Alterations of LXRα and LXRβ expression in the hypothalamus of glucose-intolerant rats

Liver X receptor (LXR) a and b are nuclear receptors that are crucial for the regulation of carbohydrate and lipid metabolism. Activation of LXRs in the brain facilitates cholesterol clearance and improves cognitive deficits, thus they are considered as promising drug targets to treat diseases such...

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Autores: Kruse, Maria Sol, Rey, Mariana, Vega, Maria Cristina, Coirini, Hector
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2012
País:Argentina
Institución:Consejo Nacional de Investigaciones Científicas y Técnicas
Repositorio:CONICET Digital (CONICET)
Idioma:inglés
OAI Identifier:oai:ri.conicet.gov.ar:11336/22184
Acceso en línea:http://hdl.handle.net/11336/22184
Access Level:acceso abierto
Palabra clave:Lxr Receptors
Glucose Intolerant
Hypothalamus
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
id AR_2e5bbeb108994bd83fc09faeba30c21f
oai_identifier_str oai:ri.conicet.gov.ar:11336/22184
network_acronym_str AR
network_name_str Argentina
repository_id_str
dc.title.none.fl_str_mv Alterations of LXRα and LXRβ expression in the hypothalamus of glucose-intolerant rats
title Alterations of LXRα and LXRβ expression in the hypothalamus of glucose-intolerant rats
spellingShingle Alterations of LXRα and LXRβ expression in the hypothalamus of glucose-intolerant rats
Kruse, Maria Sol
Lxr Receptors
Glucose Intolerant
Hypothalamus
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
title_short Alterations of LXRα and LXRβ expression in the hypothalamus of glucose-intolerant rats
title_full Alterations of LXRα and LXRβ expression in the hypothalamus of glucose-intolerant rats
title_fullStr Alterations of LXRα and LXRβ expression in the hypothalamus of glucose-intolerant rats
title_full_unstemmed Alterations of LXRα and LXRβ expression in the hypothalamus of glucose-intolerant rats
title_sort Alterations of LXRα and LXRβ expression in the hypothalamus of glucose-intolerant rats
dc.creator.none.fl_str_mv Kruse, Maria Sol
Rey, Mariana
Vega, Maria Cristina
Coirini, Hector
author Kruse, Maria Sol
author_facet Kruse, Maria Sol
Rey, Mariana
Vega, Maria Cristina
Coirini, Hector
author_role author
author2 Rey, Mariana
Vega, Maria Cristina
Coirini, Hector
author2_role author
author
author
dc.subject.none.fl_str_mv Lxr Receptors
Glucose Intolerant
Hypothalamus
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
topic Lxr Receptors
Glucose Intolerant
Hypothalamus
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
description Liver X receptor (LXR) a and b are nuclear receptors that are crucial for the regulation of carbohydrate and lipid metabolism. Activation of LXRs in the brain facilitates cholesterol clearance and improves cognitive deficits, thus they are considered as promising drug targets to treat diseases such as atherosclerosis and Alzheimer´s disease. Nevertheless, little is known about the function and localization of LXRs in the brain. Here, we studied the expression of LXR in the brains of rats that received free access to 10% (w/v) fructose group (FG) in their beverages or water control drinks (control group (CG)). After 6 weeks rats in the FG presented with hypertriglyceridemia, hyperinsulinemia, and became glucose intolerant, suggesting a progression toward type 2 diabetes. We found that hypothalamic LXR expression was altered in fructose-fed rats. Rats in the FG presented with a decrease in LXRb levels while showing an increase in LXRa expression in the hypothalamus but not in the hippocampus, cerebellum, or neocortex. Moreover, both LXRa and b expression correlated negatively with insulin and triglyceride levels. Interestingly, LXRb showed a negative correlation with the area under the curve during the glucose tolerance test in the CG and a positive correlation in the FG. Immunocytochemistry revealed that the paraventricular and ventromedial nuclei express mainly LXRa whereas the arcuate nucleus expresses LXRb. Both LXR immunosignals were found in the median preoptic area. This is the first study showing a relationship between glucose and lipid homeostasis and the expression of LXRs in the hypothalamus, suggesting that LXRs may trigger neurochemical and neurophysiological responses for the control of food intake and energy expenditure through these receptors.
publishDate 2012
dc.date.none.fl_str_mv 2012-10
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/22184
Kruse, Maria Sol; Rey, Mariana; Vega, Maria Cristina; Coirini, Hector; Alterations of LXRα and LXRβ expression in the hypothalamus of glucose-intolerant rats; BioScientifica; Journal of Endocrinology; 215; 1; 10-2012; 51-58
0022-0795
1479-6805
CONICET Digital
CONICET
url http://hdl.handle.net/11336/22184
identifier_str_mv Kruse, Maria Sol; Rey, Mariana; Vega, Maria Cristina; Coirini, Hector; Alterations of LXRα and LXRβ expression in the hypothalamus of glucose-intolerant rats; BioScientifica; Journal of Endocrinology; 215; 1; 10-2012; 51-58
0022-0795
1479-6805
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://joe.endocrinology-journals.org/content/215/1/51.long
info:eu-repo/semantics/altIdentifier/doi/ 10.1530/JOE-12-0088
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv BioScientifica
publisher.none.fl_str_mv BioScientifica
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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spelling Alterations of LXRα and LXRβ expression in the hypothalamus of glucose-intolerant ratsKruse, Maria SolRey, MarianaVega, Maria CristinaCoirini, HectorLxr ReceptorsGlucose IntolerantHypothalamushttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Liver X receptor (LXR) a and b are nuclear receptors that are crucial for the regulation of carbohydrate and lipid metabolism. Activation of LXRs in the brain facilitates cholesterol clearance and improves cognitive deficits, thus they are considered as promising drug targets to treat diseases such as atherosclerosis and Alzheimer´s disease. Nevertheless, little is known about the function and localization of LXRs in the brain. Here, we studied the expression of LXR in the brains of rats that received free access to 10% (w/v) fructose group (FG) in their beverages or water control drinks (control group (CG)). After 6 weeks rats in the FG presented with hypertriglyceridemia, hyperinsulinemia, and became glucose intolerant, suggesting a progression toward type 2 diabetes. We found that hypothalamic LXR expression was altered in fructose-fed rats. Rats in the FG presented with a decrease in LXRb levels while showing an increase in LXRa expression in the hypothalamus but not in the hippocampus, cerebellum, or neocortex. Moreover, both LXRa and b expression correlated negatively with insulin and triglyceride levels. Interestingly, LXRb showed a negative correlation with the area under the curve during the glucose tolerance test in the CG and a positive correlation in the FG. Immunocytochemistry revealed that the paraventricular and ventromedial nuclei express mainly LXRa whereas the arcuate nucleus expresses LXRb. Both LXR immunosignals were found in the median preoptic area. This is the first study showing a relationship between glucose and lipid homeostasis and the expression of LXRs in the hypothalamus, suggesting that LXRs may trigger neurochemical and neurophysiological responses for the control of food intake and energy expenditure through these receptors.Fil: Kruse, Maria Sol. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Rey, Mariana. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Vega, Maria Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Coirini, Hector. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquímica Humana; Argentina. Universidad Catolica de Cuyo - Sede San Juan; ArgentinaBioScientifica2012-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/22184Kruse, Maria Sol; Rey, Mariana; Vega, Maria Cristina; Coirini, Hector; Alterations of LXRα and LXRβ expression in the hypothalamus of glucose-intolerant rats; BioScientifica; Journal of Endocrinology; 215; 1; 10-2012; 51-580022-07951479-6805CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://joe.endocrinology-journals.org/content/215/1/51.longinfo:eu-repo/semantics/altIdentifier/doi/ 10.1530/JOE-12-0088info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2024-05-08T14:03:43Zoai:ri.conicet.gov.ar:11336/22184instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982024-05-08 14:03:43.229CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
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