Virucidal activity presence in Trichilia glabra leaves
Different immunomodulatory activities present in Trichilia glabra (TG) leaf extracts have already been described. Particularly, chloroform-methanol extracts were responsible for an in-vivo anti-inflammatory effect. The effect of such extracts on the infectivity of enveloped and naked viruses were in...
| Autores: | , , , |
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| Formato: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2004 |
| País: | Argentina |
| Recursos: | Universidad Nacional de Buenos Aires. Facultad de Ciencias Exactas y Naturales |
| Repositorio: | Biblioteca Digital (UBA-FCEN) |
| Idioma: | inglés |
| OAI Identifier: | paperaa:paper_03257541_v36_n3_p136_Cella |
| Acesso em linha: | http://hdl.handle.net/20.500.12110/paper_03257541_v36_n3_p136_Cella |
| Access Level: | acceso abierto |
| Palavra-chave: | Methanolic extracts Trichilia glabra leaves Virucidal activity chloroform methanol plant extract Trichilia glabra extract unclassified drug antiinflammatory activity antiviral activity article controlled study Herpes simplex virus 1 immunomodulation in vivo study medicinal plant nonhuman plant leaf Poliomyelitis virus Trichilia glabra Vesicular stomatitis virus virus infectivity virus titration Animals Antiviral Agents Cercopithecus aethiops Chemical Fractionation Chloroform Herpesvirus 1, Human Meliaceae Methanol Plant Extracts Plant Leaves Poliovirus Vero Cells Vesicular stomatitis-Indiana virus |
| Resumo: | Different immunomodulatory activities present in Trichilia glabra (TG) leaf extracts have already been described. Particularly, chloroform-methanol extracts were responsible for an in-vivo anti-inflammatory effect. The effect of such extracts on the infectivity of enveloped and naked viruses were investigated. Methanolic fraction extracts were active against herpes simplex virus type 1 (HSV-1) and vesicular stomatitis virus (VSV), while no activity against poliovirus type 3 was observed. VSV was slightly more affected than HSV-1: 2.8 log10 reduction in VSV titer against 2.4 log10 reduction in HSV-1 titer when 0.25 mg/ml F2 fraction was tested and a reduction of 2.7 log10 in VSV virus titer and of 1.5 log10 in HSV-1 virus titer was observed when 0.25 mg/ml F3 fraction was tested. Results obtained in this work suggest a potential pharmaceutical use of TG extract components. |
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