FTIR an d Raman analysis of L - cysteine ethyl ester.HCl interaction with dipalmitoylphosphatidylcholine in anhydrous and hydrated states

Interactions of L-cysteine ethyl ester hydrochloride (CE), a bioactive cysteine derivative, with dipalmitoylphosphatidylcholine (DPPC) were investigated. To gain a deeper insight into analyzing L-cysteine ethyl ester HCl interaction with liposomes of DPPC in anhydrous and hydrated states, we perform...

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Detalles Bibliográficos
Autores: Arias, Juan Marcelo, Tuttolomondo, María Eugenia, Díaz, Sonia Beatriz, Ben Altabef, Aída
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2015
País:Argentina
Institución:Consejo Nacional de Investigaciones Científicas y Técnicas
Repositorio:CONICET Digital (CONICET)
Idioma:inglés
OAI Identifier:oai:ri.conicet.gov.ar:11336/77843
Acceso en línea:http://hdl.handle.net/11336/77843
Access Level:acceso abierto
Palabra clave:Raman
Ftir
Dppc Bilayers
Phospholipid Hydrations
https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
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repository_id_str
spelling FTIR an d Raman analysis of L - cysteine ethyl ester.HCl interaction with dipalmitoylphosphatidylcholine in anhydrous and hydrated statesArias, Juan MarceloTuttolomondo, María EugeniaDíaz, Sonia BeatrizBen Altabef, AídaRamanFtirDppc BilayersPhospholipid Hydrationshttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1Interactions of L-cysteine ethyl ester hydrochloride (CE), a bioactive cysteine derivative, with dipalmitoylphosphatidylcholine (DPPC) were investigated. To gain a deeper insight into analyzing L-cysteine ethyl ester HCl interaction with liposomes of DPPC in anhydrous and hydrated states, we performed experimental studies by infrared (Fourier transform infrared spectroscopy) and Raman spectroscopies. The results revealed that the interaction of CE with the phospholipid head groups was the same in absence or presence of water. In both states, the wavenumber of the PO2 group and C?N bond of the choline group decreased. This behavior can be ascribed to the replacement of hydration water and binding to the phosphate group. In the Raman spectrum results for the anhydrous and gel states, the S?H stretching band of the CE shifted to lower frequencies with a decrease in its force constant. Biologically active lipophilicmolecules such as CE should be studied in terms of their interaction with lipid bilayers prior to the development of advanced lipid carrier systems such as liposomes. The results of these studies provide information onmembrane integrity and physicochemical properties that are essential for the rational design of lipidic drug delivery systems.Fil: Arias, Juan Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto de Química del Noroeste. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Química del Noroeste; ArgentinaFil: Tuttolomondo, María Eugenia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto de Química del Noroeste. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Química del Noroeste; ArgentinaFil: Díaz, Sonia Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto de Química del Noroeste. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Química del Noroeste; ArgentinaFil: Ben Altabef, Aída. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto de Química del Noroeste. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Química del Noroeste; ArgentinaWiley2015-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/77843Arias, Juan Marcelo; Tuttolomondo, María Eugenia; Díaz, Sonia Beatriz; Ben Altabef, Aída; FTIR an d Raman analysis of L - cysteine ethyl ester.HCl interaction with dipalmitoylphosphatidylcholine in anhydrous and hydrated states; Wiley; J. Raman Spectroscopy; 46; 4; 3-2015; 369-3761097-4555CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1002/jrs.4659info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1002/jrs.4659info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2024-05-08T13:43:20Zoai:ri.conicet.gov.ar:11336/77843instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982024-05-08 13:43:20.532CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv FTIR an d Raman analysis of L - cysteine ethyl ester.HCl interaction with dipalmitoylphosphatidylcholine in anhydrous and hydrated states
title FTIR an d Raman analysis of L - cysteine ethyl ester.HCl interaction with dipalmitoylphosphatidylcholine in anhydrous and hydrated states
spellingShingle FTIR an d Raman analysis of L - cysteine ethyl ester.HCl interaction with dipalmitoylphosphatidylcholine in anhydrous and hydrated states
Arias, Juan Marcelo
Raman
Ftir
Dppc Bilayers
Phospholipid Hydrations
https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
title_short FTIR an d Raman analysis of L - cysteine ethyl ester.HCl interaction with dipalmitoylphosphatidylcholine in anhydrous and hydrated states
title_full FTIR an d Raman analysis of L - cysteine ethyl ester.HCl interaction with dipalmitoylphosphatidylcholine in anhydrous and hydrated states
title_fullStr FTIR an d Raman analysis of L - cysteine ethyl ester.HCl interaction with dipalmitoylphosphatidylcholine in anhydrous and hydrated states
title_full_unstemmed FTIR an d Raman analysis of L - cysteine ethyl ester.HCl interaction with dipalmitoylphosphatidylcholine in anhydrous and hydrated states
title_sort FTIR an d Raman analysis of L - cysteine ethyl ester.HCl interaction with dipalmitoylphosphatidylcholine in anhydrous and hydrated states
dc.creator.none.fl_str_mv Arias, Juan Marcelo
Tuttolomondo, María Eugenia
Díaz, Sonia Beatriz
Ben Altabef, Aída
author Arias, Juan Marcelo
author_facet Arias, Juan Marcelo
Tuttolomondo, María Eugenia
Díaz, Sonia Beatriz
Ben Altabef, Aída
author_role author
author2 Tuttolomondo, María Eugenia
Díaz, Sonia Beatriz
Ben Altabef, Aída
author2_role author
author
author
dc.subject.none.fl_str_mv Raman
Ftir
Dppc Bilayers
Phospholipid Hydrations
https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
topic Raman
Ftir
Dppc Bilayers
Phospholipid Hydrations
https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
description Interactions of L-cysteine ethyl ester hydrochloride (CE), a bioactive cysteine derivative, with dipalmitoylphosphatidylcholine (DPPC) were investigated. To gain a deeper insight into analyzing L-cysteine ethyl ester HCl interaction with liposomes of DPPC in anhydrous and hydrated states, we performed experimental studies by infrared (Fourier transform infrared spectroscopy) and Raman spectroscopies. The results revealed that the interaction of CE with the phospholipid head groups was the same in absence or presence of water. In both states, the wavenumber of the PO2 group and C?N bond of the choline group decreased. This behavior can be ascribed to the replacement of hydration water and binding to the phosphate group. In the Raman spectrum results for the anhydrous and gel states, the S?H stretching band of the CE shifted to lower frequencies with a decrease in its force constant. Biologically active lipophilicmolecules such as CE should be studied in terms of their interaction with lipid bilayers prior to the development of advanced lipid carrier systems such as liposomes. The results of these studies provide information onmembrane integrity and physicochemical properties that are essential for the rational design of lipidic drug delivery systems.
publishDate 2015
dc.date.none.fl_str_mv 2015-03
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/77843
Arias, Juan Marcelo; Tuttolomondo, María Eugenia; Díaz, Sonia Beatriz; Ben Altabef, Aída; FTIR an d Raman analysis of L - cysteine ethyl ester.HCl interaction with dipalmitoylphosphatidylcholine in anhydrous and hydrated states; Wiley; J. Raman Spectroscopy; 46; 4; 3-2015; 369-376
1097-4555
CONICET Digital
CONICET
url http://hdl.handle.net/11336/77843
identifier_str_mv Arias, Juan Marcelo; Tuttolomondo, María Eugenia; Díaz, Sonia Beatriz; Ben Altabef, Aída; FTIR an d Raman analysis of L - cysteine ethyl ester.HCl interaction with dipalmitoylphosphatidylcholine in anhydrous and hydrated states; Wiley; J. Raman Spectroscopy; 46; 4; 3-2015; 369-376
1097-4555
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1002/jrs.4659
info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1002/jrs.4659
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 15,812429

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