de Investigaciones Científicas y Técnicas
Repositorio:CONICET Digital (CONICET)
Idioma:inglés
OAI Identifier:oai:ri.conicet.gov.ar:11336/21413
Acesso em linha:http://hdl.handle.net/11336/21413
Access Level:acceso abierto
Palavra-chave:Progesterone
Hippocampus
Wobbler
Central Nervous System
Bdnf
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
id AR_34fceecb24e892d6cd7065f029411b3e
oai_identifier_str oai:ri.conicet.gov.ar:11336/21413
network_acronym_str AR
network_name_str Argentina
repository_id_str
dc.title.none.fl_str_mv Progesterone attenuates several hippocampal abnormalities of the Wobbler mouse
title Progesterone attenuates several hippocampal abnormalities of the Wobbler mouse
spellingShingle Progesterone attenuates several hippocampal abnormalities of the Wobbler mouse
Meyer, Maria
Progesterone
Hippocampus
Wobbler
Central Nervous System
Bdnf
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
title_short Progesterone attenuates several hippocampal abnormalities of the Wobbler mouse
title_full Progesterone attenuates several hippocampal abnormalities of the Wobbler mouse
title_fullStr Progesterone attenuates several hippocampal abnormalities of the Wobbler mouse
title_full_unstemmed Progesterone attenuates several hippocampal abnormalities of the Wobbler mouse
title_sort Progesterone attenuates several hippocampal abnormalities of the Wobbler mouse
dc.creator.none.fl_str_mv Meyer, Maria
Gonzalez Deniselle, Maria Claudia
Gargiulo Monachelli, Gisella Mariana
Lima, Analia Ethel
Roig, Paulina
Guennoun, Rachida
Schumacher, Michael
de Nicola, Alejandro Federico
author Meyer, Maria
author_facet Meyer, Maria
Gonzalez Deniselle, Maria Claudia
Gargiulo Monachelli, Gisella Mariana
Lima, Analia Ethel
Roig, Paulina
Guennoun, Rachida
Schumacher, Michael
de Nicola, Alejandro Federico
author_role author
author2 Gonzalez Deniselle, Maria Claudia
Gargiulo Monachelli, Gisella Mariana
Lima, Analia Ethel
Roig, Paulina
Guennoun, Rachida
Schumacher, Michael
de Nicola, Alejandro Federico
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Progesterone
Hippocampus
Wobbler
Central Nervous System
Bdnf
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
topic Progesterone
Hippocampus
Wobbler
Central Nervous System
Bdnf
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
description It is now recognised that progesterone plays a protective role for diseases of the central nervous system. In the Wobbler mouse, a model of motoneurone degeneration, progesterone treatment prevents spinal cord neuropathology and clinical progression of the disease. However, neuropathological and functional abnormalities have also been discovered in the brain of Wobbler mice and patients with amyotrophic lateral sclerosis. The present study examined the hippocampus of control and afflicted Wobbler mice and the changes in response to progesterone treatment. Mice received either a single progesterone implant (20 mg for 18 days). We found that the hippocampal pathology of the untreated Wobblers involved a decreased expression of brain-derived neurotrophic factor (BDNF) mRNA, decreased astrogliosis in the stratum lucidum, stratum radiatum and stratum lacunosum-moleculare, decreased doublecortin (DCX)-positive neuroblasts in the subgranular zone of the dentate gyrus and a decreased density of GABA immunoreactive hippocampal interneurones and granule cells of the dentate gyrus. Although progesterone did not change the normal parameters of control mice, it attenuated several hippocampal abnormalities in Wobblers. Thus, progesterone increased hippocampal BDNF mRNA expression, decreased glial fibrillary acidic protein-positive astrocytes and increased the number of GABAergic interneurones and granule cells. The number of DCX expressing neuroblasts and immature neurones remained impaired in both progesterone-treated and untreated Wobblers. In conclusion, progesterone treatment exerted beneficial effects on some aspects of hippocampal neuropathology, suggesting its neuroprotective role in the brain, in agreement with previous data obtained in the spinal cord of Wobbler mice.
publishDate 2013
dc.date.none.fl_str_mv 2013-02-24
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/21413
Meyer, Maria; Gonzalez Deniselle, Maria Claudia; Gargiulo Monachelli, Gisella Mariana; Lima, Analia Ethel; Roig, Paulina; et al.; Progesterone attenuates several hippocampal abnormalities of the Wobbler mouse; Wiley; Journal of Neuroendocrinology; 25; 3; 24-2-2013; 235-243
1365-2826
1365-2826
CONICET Digital
CONICET
url http://hdl.handle.net/11336/21413
identifier_str_mv Meyer, Maria; Gonzalez Deniselle, Maria Claudia; Gargiulo Monachelli, Gisella Mariana; Lima, Analia Ethel; Roig, Paulina; et al.; Progesterone attenuates several hippocampal abnormalities of the Wobbler mouse; Wiley; Journal of Neuroendocrinology; 25; 3; 24-2-2013; 235-243
1365-2826
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1111/jne.12004
info:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1111/jne.12004
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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spelling Progesterone attenuates several hippocampal abnormalities of the Wobbler mouseMeyer, MariaGonzalez Deniselle, Maria ClaudiaGargiulo Monachelli, Gisella MarianaLima, Analia EthelRoig, PaulinaGuennoun, RachidaSchumacher, Michaelde Nicola, Alejandro FedericoProgesteroneHippocampusWobblerCentral Nervous SystemBdnfhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3It is now recognised that progesterone plays a protective role for diseases of the central nervous system. In the Wobbler mouse, a model of motoneurone degeneration, progesterone treatment prevents spinal cord neuropathology and clinical progression of the disease. However, neuropathological and functional abnormalities have also been discovered in the brain of Wobbler mice and patients with amyotrophic lateral sclerosis. The present study examined the hippocampus of control and afflicted Wobbler mice and the changes in response to progesterone treatment. Mice received either a single progesterone implant (20 mg for 18 days). We found that the hippocampal pathology of the untreated Wobblers involved a decreased expression of brain-derived neurotrophic factor (BDNF) mRNA, decreased astrogliosis in the stratum lucidum, stratum radiatum and stratum lacunosum-moleculare, decreased doublecortin (DCX)-positive neuroblasts in the subgranular zone of the dentate gyrus and a decreased density of GABA immunoreactive hippocampal interneurones and granule cells of the dentate gyrus. Although progesterone did not change the normal parameters of control mice, it attenuated several hippocampal abnormalities in Wobblers. Thus, progesterone increased hippocampal BDNF mRNA expression, decreased glial fibrillary acidic protein-positive astrocytes and increased the number of GABAergic interneurones and granule cells. The number of DCX expressing neuroblasts and immature neurones remained impaired in both progesterone-treated and untreated Wobblers. In conclusion, progesterone treatment exerted beneficial effects on some aspects of hippocampal neuropathology, suggesting its neuroprotective role in the brain, in agreement with previous data obtained in the spinal cord of Wobbler mice.Fil: Meyer, Maria. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Gonzalez Deniselle, Maria Claudia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquímica Humana; ArgentinaFil: Gargiulo Monachelli, Gisella Mariana. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Lima, Analia Ethel. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Roig, Paulina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Guennoun, Rachida. Inserm; FranciaFil: Schumacher, Michael. Inserm; FranciaFil: de Nicola, Alejandro Federico. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquímica Humana; ArgentinaWiley2013-02-24info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/21413Meyer, Maria; Gonzalez Deniselle, Maria Claudia; Gargiulo Monachelli, Gisella Mariana; Lima, Analia Ethel; Roig, Paulina; et al.; Progesterone attenuates several hippocampal abnormalities of the Wobbler mouse; Wiley; Journal of Neuroendocrinology; 25; 3; 24-2-2013; 235-2431365-28261365-2826CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1111/jne.12004info:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1111/jne.12004info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2024-05-08T14:23:03Zoai:ri.conicet.gov.ar:11336/21413instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982024-05-08 14:23:03.377CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
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