Aquaporins: Another piece in the osmotic puzzle
Osmolarity not only plays a key role in celluar homeostasis but also challenges cell survival. The molecular understanding of osmosis has not yet been completely achieved, and the discovery of aquaporins as molecular entities involved in water transport has caused osmosis to again become a focus of...
| Autores: | , , |
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| Tipo de documento: | artigo |
| Estado: | Versão publicada |
| Data de publicação: | 2012 |
| País: | Argentina |
| Recursos: | Universidad Nacional de Buenos Aires. Facultad de Ciencias Exactas y Naturales |
| Repositório: | Biblioteca Digital (UBA-FCEN) |
| Idioma: | inglês |
| OAI Identifier: | paperaa:paper_00145793_v586_n19_p2991_Alleva |
| Acesso em linha: | http://hdl.handle.net/20.500.12110/paper_00145793_v586_n19_p2991_Alleva |
| Access Level: | Acceso aberto |
| Palavra-chave: | Aquaporin Osmosis Osmotic permeability Phenomenological law Water transport aquaporin bioinformatics biophysics brain edema hydraulic permeability lipid bilayer membrane permeability molecular interaction nonhuman nutrient uptake osmosis plant physiology priority journal protein function protein structure review statistical analysis transport kinetics tumor growth tumor vascularization water transport Animals Aquaporins Biophysical Phenomena Cell Membrane Permeability Computational Biology History, 20th Century History, 21st Century Humans Models, Biological Osmolar Concentration Plant Proteins Water |
| Resumo: | Osmolarity not only plays a key role in celluar homeostasis but also challenges cell survival. The molecular understanding of osmosis has not yet been completely achieved, and the discovery of aquaporins as molecular entities involved in water transport has caused osmosis to again become a focus of research. The main questions that need to be answered are the mechanism underlying the osmotic permeability coefficients and the extent to which aquaporins change our understanding of osmosis. Here, attempts to answer these questions are discussed. Critical aspects of the state of the state of knowledge on osmosis, a topic that has been studied since 19th century, are reviewed and integrated with the available information provided by in vivo, in vitro and in silico approaches. © 2012 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved. |
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