Photodynamic Antibacterial Chemotherapy (PACT) Against Staphylococcus aureus and Escherichia coli Using Gold Nanoparticles and LED's Irradiation
Gold nanoparticles synthesized through sodium citrate (A-AuNPs) and sodium borohydrade (B-AuNPs) reduction of Au3+ and a photochemically initiated method (C-AuNPs) were tested for possible application in Photodynamic Antibacterial Chemotherapy. None of them presented inhibitory activity against bact...
| Autores: | , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2014 |
| País: | Argentina |
| Institución: | Consejo Nacional de Investigaciones Científicas y Técnicas |
| Repositorio: | CONICET Digital (CONICET) |
| Idioma: | inglés |
| OAI Identifier: | oai:ri.conicet.gov.ar:11336/22553 |
| Acceso en línea: | http://hdl.handle.net/11336/22553 |
| Access Level: | acceso abierto |
| Palabra clave: | Gold Nanoparticles Staphylococcus Aureus Escherichia Coli Photodynamic Antibacterial Chemoterapy https://purl.org/becyt/ford/2.10 https://purl.org/becyt/ford/2 |
| Sumario: | Gold nanoparticles synthesized through sodium citrate (A-AuNPs) and sodium borohydrade (B-AuNPs) reduction of Au3+ and a photochemically initiated method (C-AuNPs) were tested for possible application in Photodynamic Antibacterial Chemotherapy. None of them presented inhibitory activity against bacterial suspensions in dark conditions using the cylinders inhibition method; however, a total inhibition of Staphylococcus aureus ATCC 29213 and an extended-spectrum beta-lactamases-producing Escherichia coli ATCC 25922 growth were observed when incubated with 2 mM B-AuNPs and irradiated with LEDs at 525 nm for 12 h. Characterization of the interaction between S.aureus and B-AuNPs was demonstrated through an optimized procedure for TEM. These results probe that B-AuNPs have a good potential as photosensitizers for PACT. |
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