Ontogenetic growth of multicellular tumor spheroids
In ontogenetic growth models, the basal metabolic rate is usually assumed to depend on the individual mass following a power law. Here it is shown that, in the case of multicellular tumor spheroids, the emergence of a necrotic core invalidates this assumption. The implications of this result for sph...
| Autores: | , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2006 |
| País: | Argentina |
| Institución: | Consejo Nacional de Investigaciones Científicas y Técnicas |
| Repositorio: | CONICET Digital (CONICET) |
| Idioma: | inglés |
| OAI Identifier: | oai:ri.conicet.gov.ar:11336/132356 |
| Acceso en línea: | http://hdl.handle.net/11336/132356 |
| Access Level: | acceso abierto |
| Palabra clave: | CANCER DIFFUSION MULTICELLULAR TUMOR SPHEROID NECROSIS ONTOGENETIC GROWTH https://purl.org/becyt/ford/1.3 https://purl.org/becyt/ford/1 |
| Sumario: | In ontogenetic growth models, the basal metabolic rate is usually assumed to depend on the individual mass following a power law. Here it is shown that, in the case of multicellular tumor spheroids, the emergence of a necrotic core invalidates this assumption. The implications of this result for spheroid growth are discussed, and a procedure to determine the growth parameters using macroscopic measurements is proposed. |
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