Heat stress induces ferroptosis-like cell death in plants

In plants, regulated cell death (RCD) plays critical roles during development and is essential for plant-specifi responses to abiotic and biotic stresses. Ferroptosis is an iron-dependent, oxidative, nonapoptotic form of cell death recently described in animal cells. In animal cells, this process ca...

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Detalhes bibliográficos
Autores: Distefano, Ayelen Mariana, Martin, María Victoria, Cordoba, Juan Pablo, Bellido, Andres, D'ippólito, Sebastián, Colman, Silvana Lorena, Soto, Débora, Roldán, Juan Alfredo, Bartoli, Carlos Guillermo, Zabaleta, Eduardo Julian, Fiol, Diego Fernando, Stockwell, Brent, Dixon, Scott, Pagnussat, Gabriela Carolina
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2017
País:Argentina
Recursos:Consejo Nacional de Investigaciones Científicas y Técnicas
Repositorio:CONICET Digital (CONICET)
Idioma:inglés
OAI Identifier:oai:ri.conicet.gov.ar:11336/65506
Acesso em linha:http://hdl.handle.net/11336/65506
Access Level:acceso abierto
Palavra-chave:FERROPTOSIS
PLANTS
CELL DEATH
HEAT STRESS
https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
Descrição
Resumo:In plants, regulated cell death (RCD) plays critical roles during development and is essential for plant-specifi responses to abiotic and biotic stresses. Ferroptosis is an iron-dependent, oxidative, nonapoptotic form of cell death recently described in animal cells. In animal cells, this process can be triggered by depletion of glutathione (GSH) and accumulation of lipid reactive oxygen species (ROS). We investigated whether a similar process could be relevant to cell death in plants. Remarkably, heat shock (HS)-induced RCD, but not reproductive or vascular development, was found to involve a ferroptosis-like cell death process. In root cells, HS triggered an iron-dependent cell death pathway that was characterized by depletion of GSH and ascorbic acid and accumulation of cytosolic and lipid ROS. These results suggest a physiological role for this lethal pathway in response to heat stress in Arabidopsis thaliana. The similarity of ferroptosis in animal cells and ferroptosis-like death in plants suggests that oxidative, iron-dependent cell death programs may be evolutionarily ancient.

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