Thioredoxin and glutaredoxin system proteins-immunolocalization in the rat central nervous system

Background: The oxidoreductases of the thioredoxin (Trx) family of proteins play a major role in the cellularresponse to oxidative stress. Redox imbalance is a major feature of brain damage. For instance, neuronaldamage and glial reaction induced by a hypoxic–ischemic episode is highly related to gl...

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Autores: Aon Bertolino, Maria Laura, Romero, Juan Ignacio, Galeano, Pablo, Holubiec, Mariana Ines, Badorrey, Maria Sol, Saraceno, Gustavo Ezequiel, Hanschmann, Eva Maria, Lillig, Christopher Horst, Capani, Francisco
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2011
País:Argentina
Institución:Consejo Nacional de Investigaciones Científicas y Técnicas
Repositorio:CONICET Digital (CONICET)
Idioma:inglés
OAI Identifier:oai:ri.conicet.gov.ar:11336/198424
Acceso en línea:http://hdl.handle.net/11336/198424
Access Level:acceso abierto
Palabra clave:BRAIN
CNS
GLUTAREDOXIN
GLUTATHIONE
PEROXIREDOXIN
THIOREDOXIN
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
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oai_identifier_str oai:ri.conicet.gov.ar:11336/198424
network_acronym_str AR
network_name_str Argentina
repository_id_str
dc.title.none.fl_str_mv Thioredoxin and glutaredoxin system proteins-immunolocalization in the rat central nervous system
title Thioredoxin and glutaredoxin system proteins-immunolocalization in the rat central nervous system
spellingShingle Thioredoxin and glutaredoxin system proteins-immunolocalization in the rat central nervous system
Aon Bertolino, Maria Laura
BRAIN
CNS
GLUTAREDOXIN
GLUTATHIONE
PEROXIREDOXIN
THIOREDOXIN
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
title_short Thioredoxin and glutaredoxin system proteins-immunolocalization in the rat central nervous system
title_full Thioredoxin and glutaredoxin system proteins-immunolocalization in the rat central nervous system
title_fullStr Thioredoxin and glutaredoxin system proteins-immunolocalization in the rat central nervous system
title_full_unstemmed Thioredoxin and glutaredoxin system proteins-immunolocalization in the rat central nervous system
title_sort Thioredoxin and glutaredoxin system proteins-immunolocalization in the rat central nervous system
dc.creator.none.fl_str_mv Aon Bertolino, Maria Laura
Romero, Juan Ignacio
Galeano, Pablo
Holubiec, Mariana Ines
Badorrey, Maria Sol
Saraceno, Gustavo Ezequiel
Hanschmann, Eva Maria
Lillig, Christopher Horst
Capani, Francisco
author Aon Bertolino, Maria Laura
author_facet Aon Bertolino, Maria Laura
Romero, Juan Ignacio
Galeano, Pablo
Holubiec, Mariana Ines
Badorrey, Maria Sol
Saraceno, Gustavo Ezequiel
Hanschmann, Eva Maria
Lillig, Christopher Horst
Capani, Francisco
author_role author
author2 Romero, Juan Ignacio
Galeano, Pablo
Holubiec, Mariana Ines
Badorrey, Maria Sol
Saraceno, Gustavo Ezequiel
Hanschmann, Eva Maria
Lillig, Christopher Horst
Capani, Francisco
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv BRAIN
CNS
GLUTAREDOXIN
GLUTATHIONE
PEROXIREDOXIN
THIOREDOXIN
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
topic BRAIN
CNS
GLUTAREDOXIN
GLUTATHIONE
PEROXIREDOXIN
THIOREDOXIN
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
description Background: The oxidoreductases of the thioredoxin (Trx) family of proteins play a major role in the cellularresponse to oxidative stress. Redox imbalance is a major feature of brain damage. For instance, neuronaldamage and glial reaction induced by a hypoxic–ischemic episode is highly related to glutamateexcitotoxicity, oxidative stress and mitochondrial dysfunction. Most animal models of hypoxia–ischemiain the central nervous system (CNS) use rats to study the mechanisms involved in neuronal cell death,however, no comprehensive study on the localization of the redox proteins in the rat CNS was available.Methods: The aim of this work was to study the distribution of the following proteins of the thioredoxin andglutathione/glutaredoxin (Grx) systems in the rat CNS by immunohistochemistry: Trx1, Trx2, TrxR1, TrxR2,Txnip, Grx1, Grx2, Grx3, Grx5, and ã-GCS, peroxiredoxin 1 (Prx1), Prx2, Prx3, Prx4, Prx5, and Prx6. We havefocused on areas most sensitive to a hypoxia–ischemic insult: Cerebellum, striatum, hippocampus, spinalcord, substantia nigra, cortex and retina.Results and conclusions: Previous studies implied that these redox proteins may be distributed in most celltypes and regions of the CNS. Here, we have observed several remarkable differences in both abundance and regional distribution that point to a complex interplay and crosstalk between the proteins of this family.General significance: We think that these data might be helpful to reveal new insights into the role of thiol redox pathways in the pathogenesis of hypoxia–ischemia insults and other disorder   of the CNS. This article is part of a Special Issue entitled Human and Murine Redox Protein Atlases.
publishDate 2011
dc.date.none.fl_str_mv 2011-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/198424
Aon Bertolino, Maria Laura; Romero, Juan Ignacio; Galeano, Pablo; Holubiec, Mariana Ines; Badorrey, Maria Sol; et al.; Thioredoxin and glutaredoxin system proteins-immunolocalization in the rat central nervous system; Elsevier Science; Biochimica et Biophysica Acta - General Subjects; 1810; 1; 1-2011; 93-110
0006-3002
0304-4165
CONICET Digital
CONICET
url http://hdl.handle.net/11336/198424
identifier_str_mv Aon Bertolino, Maria Laura; Romero, Juan Ignacio; Galeano, Pablo; Holubiec, Mariana Ines; Badorrey, Maria Sol; et al.; Thioredoxin and glutaredoxin system proteins-immunolocalization in the rat central nervous system; Elsevier Science; Biochimica et Biophysica Acta - General Subjects; 1810; 1; 1-2011; 93-110
0006-3002
0304-4165
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0304416510001704
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.bbagen.2010.06.011
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science
publisher.none.fl_str_mv Elsevier Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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spelling Thioredoxin and glutaredoxin system proteins-immunolocalization in the rat central nervous systemAon Bertolino, Maria LauraRomero, Juan IgnacioGaleano, PabloHolubiec, Mariana InesBadorrey, Maria SolSaraceno, Gustavo EzequielHanschmann, Eva MariaLillig, Christopher HorstCapani, FranciscoBRAINCNSGLUTAREDOXINGLUTATHIONEPEROXIREDOXINTHIOREDOXINhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Background: The oxidoreductases of the thioredoxin (Trx) family of proteins play a major role in the cellularresponse to oxidative stress. Redox imbalance is a major feature of brain damage. For instance, neuronaldamage and glial reaction induced by a hypoxic–ischemic episode is highly related to glutamateexcitotoxicity, oxidative stress and mitochondrial dysfunction. Most animal models of hypoxia–ischemiain the central nervous system (CNS) use rats to study the mechanisms involved in neuronal cell death,however, no comprehensive study on the localization of the redox proteins in the rat CNS was available.Methods: The aim of this work was to study the distribution of the following proteins of the thioredoxin andglutathione/glutaredoxin (Grx) systems in the rat CNS by immunohistochemistry: Trx1, Trx2, TrxR1, TrxR2,Txnip, Grx1, Grx2, Grx3, Grx5, and ã-GCS, peroxiredoxin 1 (Prx1), Prx2, Prx3, Prx4, Prx5, and Prx6. We havefocused on areas most sensitive to a hypoxia–ischemic insult: Cerebellum, striatum, hippocampus, spinalcord, substantia nigra, cortex and retina.Results and conclusions: Previous studies implied that these redox proteins may be distributed in most celltypes and regions of the CNS. Here, we have observed several remarkable differences in both abundance and regional distribution that point to a complex interplay and crosstalk between the proteins of this family.General significance: We think that these data might be helpful to reveal new insights into the role of thiol redox pathways in the pathogenesis of hypoxia–ischemia insults and other disorder   of the CNS. This article is part of a Special Issue entitled Human and Murine Redox Protein Atlases.Fil: Aon Bertolino, Maria Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; ArgentinaFil: Romero, Juan Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; ArgentinaFil: Galeano, Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; ArgentinaFil: Holubiec, Mariana Ines. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; ArgentinaFil: Badorrey, Maria Sol. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; ArgentinaFil: Saraceno, Gustavo Ezequiel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; ArgentinaFil: Hanschmann, Eva Maria. Phillipps-Universität Marburg; AlemaniaFil: Lillig, Christopher Horst. Phillipps-Universität Marburg; AlemaniaFil: Capani, Francisco. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; ArgentinaElsevier Science2011-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/198424Aon Bertolino, Maria Laura; Romero, Juan Ignacio; Galeano, Pablo; Holubiec, Mariana Ines; Badorrey, Maria Sol; et al.; Thioredoxin and glutaredoxin system proteins-immunolocalization in the rat central nervous system; Elsevier Science; Biochimica et Biophysica Acta - General Subjects; 1810; 1; 1-2011; 93-1100006-30020304-4165CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0304416510001704info:eu-repo/semantics/altIdentifier/doi/10.1016/j.bbagen.2010.06.011info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2024-05-08T14:23:29Zoai:ri.conicet.gov.ar:11336/198424instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982024-05-08 14:23:29.803CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
score 15,81155

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