Naloxone and Baclofen Attenuate Ethanol's locomotor-activating effects in preweanling Sprague-Dawley Rats

Heterogeneous rat strains appear to be particularly sensitive to the sedative effects of ethanol as adults and insensitive to ethanol's stimulant effects. Recently, the authors found that ethanol induces stimulant effects in preweanling Sprague-Dawley rats. In adult mice, these effects seem to...

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Detalles Bibliográficos
Autores: Arias, Carlos, Mlewski, Estela Cecilia, Molina, Juan Carlos, Spear, Ne
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2009
País:Argentina
Institución:Consejo Nacional de Investigaciones Científicas y Técnicas
Repositorio:CONICET Digital (CONICET)
Idioma:inglés
OAI Identifier:oai:ri.conicet.gov.ar:11336/55922
Acceso en línea:http://hdl.handle.net/11336/55922
Access Level:acceso abierto
Palabra clave:Baclofen
Ethanol
Infant Rat
Naloxone
Stimulation
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
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network_acronym_str AR
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repository_id_str
spelling Naloxone and Baclofen Attenuate Ethanol's locomotor-activating effects in preweanling Sprague-Dawley RatsArias, CarlosMlewski, Estela CeciliaMolina, Juan CarlosSpear, NeBaclofenEthanolInfant RatNaloxoneStimulationhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Heterogeneous rat strains appear to be particularly sensitive to the sedative effects of ethanol as adults and insensitive to ethanol's stimulant effects. Recently, the authors found that ethanol induces stimulant effects in preweanling Sprague-Dawley rats. In adult mice, these effects seem to be governed by the mesocorticolimbic dopaminergic pathway, which can be modulated by means of GABA B agonist (baclofen) or opioid antagonist (naloxone) treatments. This study tested whether these pharmacological treatments might reduce the activating effect of ethanol in preweanling Sprague-Dawley rats. Twelve-day-old pups given naloxone (Experiment 1A) or baclofen (Experiment 1B) before ethanol administration were tested in terms of locomotor activity in a novel environment. Naloxone and baclofen significantly reduced the stimulating effect of ethanol but had no effect on locomotor activity patterns in water-treated controls. Blood ethanol levels were not affected by naloxone or baclofen (Experiment 2). During the preweanling period, opioid and GABA B receptors seem to be involved in the stimulating effect of ethanol. © 2009 American Psychological Association.Fil: Arias, Carlos. University Of Binghamton; Estados UnidosFil: Mlewski, Estela Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Centro de Investigaciones en Ciencias de la Tierra. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Centro de Investigaciones en Ciencias de la Tierra; ArgentinaFil: Molina, Juan Carlos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina. University Of Binghamton; Estados UnidosFil: Spear, Ne. University Of Binghamton; Estados UnidosAmerican Psychological Association2009-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/55922Arias, Carlos; Mlewski, Estela Cecilia; Molina, Juan Carlos; Spear, Ne; Naloxone and Baclofen Attenuate Ethanol's locomotor-activating effects in preweanling Sprague-Dawley Rats; American Psychological Association; Behavioral Neuroscience.; 123; 1; 2-2009; 172-1800735-70441939-0084CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://psycnet.apa.org/doiLanding?doi=10.1037%2Fa0014049info:eu-repo/semantics/altIdentifier/doi/10.1037/a0014049info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2024-05-08T13:54:50Zoai:ri.conicet.gov.ar:11336/55922instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982024-05-08 13:54:50.678CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Naloxone and Baclofen Attenuate Ethanol's locomotor-activating effects in preweanling Sprague-Dawley Rats
title Naloxone and Baclofen Attenuate Ethanol's locomotor-activating effects in preweanling Sprague-Dawley Rats
spellingShingle Naloxone and Baclofen Attenuate Ethanol's locomotor-activating effects in preweanling Sprague-Dawley Rats
Arias, Carlos
Baclofen
Ethanol
Infant Rat
Naloxone
Stimulation
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
title_short Naloxone and Baclofen Attenuate Ethanol's locomotor-activating effects in preweanling Sprague-Dawley Rats
title_full Naloxone and Baclofen Attenuate Ethanol's locomotor-activating effects in preweanling Sprague-Dawley Rats
title_fullStr Naloxone and Baclofen Attenuate Ethanol's locomotor-activating effects in preweanling Sprague-Dawley Rats
title_full_unstemmed Naloxone and Baclofen Attenuate Ethanol's locomotor-activating effects in preweanling Sprague-Dawley Rats
title_sort Naloxone and Baclofen Attenuate Ethanol's locomotor-activating effects in preweanling Sprague-Dawley Rats
dc.creator.none.fl_str_mv Arias, Carlos
Mlewski, Estela Cecilia
Molina, Juan Carlos
Spear, Ne
author Arias, Carlos
author_facet Arias, Carlos
Mlewski, Estela Cecilia
Molina, Juan Carlos
Spear, Ne
author_role author
author2 Mlewski, Estela Cecilia
Molina, Juan Carlos
Spear, Ne
author2_role author
author
author
dc.subject.none.fl_str_mv Baclofen
Ethanol
Infant Rat
Naloxone
Stimulation
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
topic Baclofen
Ethanol
Infant Rat
Naloxone
Stimulation
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
description Heterogeneous rat strains appear to be particularly sensitive to the sedative effects of ethanol as adults and insensitive to ethanol's stimulant effects. Recently, the authors found that ethanol induces stimulant effects in preweanling Sprague-Dawley rats. In adult mice, these effects seem to be governed by the mesocorticolimbic dopaminergic pathway, which can be modulated by means of GABA B agonist (baclofen) or opioid antagonist (naloxone) treatments. This study tested whether these pharmacological treatments might reduce the activating effect of ethanol in preweanling Sprague-Dawley rats. Twelve-day-old pups given naloxone (Experiment 1A) or baclofen (Experiment 1B) before ethanol administration were tested in terms of locomotor activity in a novel environment. Naloxone and baclofen significantly reduced the stimulating effect of ethanol but had no effect on locomotor activity patterns in water-treated controls. Blood ethanol levels were not affected by naloxone or baclofen (Experiment 2). During the preweanling period, opioid and GABA B receptors seem to be involved in the stimulating effect of ethanol. © 2009 American Psychological Association.
publishDate 2009
dc.date.none.fl_str_mv 2009-02
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/55922
Arias, Carlos; Mlewski, Estela Cecilia; Molina, Juan Carlos; Spear, Ne; Naloxone and Baclofen Attenuate Ethanol's locomotor-activating effects in preweanling Sprague-Dawley Rats; American Psychological Association; Behavioral Neuroscience.; 123; 1; 2-2009; 172-180
0735-7044
1939-0084
CONICET Digital
CONICET
url http://hdl.handle.net/11336/55922
identifier_str_mv Arias, Carlos; Mlewski, Estela Cecilia; Molina, Juan Carlos; Spear, Ne; Naloxone and Baclofen Attenuate Ethanol's locomotor-activating effects in preweanling Sprague-Dawley Rats; American Psychological Association; Behavioral Neuroscience.; 123; 1; 2-2009; 172-180
0735-7044
1939-0084
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://psycnet.apa.org/doiLanding?doi=10.1037%2Fa0014049
info:eu-repo/semantics/altIdentifier/doi/10.1037/a0014049
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv American Psychological Association
publisher.none.fl_str_mv American Psychological Association
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 15,811543

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