Discretization of gene expression data revised

Gene expression measurements represent the most important source of biological data used to unveil theinteraction and functionality of genes. In this regard, several data mining and machine learning algorithms havebeen proposed that require, in a number of cases, some kind of data discretization in...

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Detalhes bibliográficos
Autores: Gallo, Cristian Andrés, Cecchini, Rocío Luján, Carballido, Jessica Andrea, Micheletto, Sandra, Ponzoni, Ignacio
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2015
País:Argentina
Recursos:Consejo Nacional de Investigaciones Científicas y Técnicas
Repositorio:CONICET Digital (CONICET)
Idioma:inglés
OAI Identifier:oai:ri.conicet.gov.ar:11336/21610
Acesso em linha:http://hdl.handle.net/11336/21610
Access Level:acceso abierto
Palavra-chave:Data Preprocessing
Data Mining
Gene Expression Data
Discretization
Gene Expressiion Analysis
Machine Learning
https://purl.org/becyt/ford/1.2
https://purl.org/becyt/ford/1
Descrição
Resumo:Gene expression measurements represent the most important source of biological data used to unveil theinteraction and functionality of genes. In this regard, several data mining and machine learning algorithms havebeen proposed that require, in a number of cases, some kind of data discretization in order to perform theinference. Selection of an appropriate discretization process has a major impact on the design and outcome of theinference algorithms, since there are a number of relevant issues that need to be considered. This study presents arevision of the current state of the art discretization techniques, together with the key subjects that need to beconsidered when designing or selecting a discretization approach for gene expression data.