NMDA receptors and BDNF are necessary for discrimination of overlapping spatial and non-spatial memories in perirhinal cortex and hippocampus

Successful memory involves not only remembering information over time but also keeping memories distinct and less confusable. Discrimination of overlapping representations has been investigated in the dentate gyrus (DG) of the hippocampus and largely in the perirhinal cortex (Prh). In particular, th...

Descripción completa

Detalles Bibliográficos
Autores: Miranda, Magdalena, Kent, Brianne A., Morici, Juan Facundo, Gallo, Francisco Tomás, Saksida, Lisa M., Bussey, Timothy J., Weisstaub, Noelia V., Bekinschtein, Pedro Alejandro
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2018
País:Argentina
Institución:Consejo Nacional de Investigaciones Científicas y Técnicas
Repositorio:CONICET Digital (CONICET)
Idioma:inglés
OAI Identifier:oai:ri.conicet.gov.ar:11336/99364
Acceso en línea:http://hdl.handle.net/11336/99364
Access Level:acceso abierto
Palabra clave:BDNF
DENTATE GYRUS
NMDA RECEPTORS
OBJECT RECOGNITION
PATTERN SEPARATION
PERIRHINAL CORTEX
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
id AR_23ecb0191ef92adb2c8db3ffb62f17d0
oai_identifier_str oai:ri.conicet.gov.ar:11336/99364
network_acronym_str AR
network_name_str Argentina
repository_id_str
spelling NMDA receptors and BDNF are necessary for discrimination of overlapping spatial and non-spatial memories in perirhinal cortex and hippocampusMiranda, MagdalenaKent, Brianne A.Morici, Juan FacundoGallo, Francisco TomásSaksida, Lisa M.Bussey, Timothy J.Weisstaub, Noelia V.Bekinschtein, Pedro AlejandroBDNFDENTATE GYRUSNMDA RECEPTORSOBJECT RECOGNITIONPATTERN SEPARATIONPERIRHINAL CORTEXhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Successful memory involves not only remembering information over time but also keeping memories distinct and less confusable. Discrimination of overlapping representations has been investigated in the dentate gyrus (DG) of the hippocampus and largely in the perirhinal cortex (Prh). In particular, the DG was shown to be important for discrimination of overlapping spatial memories and Prh was shown to be important for discrimination of overlapping object memories. In the present study, we used both a DG-dependent and a Prh-dependent task and manipulated the load of similarity between either spatial or object stimuli during information encoding. We showed that N-methyl-D-aspartate-type glutamate receptors (NMDAr) and BDNF participate of the same cellular network during consolidation of both overlapping object and spatial memories in the Prh and DG, respectively. This argues in favor of conserved cellular mechanisms across regions despite anatomical differences.Fil: Miranda, Magdalena. Instituto de Neurología Cognitiva; Argentina. Universidad Favaloro; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Kent, Brianne A.. University of British Columbia; CanadáFil: Morici, Juan Facundo. Instituto de Neurología Cognitiva; Argentina. Universidad Favaloro; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Gallo, Francisco Tomás. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Instituto de Neurología Cognitiva; Argentina. Universidad Favaloro; ArgentinaFil: Saksida, Lisa M.. University of Cambridge; Reino Unido. Western University; CanadáFil: Bussey, Timothy J.. University of Cambridge; Reino Unido. Western University; CanadáFil: Weisstaub, Noelia V.. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Favaloro; Argentina. Instituto de Neurología Cognitiva; ArgentinaFil: Bekinschtein, Pedro Alejandro. Instituto de Neurología Cognitiva; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Favaloro; ArgentinaAcademic Press Inc Elsevier Science2018-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/99364Miranda, Magdalena; Kent, Brianne A.; Morici, Juan Facundo; Gallo, Francisco Tomás; Saksida, Lisa M.; et al.; NMDA receptors and BDNF are necessary for discrimination of overlapping spatial and non-spatial memories in perirhinal cortex and hippocampus; Academic Press Inc Elsevier Science; Neurobiology of Learning and Memory; 155; 11-2018; 337-3431074-7427CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S1074742718302132info:eu-repo/semantics/altIdentifier/doi/10.1016/j.nlm.2018.08.019info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2024-05-08T14:23:08Zoai:ri.conicet.gov.ar:11336/99364instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982024-05-08 14:23:08.668CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv NMDA receptors and BDNF are necessary for discrimination of overlapping spatial and non-spatial memories in perirhinal cortex and hippocampus
title NMDA receptors and BDNF are necessary for discrimination of overlapping spatial and non-spatial memories in perirhinal cortex and hippocampus
spellingShingle NMDA receptors and BDNF are necessary for discrimination of overlapping spatial and non-spatial memories in perirhinal cortex and hippocampus
Miranda, Magdalena
BDNF
DENTATE GYRUS
NMDA RECEPTORS
OBJECT RECOGNITION
PATTERN SEPARATION
PERIRHINAL CORTEX
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
title_short NMDA receptors and BDNF are necessary for discrimination of overlapping spatial and non-spatial memories in perirhinal cortex and hippocampus
title_full NMDA receptors and BDNF are necessary for discrimination of overlapping spatial and non-spatial memories in perirhinal cortex and hippocampus
title_fullStr NMDA receptors and BDNF are necessary for discrimination of overlapping spatial and non-spatial memories in perirhinal cortex and hippocampus
title_full_unstemmed NMDA receptors and BDNF are necessary for discrimination of overlapping spatial and non-spatial memories in perirhinal cortex and hippocampus
title_sort NMDA receptors and BDNF are necessary for discrimination of overlapping spatial and non-spatial memories in perirhinal cortex and hippocampus
dc.creator.none.fl_str_mv Miranda, Magdalena
Kent, Brianne A.
Morici, Juan Facundo
Gallo, Francisco Tomás
Saksida, Lisa M.
Bussey, Timothy J.
Weisstaub, Noelia V.
Bekinschtein, Pedro Alejandro
author Miranda, Magdalena
author_facet Miranda, Magdalena
Kent, Brianne A.
Morici, Juan Facundo
Gallo, Francisco Tomás
Saksida, Lisa M.
Bussey, Timothy J.
Weisstaub, Noelia V.
Bekinschtein, Pedro Alejandro
author_role author
author2 Kent, Brianne A.
Morici, Juan Facundo
Gallo, Francisco Tomás
Saksida, Lisa M.
Bussey, Timothy J.
Weisstaub, Noelia V.
Bekinschtein, Pedro Alejandro
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv BDNF
DENTATE GYRUS
NMDA RECEPTORS
OBJECT RECOGNITION
PATTERN SEPARATION
PERIRHINAL CORTEX
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
topic BDNF
DENTATE GYRUS
NMDA RECEPTORS
OBJECT RECOGNITION
PATTERN SEPARATION
PERIRHINAL CORTEX
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
description Successful memory involves not only remembering information over time but also keeping memories distinct and less confusable. Discrimination of overlapping representations has been investigated in the dentate gyrus (DG) of the hippocampus and largely in the perirhinal cortex (Prh). In particular, the DG was shown to be important for discrimination of overlapping spatial memories and Prh was shown to be important for discrimination of overlapping object memories. In the present study, we used both a DG-dependent and a Prh-dependent task and manipulated the load of similarity between either spatial or object stimuli during information encoding. We showed that N-methyl-D-aspartate-type glutamate receptors (NMDAr) and BDNF participate of the same cellular network during consolidation of both overlapping object and spatial memories in the Prh and DG, respectively. This argues in favor of conserved cellular mechanisms across regions despite anatomical differences.
publishDate 2018
dc.date.none.fl_str_mv 2018-11
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/99364
Miranda, Magdalena; Kent, Brianne A.; Morici, Juan Facundo; Gallo, Francisco Tomás; Saksida, Lisa M.; et al.; NMDA receptors and BDNF are necessary for discrimination of overlapping spatial and non-spatial memories in perirhinal cortex and hippocampus; Academic Press Inc Elsevier Science; Neurobiology of Learning and Memory; 155; 11-2018; 337-343
1074-7427
CONICET Digital
CONICET
url http://hdl.handle.net/11336/99364
identifier_str_mv Miranda, Magdalena; Kent, Brianne A.; Morici, Juan Facundo; Gallo, Francisco Tomás; Saksida, Lisa M.; et al.; NMDA receptors and BDNF are necessary for discrimination of overlapping spatial and non-spatial memories in perirhinal cortex and hippocampus; Academic Press Inc Elsevier Science; Neurobiology of Learning and Memory; 155; 11-2018; 337-343
1074-7427
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S1074742718302132
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.nlm.2018.08.019
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Academic Press Inc Elsevier Science
publisher.none.fl_str_mv Academic Press Inc Elsevier Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1799196321472577536
score 15,811543

Similares en LA Referencia