Cascade cyclization triggered by imine formation. Formal synthesis of the alkaloid (±)-stemoamide and its 9a-epimer
A concise formal synthesis of stemoamide ( 1) and its 9a-epimer 14in 5 steps is described featuring a cas-cade cyclization triggered by imine formation. A good selectivity for either epimer is readily accom-plished by variation of the ester ( 9bor 9a, respectively) and the reaction conditions.
| Autores: | , , , |
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| Formato: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2015 |
| País: | Argentina |
| Recursos: | Consejo Nacional de Investigaciones Científicas y Técnicas |
| Repositorio: | CONICET Digital (CONICET) |
| Idioma: | inglés |
| OAI Identifier: | oai:ri.conicet.gov.ar:11336/5987 |
| Acesso em linha: | http://hdl.handle.net/11336/5987 |
| Access Level: | acceso abierto |
| Palavra-chave: | Cascade Cyclization Imine Formal Synthesis Stemoamide https://purl.org/becyt/ford/1.4 https://purl.org/becyt/ford/1 |
| Resumo: | A concise formal synthesis of stemoamide ( 1) and its 9a-epimer 14in 5 steps is described featuring a cas-cade cyclization triggered by imine formation. A good selectivity for either epimer is readily accom-plished by variation of the ester ( 9bor 9a, respectively) and the reaction conditions. |
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