The Simons Genome Diversity Project : 300 genomes from 142 diverse populations.

Here we report the Simons Genome Diversity Project data set: high quality genomes from 300 individuals from 142 diverse populations. These genomes include at least 5.8 million base pairs that are not present in the human reference genome. Our analysis reveals key features of the landscape of human g...

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Author: Bravi, Claudio Marcelo
Format: article
Status:Published version
Publication Date:2016
Country:Argentina
Institution:Universidad Nacional de La Plata
Repository:SEDICI (UNLP)
Language:Spanish
OAI Identifier:oai:sedici.unlp.edu.ar:10915/107824
Online Access:http://sedici.unlp.edu.ar/handle/10915/107824
Access Level:Open access
Keyword:Ciencias Médicas
Simons Genome Diversity Project
Human genome variation
Divergence
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spelling The Simons Genome Diversity Project : 300 genomes from 142 diverse populations.Bravi, Claudio MarceloCiencias MédicasSimons Genome Diversity ProjectHuman genome variationDivergenceHere we report the Simons Genome Diversity Project data set: high quality genomes from 300 individuals from 142 diverse populations. These genomes include at least 5.8 million base pairs that are not present in the human reference genome. Our analysis reveals key features of the landscape of human genome variation, including that the rate of accumulation of mutations has accelerated by about 5% in non-Africans compared to Africans since divergence. We show that the ancestors of some pairs of present-day human populations were substantially separated by 100,000 years ago, well before the archaeologically attested onset of behavioural modernity. We also demonstrate that indigenous Australians, New Guineans and Andamanese do not derive substantial ancestry from an early dispersal of modern humans; instead, their modern human ancestry is consistent with coming from the same source as that of other non-Africans.Facultad de Ciencias Naturales y Museo2016info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttp://sedici.unlp.edu.ar/handle/10915/107824spainfo:eu-repo/semantics/altIdentifier/url/http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC5161557&blobtype=pdfinfo:eu-repo/semantics/altIdentifier/issn/1476-4687info:eu-repo/semantics/altIdentifier/pmid/27654912info:eu-repo/semantics/altIdentifier/doi/10.1038/nature18964info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2024-05-08T13:02:06Zoai:sedici.unlp.edu.ar:10915/107824Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292024-05-08 13:02:06.869SEDICI (UNLP) - Universidad Nacional de La Platafalse
dc.title.none.fl_str_mv The Simons Genome Diversity Project : 300 genomes from 142 diverse populations.
title The Simons Genome Diversity Project : 300 genomes from 142 diverse populations.
spellingShingle The Simons Genome Diversity Project : 300 genomes from 142 diverse populations.
Bravi, Claudio Marcelo
Ciencias Médicas
Simons Genome Diversity Project
Human genome variation
Divergence
title_short The Simons Genome Diversity Project : 300 genomes from 142 diverse populations.
title_full The Simons Genome Diversity Project : 300 genomes from 142 diverse populations.
title_fullStr The Simons Genome Diversity Project : 300 genomes from 142 diverse populations.
title_full_unstemmed The Simons Genome Diversity Project : 300 genomes from 142 diverse populations.
title_sort The Simons Genome Diversity Project : 300 genomes from 142 diverse populations.
dc.creator.none.fl_str_mv Bravi, Claudio Marcelo
author Bravi, Claudio Marcelo
author_facet Bravi, Claudio Marcelo
author_role author
dc.subject.none.fl_str_mv Ciencias Médicas
Simons Genome Diversity Project
Human genome variation
Divergence
topic Ciencias Médicas
Simons Genome Diversity Project
Human genome variation
Divergence
description Here we report the Simons Genome Diversity Project data set: high quality genomes from 300 individuals from 142 diverse populations. These genomes include at least 5.8 million base pairs that are not present in the human reference genome. Our analysis reveals key features of the landscape of human genome variation, including that the rate of accumulation of mutations has accelerated by about 5% in non-Africans compared to Africans since divergence. We show that the ancestors of some pairs of present-day human populations were substantially separated by 100,000 years ago, well before the archaeologically attested onset of behavioural modernity. We also demonstrate that indigenous Australians, New Guineans and Andamanese do not derive substantial ancestry from an early dispersal of modern humans; instead, their modern human ancestry is consistent with coming from the same source as that of other non-Africans.
publishDate 2016
dc.date.none.fl_str_mv 2016
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Articulo
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://sedici.unlp.edu.ar/handle/10915/107824
url http://sedici.unlp.edu.ar/handle/10915/107824
dc.language.none.fl_str_mv spa
language spa
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info:eu-repo/semantics/altIdentifier/issn/1476-4687
info:eu-repo/semantics/altIdentifier/pmid/27654912
info:eu-repo/semantics/altIdentifier/doi/10.1038/nature18964
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
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Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
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rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:SEDICI (UNLP)
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instname_str Universidad Nacional de La Plata
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collection SEDICI (UNLP)
repository.name.fl_str_mv SEDICI (UNLP) - Universidad Nacional de La Plata
repository.mail.fl_str_mv alira@sedici.unlp.edu.ar
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