Anti-Müllerian hormone and inhibin B levels as markers of premature ovarian aging and transition to menopause in type 1 diabetes mellitus

BACKGROUNDSerum anti-Müllerian hormone (AMH) levels decrease early during the transition to menopause and women with type 1 diabetes mellitus (DM1) experience menopause at a younger age. We hypothesized that older women with DM1 will have lower AMH levels than controls.METHODSWe studied ovarian func...

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Detalhes bibliográficos
Autores: Soto, Néstor, Iñiguez, Germán, López, Patricia, Larenas, Gladys, Mujica, Verónica, Rey, Rodolfo Alberto, Codner, Ethel
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2009
País:Argentina
Recursos:Consejo Nacional de Investigaciones Científicas y Técnicas
Repositorio:CONICET Digital (CONICET)
Idioma:inglés
OAI Identifier:oai:ri.conicet.gov.ar:11336/194168
Acesso em linha:http://hdl.handle.net/11336/194168
Access Level:acceso abierto
Palavra-chave:ANTI-MÜLLERIAN HORMONE
INHIBIN B
MENOPAUSE
OVARIAN RESERVE
TYPE 1 DIABETES MELLITUS
https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
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network_acronym_str AR
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repository_id_str
spelling Anti-Müllerian hormone and inhibin B levels as markers of premature ovarian aging and transition to menopause in type 1 diabetes mellitusSoto, NéstorIñiguez, GermánLópez, PatriciaLarenas, GladysMujica, VerónicaRey, Rodolfo AlbertoCodner, EthelANTI-MÜLLERIAN HORMONEINHIBIN BMENOPAUSEOVARIAN RESERVETYPE 1 DIABETES MELLITUShttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3BACKGROUNDSerum anti-Müllerian hormone (AMH) levels decrease early during the transition to menopause and women with type 1 diabetes mellitus (DM1) experience menopause at a younger age. We hypothesized that older women with DM1 will have lower AMH levels than controls.METHODSWe studied ovarian function in women with DM1 (n = 66) and healthy controls (n = 58), all <45 years old. Steroids, gonadotrophins, AMH and inhibin B levels were measured during the follicular phase.RESULTSPiece-wise regression analysis demonstrated that AMH levels begin to decrease at 33 years of age in both groups. This age limit was used to compare data in both groups. AMH levels were lower in DM1 women than in controls >33 years (4.1 ± 4.2 versus 9.5 ± 7.9 pmol/l, mean ± SD, P = 0.006). A higher proportion of women with DM1 showed AMH levels in the menopausal range compared with controls (16.7 versus 3.4, respectively, P = 0.02). For all patients, those with DM1 exhibited lower inhibin B levels than controls (89.3 ± 51.7 versus 113.2 ± 76.0 ng/ml, P < 0.05). FSH and estradiol were similar in both groups. Regression analysis showed an earlier decline in AMH levels in women with DM1 than controls. Even after age adjustment, DM1 was a significant factor for the determination of inhibin B and AMH levels.CONCLUSIONSLower AMH levels in women with DM1 during the fourth decade of life suggest the presence of an earlier decline in the ovarian follicle pool in these women. Further studies are needed to evaluate the mechanism of this complication.Fil: Soto, Néstor. San Borja Arriarán Clinical Hospital; ChileFil: Iñiguez, Germán. Universidad de Chile; ChileFil: López, Patricia. Universidad de Chile; ChileFil: Larenas, Gladys. Universidad de La Frontera; ChileFil: Mujica, Verónica. Hospital Regional de Talca; Chile. Universidad de Talca; ChileFil: Rey, Rodolfo Alberto. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños "Ricardo Gutiérrez"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Codner, Ethel. Universidad de Chile; ChileOxford University Press2009-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/194168Soto, Néstor; Iñiguez, Germán; López, Patricia; Larenas, Gladys; Mujica, Verónica; et al.; Anti-Müllerian hormone and inhibin B levels as markers of premature ovarian aging and transition to menopause in type 1 diabetes mellitus; Oxford University Press; Human Reproduction; 24; 11; 12-2009; 2838-28440268-1161CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1093/humrep/dep276info:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/humrep/article/24/11/2838/627298info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2024-05-08T13:40:47Zoai:ri.conicet.gov.ar:11336/194168instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982024-05-08 13:40:47.567CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Anti-Müllerian hormone and inhibin B levels as markers of premature ovarian aging and transition to menopause in type 1 diabetes mellitus
title Anti-Müllerian hormone and inhibin B levels as markers of premature ovarian aging and transition to menopause in type 1 diabetes mellitus
spellingShingle Anti-Müllerian hormone and inhibin B levels as markers of premature ovarian aging and transition to menopause in type 1 diabetes mellitus
Soto, Néstor
ANTI-MÜLLERIAN HORMONE
INHIBIN B
MENOPAUSE
OVARIAN RESERVE
TYPE 1 DIABETES MELLITUS
https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
title_short Anti-Müllerian hormone and inhibin B levels as markers of premature ovarian aging and transition to menopause in type 1 diabetes mellitus
title_full Anti-Müllerian hormone and inhibin B levels as markers of premature ovarian aging and transition to menopause in type 1 diabetes mellitus
title_fullStr Anti-Müllerian hormone and inhibin B levels as markers of premature ovarian aging and transition to menopause in type 1 diabetes mellitus
title_full_unstemmed Anti-Müllerian hormone and inhibin B levels as markers of premature ovarian aging and transition to menopause in type 1 diabetes mellitus
title_sort Anti-Müllerian hormone and inhibin B levels as markers of premature ovarian aging and transition to menopause in type 1 diabetes mellitus
dc.creator.none.fl_str_mv Soto, Néstor
Iñiguez, Germán
López, Patricia
Larenas, Gladys
Mujica, Verónica
Rey, Rodolfo Alberto
Codner, Ethel
author Soto, Néstor
author_facet Soto, Néstor
Iñiguez, Germán
López, Patricia
Larenas, Gladys
Mujica, Verónica
Rey, Rodolfo Alberto
Codner, Ethel
author_role author
author2 Iñiguez, Germán
López, Patricia
Larenas, Gladys
Mujica, Verónica
Rey, Rodolfo Alberto
Codner, Ethel
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv ANTI-MÜLLERIAN HORMONE
INHIBIN B
MENOPAUSE
OVARIAN RESERVE
TYPE 1 DIABETES MELLITUS
https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
topic ANTI-MÜLLERIAN HORMONE
INHIBIN B
MENOPAUSE
OVARIAN RESERVE
TYPE 1 DIABETES MELLITUS
https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
description BACKGROUNDSerum anti-Müllerian hormone (AMH) levels decrease early during the transition to menopause and women with type 1 diabetes mellitus (DM1) experience menopause at a younger age. We hypothesized that older women with DM1 will have lower AMH levels than controls.METHODSWe studied ovarian function in women with DM1 (n = 66) and healthy controls (n = 58), all <45 years old. Steroids, gonadotrophins, AMH and inhibin B levels were measured during the follicular phase.RESULTSPiece-wise regression analysis demonstrated that AMH levels begin to decrease at 33 years of age in both groups. This age limit was used to compare data in both groups. AMH levels were lower in DM1 women than in controls >33 years (4.1 ± 4.2 versus 9.5 ± 7.9 pmol/l, mean ± SD, P = 0.006). A higher proportion of women with DM1 showed AMH levels in the menopausal range compared with controls (16.7 versus 3.4, respectively, P = 0.02). For all patients, those with DM1 exhibited lower inhibin B levels than controls (89.3 ± 51.7 versus 113.2 ± 76.0 ng/ml, P < 0.05). FSH and estradiol were similar in both groups. Regression analysis showed an earlier decline in AMH levels in women with DM1 than controls. Even after age adjustment, DM1 was a significant factor for the determination of inhibin B and AMH levels.CONCLUSIONSLower AMH levels in women with DM1 during the fourth decade of life suggest the presence of an earlier decline in the ovarian follicle pool in these women. Further studies are needed to evaluate the mechanism of this complication.
publishDate 2009
dc.date.none.fl_str_mv 2009-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/194168
Soto, Néstor; Iñiguez, Germán; López, Patricia; Larenas, Gladys; Mujica, Verónica; et al.; Anti-Müllerian hormone and inhibin B levels as markers of premature ovarian aging and transition to menopause in type 1 diabetes mellitus; Oxford University Press; Human Reproduction; 24; 11; 12-2009; 2838-2844
0268-1161
CONICET Digital
CONICET
url http://hdl.handle.net/11336/194168
identifier_str_mv Soto, Néstor; Iñiguez, Germán; López, Patricia; Larenas, Gladys; Mujica, Verónica; et al.; Anti-Müllerian hormone and inhibin B levels as markers of premature ovarian aging and transition to menopause in type 1 diabetes mellitus; Oxford University Press; Human Reproduction; 24; 11; 12-2009; 2838-2844
0268-1161
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1093/humrep/dep276
info:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/humrep/article/24/11/2838/627298
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Oxford University Press
publisher.none.fl_str_mv Oxford University Press
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 15.811543

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