Sequestration of 9-hydroxystearic acid in fahfa (fatty acid esters of hydroxy fatty acids) as a protective mechanism for colon carcinoma cells to avoid apoptotic cell death

Fil: Rodríguez, Juan Pablo. Universidad Nacional del Nordeste. Facultad de Medicina; Argentina.

Detalhes bibliográficos
Autores: Rodríguez, Juan Pablo, Guijas, Carlos, Astudillo del Valle, Alma María, Rubio, Julio Miguel, Balboa, María Ángeles, Balsinde, Jesús
Tipo de documento: artigo
Estado:Versão publicada
Data de publicação:2019
País:Argentina
Recursos:Universidad Nacional del Nordeste
Repositório:Repositorio Institucional de la Universidad Nacional del Nordeste (UNNE)
Idioma:inglês
OAI Identifier:oai:repositorio.unne.edu.ar:123456789/28103
Acesso em linha:http://repositorio.unne.edu.ar/handle/123456789/28103
Access Level:Acceso aberto
Palavra-chave:Colorectal cancer
Hydroxystearic acid
Fatty acid esters of hydroxy fatty
Fatty acid esters of hydroxy fatty acids
Apoptosis
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repository_id_str
dc.title.none.fl_str_mv Sequestration of 9-hydroxystearic acid in fahfa (fatty acid esters of hydroxy fatty acids) as a protective mechanism for colon carcinoma cells to avoid apoptotic cell death
title Sequestration of 9-hydroxystearic acid in fahfa (fatty acid esters of hydroxy fatty acids) as a protective mechanism for colon carcinoma cells to avoid apoptotic cell death
spellingShingle Sequestration of 9-hydroxystearic acid in fahfa (fatty acid esters of hydroxy fatty acids) as a protective mechanism for colon carcinoma cells to avoid apoptotic cell death
Rodríguez, Juan Pablo
Colorectal cancer
Hydroxystearic acid
Fatty acid esters of hydroxy fatty
Fatty acid esters of hydroxy fatty acids
Apoptosis
title_short Sequestration of 9-hydroxystearic acid in fahfa (fatty acid esters of hydroxy fatty acids) as a protective mechanism for colon carcinoma cells to avoid apoptotic cell death
title_full Sequestration of 9-hydroxystearic acid in fahfa (fatty acid esters of hydroxy fatty acids) as a protective mechanism for colon carcinoma cells to avoid apoptotic cell death
title_fullStr Sequestration of 9-hydroxystearic acid in fahfa (fatty acid esters of hydroxy fatty acids) as a protective mechanism for colon carcinoma cells to avoid apoptotic cell death
title_full_unstemmed Sequestration of 9-hydroxystearic acid in fahfa (fatty acid esters of hydroxy fatty acids) as a protective mechanism for colon carcinoma cells to avoid apoptotic cell death
title_sort Sequestration of 9-hydroxystearic acid in fahfa (fatty acid esters of hydroxy fatty acids) as a protective mechanism for colon carcinoma cells to avoid apoptotic cell death
dc.creator.none.fl_str_mv Rodríguez, Juan Pablo
Guijas, Carlos
Astudillo del Valle, Alma María
Rubio, Julio Miguel
Balboa, María Ángeles
Balsinde, Jesús
author Rodríguez, Juan Pablo
author_facet Rodríguez, Juan Pablo
Guijas, Carlos
Astudillo del Valle, Alma María
Rubio, Julio Miguel
Balboa, María Ángeles
Balsinde, Jesús
author_role author
author2 Guijas, Carlos
Astudillo del Valle, Alma María
Rubio, Julio Miguel
Balboa, María Ángeles
Balsinde, Jesús
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Colorectal cancer
Hydroxystearic acid
Fatty acid esters of hydroxy fatty
Fatty acid esters of hydroxy fatty acids
Apoptosis
topic Colorectal cancer
Hydroxystearic acid
Fatty acid esters of hydroxy fatty
Fatty acid esters of hydroxy fatty acids
Apoptosis
description Fil: Rodríguez, Juan Pablo. Universidad Nacional del Nordeste. Facultad de Medicina; Argentina.
publishDate 2019
dc.date.none.fl_str_mv 2019-04-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv Rodríguez, Juan Pablo, et.al., 2019. Sequestration of 9-hydroxystearic acid in fahfa (fatty acid esters of hydroxy fatty acids) as a protective mechanism for colon carcinoma cells to avoid apoptotic cell death. Cancers. Barcelona: Multidisciplinary Digital Publishing Institute, vol. 11, no. 524, p. 1-15. ISSN 2072-6694.
2072-6694
http://repositorio.unne.edu.ar/handle/123456789/28103
identifier_str_mv Rodríguez, Juan Pablo, et.al., 2019. Sequestration of 9-hydroxystearic acid in fahfa (fatty acid esters of hydroxy fatty acids) as a protective mechanism for colon carcinoma cells to avoid apoptotic cell death. Cancers. Barcelona: Multidisciplinary Digital Publishing Institute, vol. 11, no. 524, p. 1-15. ISSN 2072-6694.
2072-6694
url http://repositorio.unne.edu.ar/handle/123456789/28103
dc.language.none.fl_str_mv eng
language eng
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Atribución-NoComercial-SinDerivadas 2.5 Argentina
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Atribución-NoComercial-SinDerivadas 2.5 Argentina
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
dc.source.none.fl_str_mv Cancers, 2019, vol. 11, no. 524, p. 1-15.
reponame:Repositorio Institucional de la Universidad Nacional del Nordeste (UNNE)
instname:Universidad Nacional del Nordeste
instname_str Universidad Nacional del Nordeste
reponame_str Repositorio Institucional de la Universidad Nacional del Nordeste (UNNE)
collection Repositorio Institucional de la Universidad Nacional del Nordeste (UNNE)
repository.name.fl_str_mv Repositorio Institucional de la Universidad Nacional del Nordeste (UNNE) - Universidad Nacional del Nordeste
repository.mail.fl_str_mv ososa@bib.unne.edu.ar;sergio.alegria@unne.edu.ar
_version_ 1799196832568442880
spelling Sequestration of 9-hydroxystearic acid in fahfa (fatty acid esters of hydroxy fatty acids) as a protective mechanism for colon carcinoma cells to avoid apoptotic cell deathRodríguez, Juan PabloGuijas, CarlosAstudillo del Valle, Alma MaríaRubio, Julio MiguelBalboa, María ÁngelesBalsinde, JesúsColorectal cancerHydroxystearic acidFatty acid esters of hydroxy fattyFatty acid esters of hydroxy fatty acidsApoptosisFil: Rodríguez, Juan Pablo. Universidad Nacional del Nordeste. Facultad de Medicina; Argentina.Fil: Rodríguez, Juan Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet Nordeste; Argentina.Fil: Guijas, Carlos. Universidad de Valladolid. Consejo Superior de Investigaciones Científicas. Instituto de Biología y Genética Molecular; España.Fil: Guijas, Carlos. Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas; España.Fil: Astudillo del Valle, Alma María. Universidad de Valladolid. Consejo Superior de Investigaciones Científicas. Instituto de Biología y Genética Molecular; España.Fil: Astudillo del Valle, Alma María. Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas; España.Fil: Rubio, Julio Miguel. Universidad de Valladolid. Consejo Superior de Investigaciones Científicas. Instituto de Biología y Genética Molecular; España.Fil: Rubio, Julio Miguel. Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas; España.Fil: Balboa, María Ángeles. Universidad de Valladolid. Consejo Superior de Investigaciones Científicas. Instituto de Biología y Genética Molecular; España.Fil: Balboa, María Ángeles. Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas; España.Fil: Balsinde, Jesús. Universidad de Valladolid. Consejo Superior de Investigaciones Científicas. Instituto de Biología y Genética Molecular; España.Fil: Balsinde, Jesús. Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas; España.Hydroxy fatty acids are known to cause cell cycle arrest and apoptosis. The best studied of them, 9-hydroxystearic acid (9-HSA), induces apoptosis in cell lines by acting through mechanisms involving different targets. Using mass spectrometry-based lipidomic approaches, we show in this study that 9-HSA levels in human colorectal tumors are diminished when compared with normal adjacent tissue. Since this decrease could be compatible with an escape mechanism of tumors from 9-HAS induced apoptosis, we investigated different features of the utilization of this hydroxyl fatty acid in colon. We show that in colorectal tumors and related cell lines such as HT-29 and HCT-116, 9-HSA is the only hydroxyl fatty acid constituent of branched fatty acid esters of hydroxyl fatty acids (FAHFA), a novel family of lipids with anti-inflammatory properties. Importantly, FAHFA levels in tumors are elevated compared with normal tissue and, unlike 9-HSA, they do not induce apoptosis of colorectal cell lines over a wide range of concentrations. Further, the addition of 9-HSA to colon cancer cell lines augments the synthesis of different FAHFA before the cells commit to apoptosis, suggesting that FAHFA formation may function as a buffer system that sequesters the hydroxyacidinto an inactive form, thereby restricting apoptosis.Multidisciplinary Digital Publishing Institute2019-04-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfRodríguez, Juan Pablo, et.al., 2019. Sequestration of 9-hydroxystearic acid in fahfa (fatty acid esters of hydroxy fatty acids) as a protective mechanism for colon carcinoma cells to avoid apoptotic cell death. Cancers. Barcelona: Multidisciplinary Digital Publishing Institute, vol. 11, no. 524, p. 1-15. ISSN 2072-6694.2072-6694http://repositorio.unne.edu.ar/handle/123456789/28103Cancers, 2019, vol. 11, no. 524, p. 1-15.reponame:Repositorio Institucional de la Universidad Nacional del Nordeste (UNNE)instname:Universidad Nacional del Nordesteenginfo:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-nd/2.5/ar/Atribución-NoComercial-SinDerivadas 2.5 Argentina2024-05-10T11:51:45Zoai:repositorio.unne.edu.ar:123456789/28103instacron:UNNEInstitucionalhttp://repositorio.unne.edu.ar/Universidad públicaNo correspondehttp://repositorio.unne.edu.ar/oaiososa@bib.unne.edu.ar;sergio.alegria@unne.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:48712024-05-10 11:51:45.885Repositorio Institucional de la Universidad Nacional del Nordeste (UNNE) - Universidad Nacional del Nordestefalse
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