Nonclassical roles for IFN-γ and IL-10 in a murine model of immunoedition

Aim: To characterize, by means of univariate and multivariate approaches, the T helper (Th)-1 and Th-2 responses during the different phases of tumor immunoediting. Materials & methods: We used a multivariate principal component analysis applied to analyze the joint behavior of serum concentrati...

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Autores: del Giúdice, Antonela, Pagura, Lucas, Capitani, María Celeste, Mainetti, Leandro Ernesto, Scharovsky, Olga Graciela, Di Masso, Ricardo Jose, Rico, Maria Jose, Rozados, Viviana Rosa
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2020
País:Argentina
Institución:Consejo Nacional de Investigaciones Científicas y Técnicas
Repositorio:CONICET Digital (CONICET)
Idioma:inglés
OAI Identifier:oai:ri.conicet.gov.ar:11336/174627
Acceso en línea:http://hdl.handle.net/11336/174627
Access Level:acceso abierto
Palabra clave:CANCER IMMUNOEDITING
MAMMARY ADENOCARCINOMA
MATHEMATICAL MODEL
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
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oai_identifier_str oai:ri.conicet.gov.ar:11336/174627
network_acronym_str AR
network_name_str Argentina
repository_id_str
dc.title.none.fl_str_mv Nonclassical roles for IFN-γ and IL-10 in a murine model of immunoedition
title Nonclassical roles for IFN-γ and IL-10 in a murine model of immunoedition
spellingShingle Nonclassical roles for IFN-γ and IL-10 in a murine model of immunoedition
del Giúdice, Antonela
CANCER IMMUNOEDITING
MAMMARY ADENOCARCINOMA
MATHEMATICAL MODEL
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
title_short Nonclassical roles for IFN-γ and IL-10 in a murine model of immunoedition
title_full Nonclassical roles for IFN-γ and IL-10 in a murine model of immunoedition
title_fullStr Nonclassical roles for IFN-γ and IL-10 in a murine model of immunoedition
title_full_unstemmed Nonclassical roles for IFN-γ and IL-10 in a murine model of immunoedition
title_sort Nonclassical roles for IFN-γ and IL-10 in a murine model of immunoedition
dc.creator.none.fl_str_mv del Giúdice, Antonela
Pagura, Lucas
Capitani, María Celeste
Mainetti, Leandro Ernesto
Scharovsky, Olga Graciela
Di Masso, Ricardo Jose
Rico, Maria Jose
Rozados, Viviana Rosa
author del Giúdice, Antonela
author_facet del Giúdice, Antonela
Pagura, Lucas
Capitani, María Celeste
Mainetti, Leandro Ernesto
Scharovsky, Olga Graciela
Di Masso, Ricardo Jose
Rico, Maria Jose
Rozados, Viviana Rosa
author_role author
author2 Pagura, Lucas
Capitani, María Celeste
Mainetti, Leandro Ernesto
Scharovsky, Olga Graciela
Di Masso, Ricardo Jose
Rico, Maria Jose
Rozados, Viviana Rosa
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv CANCER IMMUNOEDITING
MAMMARY ADENOCARCINOMA
MATHEMATICAL MODEL
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
topic CANCER IMMUNOEDITING
MAMMARY ADENOCARCINOMA
MATHEMATICAL MODEL
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
description Aim: To characterize, by means of univariate and multivariate approaches, the T helper (Th)-1 and Th-2 responses during the different phases of tumor immunoediting. Materials & methods: We used a multivariate principal component analysis applied to analyze the joint behavior of serum concentrations of IFN-γ, IL-2, IL-10 and IL-4, during the different phases of tumor immunoediting, in CBi/L mice challenged with M-406 mammary adenocarcinoma. Results & conclusion: Animals in equilibrium phase showed the widest variations in values of the four cytokines. In this experimental model, the role of IFN-γwould be related to tumor growth and progression, while IL-10 would participate in the antitumor immune response. Lay abstract Breast cancer is a complex, multifactor disease that affects about 10% of women in industrialized countries. The immune system has the ability to monitor the appearance of tumors, but the tumors have the ability to escape such rejection. For this reason, in order to design different therapeutic strategies, it is important to know the different mechanisms that take place when a tumor grows or when it is rejected. Here we sought to elucidate some of these mechanisms.
publishDate 2020
dc.date.none.fl_str_mv 2020-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/174627
del Giúdice, Antonela; Pagura, Lucas; Capitani, María Celeste; Mainetti, Leandro Ernesto; Scharovsky, Olga Graciela; et al.; Nonclassical roles for IFN-γ and IL-10 in a murine model of immunoedition; Future Medicine; Future Science OA; 6; 10; 12-2020; 1-16
2056-5623
CONICET Digital
CONICET
url http://hdl.handle.net/11336/174627
identifier_str_mv del Giúdice, Antonela; Pagura, Lucas; Capitani, María Celeste; Mainetti, Leandro Ernesto; Scharovsky, Olga Graciela; et al.; Nonclassical roles for IFN-γ and IL-10 in a murine model of immunoedition; Future Medicine; Future Science OA; 6; 10; 12-2020; 1-16
2056-5623
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.future-science.com/doi/10.2144/fsoa-2019-0108
info:eu-repo/semantics/altIdentifier/doi/10.2144/fsoa-2019-0108
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Future Medicine
publisher.none.fl_str_mv Future Medicine
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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spelling Nonclassical roles for IFN-γ and IL-10 in a murine model of immunoeditiondel Giúdice, AntonelaPagura, LucasCapitani, María CelesteMainetti, Leandro ErnestoScharovsky, Olga GracielaDi Masso, Ricardo JoseRico, Maria JoseRozados, Viviana RosaCANCER IMMUNOEDITINGMAMMARY ADENOCARCINOMAMATHEMATICAL MODELhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Aim: To characterize, by means of univariate and multivariate approaches, the T helper (Th)-1 and Th-2 responses during the different phases of tumor immunoediting. Materials & methods: We used a multivariate principal component analysis applied to analyze the joint behavior of serum concentrations of IFN-γ, IL-2, IL-10 and IL-4, during the different phases of tumor immunoediting, in CBi/L mice challenged with M-406 mammary adenocarcinoma. Results & conclusion: Animals in equilibrium phase showed the widest variations in values of the four cytokines. In this experimental model, the role of IFN-γwould be related to tumor growth and progression, while IL-10 would participate in the antitumor immune response. Lay abstract Breast cancer is a complex, multifactor disease that affects about 10% of women in industrialized countries. The immune system has the ability to monitor the appearance of tumors, but the tumors have the ability to escape such rejection. For this reason, in order to design different therapeutic strategies, it is important to know the different mechanisms that take place when a tumor grows or when it is rejected. Here we sought to elucidate some of these mechanisms.Fil: del Giúdice, Antonela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Instituto de Genética Experimental. Sección de Oncología Experimental; ArgentinaFil: Pagura, Lucas. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Instituto de Genética Experimental. Sección de Oncología Experimental; ArgentinaFil: Capitani, María Celeste. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Instituto de Genética Experimental. Sección de Oncología Experimental; ArgentinaFil: Mainetti, Leandro Ernesto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Instituto de Genética Experimental. Sección de Oncología Experimental; ArgentinaFil: Scharovsky, Olga Graciela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Instituto de Genética Experimental. Sección de Oncología Experimental; Argentina. Universidad Nacional de Rosario. Consejo de Investigaciones de la Universidad de Rosario; ArgentinaFil: Di Masso, Ricardo Jose. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Instituto de Genética Experimental. Sección de Oncología Experimental; ArgentinaFil: Rico, Maria Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Instituto de Genética Experimental. Sección de Oncología Experimental; ArgentinaFil: Rozados, Viviana Rosa. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Instituto de Genética Experimental. Sección de Oncología Experimental; ArgentinaFuture Medicine2020-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/174627del Giúdice, Antonela; Pagura, Lucas; Capitani, María Celeste; Mainetti, Leandro Ernesto; Scharovsky, Olga Graciela; et al.; Nonclassical roles for IFN-γ and IL-10 in a murine model of immunoedition; Future Medicine; Future Science OA; 6; 10; 12-2020; 1-162056-5623CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.future-science.com/doi/10.2144/fsoa-2019-0108info:eu-repo/semantics/altIdentifier/doi/10.2144/fsoa-2019-0108info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2024-05-08T13:33:43Zoai:ri.conicet.gov.ar:11336/174627instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982024-05-08 13:33:43.754CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
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