Effect of particle size, polydispersity and polymer degradation on progesterone release from PLGA microparticles: Experimental and mathematical modeling

Poly(lactic-co-glycolic acid) (PLGA) microparticles containing progesterone were prepared by the solvent extraction/evaporation and microfluidic techniques. Microparticles were characterized by their size distribution, encapsulation efficiency, morphology and thermal properties. The effect of partic...

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Authors: Busatto, Carlos Alberto, Pesoa, Juan Ignacio, Helbling, Ignacio Marcelo, Luna, Julio Alberto, Estenoz, Diana Alejandra
Format: article
Status:Published version
Publication Date:2017
Country:Argentina
Institution:Consejo Nacional de Investigaciones Científicas y Técnicas
Repository:CONICET Digital (CONICET)
Language:English
OAI Identifier:oai:ri.conicet.gov.ar:11336/34433
Online Access:http://hdl.handle.net/11336/34433
Access Level:Open access
Keyword:DRUG DELIVERY
MATHEMATICAL MODELING
MICROPARTICLES
POLY(LACTIC-CO-GLYCOLIC ACID)
PROGESTERONE
https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
id AR_32bb40b8564b2cad5e441d848e3a6793
oai_identifier_str oai:ri.conicet.gov.ar:11336/34433
network_acronym_str AR
network_name_str Argentina
repository_id_str
dc.title.none.fl_str_mv Effect of particle size, polydispersity and polymer degradation on progesterone release from PLGA microparticles: Experimental and mathematical modeling
title Effect of particle size, polydispersity and polymer degradation on progesterone release from PLGA microparticles: Experimental and mathematical modeling
spellingShingle Effect of particle size, polydispersity and polymer degradation on progesterone release from PLGA microparticles: Experimental and mathematical modeling
Busatto, Carlos Alberto
DRUG DELIVERY
MATHEMATICAL MODELING
MICROPARTICLES
POLY(LACTIC-CO-GLYCOLIC ACID)
PROGESTERONE
https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
title_short Effect of particle size, polydispersity and polymer degradation on progesterone release from PLGA microparticles: Experimental and mathematical modeling
title_full Effect of particle size, polydispersity and polymer degradation on progesterone release from PLGA microparticles: Experimental and mathematical modeling
title_fullStr Effect of particle size, polydispersity and polymer degradation on progesterone release from PLGA microparticles: Experimental and mathematical modeling
title_full_unstemmed Effect of particle size, polydispersity and polymer degradation on progesterone release from PLGA microparticles: Experimental and mathematical modeling
title_sort Effect of particle size, polydispersity and polymer degradation on progesterone release from PLGA microparticles: Experimental and mathematical modeling
dc.creator.none.fl_str_mv Busatto, Carlos Alberto
Pesoa, Juan Ignacio
Helbling, Ignacio Marcelo
Luna, Julio Alberto
Estenoz, Diana Alejandra
author Busatto, Carlos Alberto
author_facet Busatto, Carlos Alberto
Pesoa, Juan Ignacio
Helbling, Ignacio Marcelo
Luna, Julio Alberto
Estenoz, Diana Alejandra
author_role author
author2 Pesoa, Juan Ignacio
Helbling, Ignacio Marcelo
Luna, Julio Alberto
Estenoz, Diana Alejandra
author2_role author
author
author
author
dc.subject.none.fl_str_mv DRUG DELIVERY
MATHEMATICAL MODELING
MICROPARTICLES
POLY(LACTIC-CO-GLYCOLIC ACID)
PROGESTERONE
https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
topic DRUG DELIVERY
MATHEMATICAL MODELING
MICROPARTICLES
POLY(LACTIC-CO-GLYCOLIC ACID)
PROGESTERONE
https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
description Poly(lactic-co-glycolic acid) (PLGA) microparticles containing progesterone were prepared by the solvent extraction/evaporation and microfluidic techniques. Microparticles were characterized by their size distribution, encapsulation efficiency, morphology and thermal properties. The effect of particle size, polydispersity and polymer degradation on the in vitro release of the hormone was studied. A triphasic release profile was observed for larger microparticles, while smaller microspheres showed a biphasic release profile. This behavior is related to the fact that complete drug release was achieved in a few days for smaller microparticles, during which polymer degradation effects are still negligible. A mathematical model was developed that predicts the progesterone release profiles from different-sized PLGA microspheres. The model takes into account both the dissolution and diffusion of the drug in the polymeric matrix as well as the autocatalytic effect of polymer degradation. The model was adjusted and validated with novel experimental data. Simulation results are in very good agreement with experimental results.
publishDate 2017
dc.date.none.fl_str_mv 2017-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/34433
Busatto, Carlos Alberto; Pesoa, Juan Ignacio; Helbling, Ignacio Marcelo; Luna, Julio Alberto; Estenoz, Diana Alejandra; Effect of particle size, polydispersity and polymer degradation on progesterone release from PLGA microparticles: Experimental and mathematical modeling; Elsevier Science; International Journal Of Pharmaceutics; 536; 1; 12-2017; 360-369
0378-5173
CONICET Digital
CONICET
url http://hdl.handle.net/11336/34433
identifier_str_mv Busatto, Carlos Alberto; Pesoa, Juan Ignacio; Helbling, Ignacio Marcelo; Luna, Julio Alberto; Estenoz, Diana Alejandra; Effect of particle size, polydispersity and polymer degradation on progesterone release from PLGA microparticles: Experimental and mathematical modeling; Elsevier Science; International Journal Of Pharmaceutics; 536; 1; 12-2017; 360-369
0378-5173
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://linkinghub.elsevier.com/retrieve/pii/S037851731731133X
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.ijpharm.2017.12.006
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science
publisher.none.fl_str_mv Elsevier Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1799194848291454976
spelling Effect of particle size, polydispersity and polymer degradation on progesterone release from PLGA microparticles: Experimental and mathematical modelingBusatto, Carlos AlbertoPesoa, Juan IgnacioHelbling, Ignacio MarceloLuna, Julio AlbertoEstenoz, Diana AlejandraDRUG DELIVERYMATHEMATICAL MODELINGMICROPARTICLESPOLY(LACTIC-CO-GLYCOLIC ACID)PROGESTERONEhttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1Poly(lactic-co-glycolic acid) (PLGA) microparticles containing progesterone were prepared by the solvent extraction/evaporation and microfluidic techniques. Microparticles were characterized by their size distribution, encapsulation efficiency, morphology and thermal properties. The effect of particle size, polydispersity and polymer degradation on the in vitro release of the hormone was studied. A triphasic release profile was observed for larger microparticles, while smaller microspheres showed a biphasic release profile. This behavior is related to the fact that complete drug release was achieved in a few days for smaller microparticles, during which polymer degradation effects are still negligible. A mathematical model was developed that predicts the progesterone release profiles from different-sized PLGA microspheres. The model takes into account both the dissolution and diffusion of the drug in the polymeric matrix as well as the autocatalytic effect of polymer degradation. The model was adjusted and validated with novel experimental data. Simulation results are in very good agreement with experimental results.Fil: Busatto, Carlos Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; ArgentinaFil: Pesoa, Juan Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; ArgentinaFil: Helbling, Ignacio Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; ArgentinaFil: Luna, Julio Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; ArgentinaFil: Estenoz, Diana Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; ArgentinaElsevier Science2017-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/34433Busatto, Carlos Alberto; Pesoa, Juan Ignacio; Helbling, Ignacio Marcelo; Luna, Julio Alberto; Estenoz, Diana Alejandra; Effect of particle size, polydispersity and polymer degradation on progesterone release from PLGA microparticles: Experimental and mathematical modeling; Elsevier Science; International Journal Of Pharmaceutics; 536; 1; 12-2017; 360-3690378-5173CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://linkinghub.elsevier.com/retrieve/pii/S037851731731133Xinfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.ijpharm.2017.12.006info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2024-05-08T13:37:46Zoai:ri.conicet.gov.ar:11336/34433instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982024-05-08 13:37:46.507CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
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