Understanding the relationship between Mycobacterium bovis spoligotypes from cattle in Latin American Countries

Spoligotyping is the most frequently used method for genotyping isolates of Mycobacterium bovis worldwide. In the current work, we compared spoligotypes from 1684 M. bovis isolates from Argentina (816), Brazil (412), Chile (66), Mexico (274) and Venezuela (116), obtained from cattle, humans, pigs, w...

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Detalles Bibliográficos
Autores: Zumárraga, Martín José, Arriaga, C., Barandiaran, Soledad, Cobos Marín, Laura, de Waard, Jacobus, Estrada García, Inés, Figueiredo, T., Figueroa, A., Giménez, F., Gomes, H. M., Gonzalez y Merchand, J. A., Macías, Analía, Milián Suazo, Feliciano, Rodríguez, C. A. R., Santillán, M. A., Suffys, P. N., Trangoni, M. D., Zárraga, A. M., Cataldi, Ángel Adrián
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2012
País:Argentina
Institución:Consejo Nacional de Investigaciones Científicas y Técnicas
Repositorio:CONICET Digital (CONICET)
Idioma:inglés
OAI Identifier:oai:ri.conicet.gov.ar:11336/22825
Acceso en línea:http://hdl.handle.net/11336/22825
Access Level:acceso abierto
Palabra clave:Bovine Tuberculosis
Mycobacterium Bovis
Spoligotyping
Clusters
https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
https://purl.org/becyt/ford/4.3
https://purl.org/becyt/ford/4
Descripción
Sumario:Spoligotyping is the most frequently used method for genotyping isolates of Mycobacterium bovis worldwide. In the current work, we compared spoligotypes from 1684 M. bovis isolates from Argentina (816), Brazil (412), Chile (66), Mexico (274) and Venezuela (116), obtained from cattle, humans, pigs, wild boars, farmed deer, goats, buffaloes, cats, and wild animals. A total of 269 different spoligotypes were found: 142 (8.4%) isolates presented orphan spoligotypes, whereas 1542 (91.6%) formed 113 different clusters. In cattle, SB0140 was the most representative spoligotype with 355 (24.6%) isolates, followed by SB0121 with 149 (10.3%) isolates. Clustering of spoligotypes ranged from 95.2% in Argentina to 85.3% in Mexico. Orphan spoligotypes were also variable, ranging from 23.7% in Mexico to 4.1% in Brazil. A large proportion of spoligotypes were common to the neighboring countries Argentina, Brazil and Chile. In conclusion, despite the diversity of spoligotypes found in the five countries studied, there are major patterns that predominate in these neighboring countries. These clusters may reflect a long-lasting active transmission of bovine tuberculosis or common historical origins of infection.

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