Enantiocomplementary Access to Carba-Analogs of C-Nucleoside Derivatives by Recombinant Baeyer-Villiger Monooxygenases

A novel and stereoselective synthetic route towards carba-C-nucleosides was investigated applying an enantiodivergent biooxidation strategy by two different Baeyer–Villiger monooxygenases. Within only three chemo-enzymatic steps it was possible to introduce four chiral centers starting from commerci...

Full description

Bibliographic Details
Authors: Bianchi, Dario Alejandro, Moran Ramallal, Roberto, Iqbal, Naseem, Rudroff, Florian, Mihovilovic, Marko D.
Format: article
Status:Published version
Publication Date:2013
Country:Argentina
Institution:Consejo Nacional de Investigaciones Científicas y Técnicas
Repository:CONICET Digital (CONICET)
Language:English
OAI Identifier:oai:ri.conicet.gov.ar:11336/6029
Online Access:http://hdl.handle.net/11336/6029
Access Level:Open access
Keyword:Baeyer-Villiger Monooxygenase
C-Nucleoside
Carba-Showdomycin
Carba-C-Nucleoside
https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
Description
Summary:A novel and stereoselective synthetic route towards carba-C-nucleosides was investigated applying an enantiodivergent biooxidation strategy by two different Baeyer–Villiger monooxygenases. Within only three chemo-enzymatic steps it was possible to introduce four chiral centers starting from commercially available non-chiral starting material.

Similar Items