Persistent SARS-Cov-2 Infection in an Immunocompromised Host: Role of the Cellular Immune Response

We present a patient with B-cell depletion and persistence of positive SARS-CoV-2 RT-PCR along 19 weeks despite having received treatment with corticosteroids, Convalescent Plasma (CP) and remdesivir. Direct genome sequences were obtained with a pattern of substitutions characteristic of the B.1.1.7...

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Detalhes bibliográficos
Autores: Duarte, Andrea Mariela, Cruces, Leonel Hernán, Nabaes Jodar, Mercedes Soledad, Goya, Stephanie, Monzani, María Cecilia, Herrera, Mauro, Mazzitelli, Ignacio Gabriel, Turk, Gabriela Julia Ana, Guevara, D., Viegas, Mariana, Quiroga, María Florencia, Laufer, Natalia Lorna, Cuesta, María Celia
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:Argentina
Recursos:Consejo Nacional de Investigaciones Científicas y Técnicas
Repositorio:CONICET Digital (CONICET)
Idioma:inglés
OAI Identifier:oai:ri.conicet.gov.ar:11336/225574
Acesso em linha:http://hdl.handle.net/11336/225574
Access Level:acceso abierto
Palavra-chave:SARS COV-2
Variants
Vaccine
sequence
COVID-19
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
Descrição
Resumo:We present a patient with B-cell depletion and persistence of positive SARS-CoV-2 RT-PCR along 19 weeks despite having received treatment with corticosteroids, Convalescent Plasma (CP) and remdesivir. Direct genome sequences were obtained with a pattern of substitutions characteristic of the B.1.1.7 (alpha) lineage and the presence of mutations during its viral persistence. Although specific humoral response was not detected, there was evidence of a specific cellular response that was enhanced after the first dose of the vaccine.

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