Microwave-assisted multicomponent synthesis of julolidines using silica-supported calix[4]arene as heterogeneous catalyst

The application of immobilizing calixarene onto the surface of silica using a sol-gel method, as an efficient heterogeneous catalyst (CX4SO3HSi(n)) for multicomponent Povarov reaction has been described. Catalytic activity of the CX4SO3HSi(n) for the synthesis of julolidines under greener and enviro...

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Detalles Bibliográficos
Autores: Ferreira de Paiva, Walysson, Bastos Braga, Ingredy, Assis, João Vitor de, Bonilla Castañeda, Sandra Milena, Sathicq, Ángel Gabriel, Palermo, Valeria, Romanelli, Gustavo Pablo, Natalino, Ricardo, Silva, Márcio José da, Martins, Felipe T., Carvalho, Gustavo S. G. de, Amarante, Giovanni W., Fernandes, Sergio Antonio
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2019
País:Argentina
Institución:Universidad Nacional de La Plata
Repositorio:SEDICI (UNLP)
Idioma:inglés
OAI Identifier:oai:sedici.unlp.edu.ar:10915/129196
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/129196
Access Level:acceso abierto
Palabra clave:Química
Calixarenes
Heterogeneous catalysis
Julolidines
Microwave-assisted
Multicomponent reactions
Descripción
Sumario:The application of immobilizing calixarene onto the surface of silica using a sol-gel method, as an efficient heterogeneous catalyst (CX4SO3HSi(n)) for multicomponent Povarov reaction has been described. Catalytic activity of the CX4SO3HSi(n) for the synthesis of julolidines under greener and environmentally benign conditions in simple and efficient method was explored. Notably, only 0.5 mol% of the catalyst is sufficient to catalyze the Povarov solvent-free reaction under microwave-assistance. Besides, this protocol allows the construction of four new C–C bonds and two C–N bonds in a single step. To the best of our knowledge, this consists the first silica support calix[4]arene as a heterogeneous catalyst for multicomponent synthesis of julolidines.

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