The role of inherited and acquired factors in the development of porphyria cutanea tarda in the Argentinean population
Background: Inherited and environmental factors are implicated in the expression of porphyria cutanea tarda (PCT); the contribution of each factor depends on the population.Inherited and environmental factors are implicated in the expression of porphyria cutanea tarda (PCT); the contribution of ea...
| Autores: | , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2005 |
| País: | Argentina |
| Institución: | Consejo Nacional de Investigaciones Científicas y Técnicas |
| Repositorio: | CONICET Digital (CONICET) |
| Idioma: | inglés |
| OAI Identifier: | oai:ri.conicet.gov.ar:11336/147347 |
| Acceso en línea: | http://hdl.handle.net/11336/147347 |
| Access Level: | acceso abierto |
| Palabra clave: | https://purl.org/becyt/ford/1.4 https://purl.org/becyt/ford/1 |
| Sumario: | Background: Inherited and environmental factors are implicated in the expression of porphyria cutanea tarda (PCT); the contribution of each factor depends on the population.Inherited and environmental factors are implicated in the expression of porphyria cutanea tarda (PCT); the contribution of each factor depends on the population. Objective: To provide a review of PCT cases diagnosed in Argentina over 24 years and evaluate the role of different precipitating factors in its pathogenesis.To provide a review of PCT cases diagnosed in Argentina over 24 years and evaluate the role of different precipitating factors in its pathogenesis. Methods: Plasma and urinary porphyrin levels and erythrocyte uroporphyrinogen decarboxylase (URO-D) activity were determined. Potential precipitating factors were identified in each patient. Additional tests for hepatitis C virus (HCV) and hemochromatosis gene mutations were carried out.Plasma and urinary porphyrin levels and erythrocyte uroporphyrinogen decarboxylase (URO-D) activity were determined. Potential precipitating factors were identified in each patient. Additional tests for hepatitis C virus (HCV) and hemochromatosis gene mutations were carried out. Results: Several factors (mainly alcohol abuse in men and estrogen ingestion in women), alone or combined were identified in our patients. Prevalence of HCV infection was 35.2%. Inherited URO-D deficiency occurs in 25.0% of cases. H63D was the most common hemochromatosis gene mutation. High incidence of PCT associated with HIV infection was found. Conclusions: PCT is multifactorial. Therefore, knowledge of all risk factors in each patient is important for the management of the disease. ( J Am Acad Dermatol 2005;52:417-24.) combined were identified in our patients. Prevalence of HCV infection was 35.2%. Inherited URO-D deficiency occurs in 25.0% of cases. H63D was the most common hemochromatosis gene mutation. High incidence of PCT associated with HIV infection was found. Conclusions: PCT is multifactorial. Therefore, knowledge of all risk factors in each patient is important for the management of the disease. ( J Am Acad Dermatol 2005;52:417-24.) combined were identified in our patients. Prevalence of HCV infection was 35.2%. Inherited URO-D deficiency occurs in 25.0% of cases. H63D was the most common hemochromatosis gene mutation. High incidence of PCT associated with HIV infection was found. Conclusions: PCT is multifactorial. Therefore, knowledge of all risk factors in each patient is important for the management of the disease. ( J Am Acad Dermatol 2005;52:417-24.) combined were identified in our patients. Prevalence of HCV infection was 35.2%. Inherited URO-D deficiency occurs in 25.0% of cases. H63D was the most common hemochromatosis gene mutation. High incidence of PCT associated with HIV infection was found. Conclusions: PCT is multifactorial. Therefore, knowledge of all risk factors in each patient is important for the management of the disease. ( J Am Acad Dermatol 2005;52:417-24.) combined were identified in our patients. Prevalence of HCV infection was 35.2%. Inherited URO-D deficiency occurs in 25.0% of cases. H63D was the most common hemochromatosis gene mutation. High incidence of PCT associated with HIV infection was found. Conclusions: PCT is multifactorial. Therefore, knowledge of all risk factors in each patient is important for the management of the disease. ( J Am Acad Dermatol 2005;52:417-24.) combined were identified in our patients. Prevalence of HCV infection was 35.2%. Inherited URO-D deficiency occurs in 25.0% of cases. H63D was the most common hemochromatosis gene mutation. High incidence of PCT associated with HIV infection was found. Conclusions: PCT is multifactorial. Therefore, knowledge of all risk factors in each patient is important for the management of the disease. ( J Am Acad Dermatol 2005;52:417-24.) combined were identified in our patients. Prevalence of HCV infection was 35.2%. Inherited URO-D deficiency occurs in 25.0% of cases. H63D was the most common hemochromatosis gene mutation. High incidence of PCT associated with HIV infection was found. Conclusions: PCT is multifactorial. Therefore, knowledge of all risk factors in each patient is important for the management of the disease. ( J Am Acad Dermatol 2005;52:417-24.) combined were identified in our patients. Prevalence of HCV infection was 35.2%. Inherited URO-D deficiency occurs in 25.0% of cases. H63D was the most common hemochromatosis gene mutation. High incidence of PCT associated with HIV infection was found. Conclusions: PCT is multifactorial. Therefore, knowledge of all risk factors in each patient is important for the management of the disease. ( J Am Acad Dermatol 2005;52:417-24.) combined were identified in our patients. Prevalence of HCV infection was 35.2%. Inherited URO-D deficiency occurs in 25.0% of cases. H63D was the most common hemochromatosis gene mutation. High incidence of PCT associated with HIV infection was found. Conclusions: PCT is multifactorial. Therefore, knowledge of all risk factors in each patient is important for the management of the disease. ( J Am Acad Dermatol 2005;52:417-24.) Several factors (mainly alcohol abuse in men and estrogen ingestion in women), alone or combined were identified in our patients. Prevalence of HCV infection was 35.2%. Inherited URO-D deficiency occurs in 25.0% of cases. H63D was the most common hemochromatosis gene mutation. High incidence of PCT associated with HIV infection was found. Conclusions: PCT is multifactorial. Therefore, knowledge of all risk factors in each patient is important for the management of the disease. ( J Am Acad Dermatol 2005;52:417-24.)Conclusions: PCT is multifactorial. Therefore, knowledge of all risk factors in each patient is important for the management of the disease. ( J Am Acad Dermatol 2005;52:417-24.) |
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