A change of view: Homologous recombination at single-molecule resolution

Genetic recombination occurs in all organisms and is vital for genome stability. Indeed, in humans, aberrant recombination can lead to diseases such as cancer. Our understanding of homologous recombination is built upon more than a century of scientific inquiry, but achieving a more complete picture...

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Detalles Bibliográficos
Autores: Kaniecki, Kyle, de Tullio, Luisina, Greene, Eric C.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2018
País:Argentina
Institución:Consejo Nacional de Investigaciones Científicas y Técnicas
Repositorio:CONICET Digital (CONICET)
Idioma:inglés
OAI Identifier:oai:ri.conicet.gov.ar:11336/95815
Acceso en línea:http://hdl.handle.net/11336/95815
Access Level:acceso abierto
Palabra clave:SINGLE MOLECULE
HOMOLOGOUS RECOMBINATION
FLUORESCENCE MICROSCOPY
https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
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spelling A change of view: Homologous recombination at single-molecule resolutionKaniecki, Kylede Tullio, LuisinaGreene, Eric C.SINGLE MOLECULEHOMOLOGOUS RECOMBINATIONFLUORESCENCE MICROSCOPYhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Genetic recombination occurs in all organisms and is vital for genome stability. Indeed, in humans, aberrant recombination can lead to diseases such as cancer. Our understanding of homologous recombination is built upon more than a century of scientific inquiry, but achieving a more complete picture using ensemble biochemical and genetic approaches is hampered by population heterogeneity and transient recombination intermediates. Recent advances in single-molecule and super-resolution microscopy methods help to overcome these limitations and have led to new and refined insights into recombination mechanisms, including a detailed understanding of DNA helicase function and synaptonemal complex structure. The ability to view cellular processes at single-molecule resolution promises to transform our understanding of recombination and related processes.Fil: Kaniecki, Kyle. Columbia University; Estados UnidosFil: de Tullio, Luisina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Centro de Investigaciones en Química Biológica de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Centro de Investigaciones en Química Biológica de Córdoba; ArgentinaFil: Greene, Eric C.. Columbia University; Estados UnidosNature Publishing Group2018-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/95815Kaniecki, Kyle; de Tullio, Luisina; Greene, Eric C.; A change of view: Homologous recombination at single-molecule resolution; Nature Publishing Group; Nature Reviews Genetics; 19; 4; 4-2018; 191-2071471-0056CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5866458/info:eu-repo/semantics/altIdentifier/doi/10.1038/nrg.2017.92info:eu-repo/semantics/altIdentifier/url/https://www.nature.com/articles/nrg.2017.92info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2024-05-08T13:57:26Zoai:ri.conicet.gov.ar:11336/95815instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982024-05-08 13:57:26.729CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv A change of view: Homologous recombination at single-molecule resolution
title A change of view: Homologous recombination at single-molecule resolution
spellingShingle A change of view: Homologous recombination at single-molecule resolution
Kaniecki, Kyle
SINGLE MOLECULE
HOMOLOGOUS RECOMBINATION
FLUORESCENCE MICROSCOPY
https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
title_short A change of view: Homologous recombination at single-molecule resolution
title_full A change of view: Homologous recombination at single-molecule resolution
title_fullStr A change of view: Homologous recombination at single-molecule resolution
title_full_unstemmed A change of view: Homologous recombination at single-molecule resolution
title_sort A change of view: Homologous recombination at single-molecule resolution
dc.creator.none.fl_str_mv Kaniecki, Kyle
de Tullio, Luisina
Greene, Eric C.
author Kaniecki, Kyle
author_facet Kaniecki, Kyle
de Tullio, Luisina
Greene, Eric C.
author_role author
author2 de Tullio, Luisina
Greene, Eric C.
author2_role author
author
dc.subject.none.fl_str_mv SINGLE MOLECULE
HOMOLOGOUS RECOMBINATION
FLUORESCENCE MICROSCOPY
https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
topic SINGLE MOLECULE
HOMOLOGOUS RECOMBINATION
FLUORESCENCE MICROSCOPY
https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
description Genetic recombination occurs in all organisms and is vital for genome stability. Indeed, in humans, aberrant recombination can lead to diseases such as cancer. Our understanding of homologous recombination is built upon more than a century of scientific inquiry, but achieving a more complete picture using ensemble biochemical and genetic approaches is hampered by population heterogeneity and transient recombination intermediates. Recent advances in single-molecule and super-resolution microscopy methods help to overcome these limitations and have led to new and refined insights into recombination mechanisms, including a detailed understanding of DNA helicase function and synaptonemal complex structure. The ability to view cellular processes at single-molecule resolution promises to transform our understanding of recombination and related processes.
publishDate 2018
dc.date.none.fl_str_mv 2018-04
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/95815
Kaniecki, Kyle; de Tullio, Luisina; Greene, Eric C.; A change of view: Homologous recombination at single-molecule resolution; Nature Publishing Group; Nature Reviews Genetics; 19; 4; 4-2018; 191-207
1471-0056
CONICET Digital
CONICET
url http://hdl.handle.net/11336/95815
identifier_str_mv Kaniecki, Kyle; de Tullio, Luisina; Greene, Eric C.; A change of view: Homologous recombination at single-molecule resolution; Nature Publishing Group; Nature Reviews Genetics; 19; 4; 4-2018; 191-207
1471-0056
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5866458/
info:eu-repo/semantics/altIdentifier/doi/10.1038/nrg.2017.92
info:eu-repo/semantics/altIdentifier/url/https://www.nature.com/articles/nrg.2017.92
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Nature Publishing Group
publisher.none.fl_str_mv Nature Publishing Group
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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