Deleterious metabolic effects of high fructose intake: The preventive effect of Lactobacillus kefiri administration

Modern lifestyle and diets have been associated with metabolic disorders and an imbalance in the normal gut microbiota. Probiotics are widely known for their health beneficial properties targeting the gut microbial ecosystem. The aim of our study was to evaluate the preventive effect of Lactobacillu...

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Autores: Zubiría, María Guillermina, Gambaro, Sabrina Eliana, Rey, Maria Amanda, Carasi, Paula, Serradell, María de los Ángeles, Giovambattista, Andres
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2017
País:Argentina
Institución:Consejo Nacional de Investigaciones Científicas y Técnicas
Repositorio:CONICET Digital (CONICET)
Idioma:inglés
OAI Identifier:oai:ri.conicet.gov.ar:11336/51695
Acceso en línea:http://hdl.handle.net/11336/51695
Access Level:acceso abierto
Palabra clave:Probiotics
Fructose
fructose-rich diet
https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
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network_acronym_str AR
network_name_str Argentina
repository_id_str
dc.title.none.fl_str_mv Deleterious metabolic effects of high fructose intake: The preventive effect of Lactobacillus kefiri administration
title Deleterious metabolic effects of high fructose intake: The preventive effect of Lactobacillus kefiri administration
spellingShingle Deleterious metabolic effects of high fructose intake: The preventive effect of Lactobacillus kefiri administration
Zubiría, María Guillermina
Probiotics
Fructose
fructose-rich diet
https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
title_short Deleterious metabolic effects of high fructose intake: The preventive effect of Lactobacillus kefiri administration
title_full Deleterious metabolic effects of high fructose intake: The preventive effect of Lactobacillus kefiri administration
title_fullStr Deleterious metabolic effects of high fructose intake: The preventive effect of Lactobacillus kefiri administration
title_full_unstemmed Deleterious metabolic effects of high fructose intake: The preventive effect of Lactobacillus kefiri administration
title_sort Deleterious metabolic effects of high fructose intake: The preventive effect of Lactobacillus kefiri administration
dc.creator.none.fl_str_mv Zubiría, María Guillermina
Gambaro, Sabrina Eliana
Rey, Maria Amanda
Carasi, Paula
Serradell, María de los Ángeles
Giovambattista, Andres
author Zubiría, María Guillermina
author_facet Zubiría, María Guillermina
Gambaro, Sabrina Eliana
Rey, Maria Amanda
Carasi, Paula
Serradell, María de los Ángeles
Giovambattista, Andres
author_role author
author2 Gambaro, Sabrina Eliana
Rey, Maria Amanda
Carasi, Paula
Serradell, María de los Ángeles
Giovambattista, Andres
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Probiotics
Fructose
fructose-rich diet
https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
topic Probiotics
Fructose
fructose-rich diet
https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
description Modern lifestyle and diets have been associated with metabolic disorders and an imbalance in the normal gut microbiota. Probiotics are widely known for their health beneficial properties targeting the gut microbial ecosystem. The aim of our study was to evaluate the preventive effect of Lactobacillus kefiri (L. kefiri) administration in a fructose-rich diet (FRD) mice model. Mice were provided with tap water or fructose-added (20% ω/ν) drinking water supplemented or not with L. kefiri. Results showed that probiotic administration prevented weight gain and epidydimal adipose tissue (EAT) expansion, with partial reversion of the adipocyte hypertrophy developed by FRD. Moreover, the probiotic prevented the increase of plasma triglycerides and leptin, together with the liver triglyceride content. Leptin adipocyte secretion was also improved by L. kefiri, being able to respond to an insulin stimulus. Glucose intolerance was partially prevented by L. kefiri treatment (GTT) and local inflammation (TNFα; IL1β; IL6 and INFγ) was completely inhibited in EAT. L. kefiri supplementation generated an impact on gut microbiota composition, changing Bacteroidetes and Firmicutes profiles. Overall, our results indicate that the administration of probiotics prevents the deleterious effects of FRD intake and should therefore be promoted to improve metabolic disorders.
publishDate 2017
dc.date.none.fl_str_mv 2017-05
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/51695
Zubiría, María Guillermina; Gambaro, Sabrina Eliana; Rey, Maria Amanda; Carasi, Paula; Serradell, María de los Ángeles; et al.; Deleterious metabolic effects of high fructose intake: The preventive effect of Lactobacillus kefiri administration; MDPI AG; Nutrients; 9; 5; 5-2017; 1-17
2072-6643
CONICET Digital
CONICET
url http://hdl.handle.net/11336/51695
identifier_str_mv Zubiría, María Guillermina; Gambaro, Sabrina Eliana; Rey, Maria Amanda; Carasi, Paula; Serradell, María de los Ángeles; et al.; Deleterious metabolic effects of high fructose intake: The preventive effect of Lactobacillus kefiri administration; MDPI AG; Nutrients; 9; 5; 5-2017; 1-17
2072-6643
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.mdpi.com/2072-6643/9/5/470
info:eu-repo/semantics/altIdentifier/doi/10.3390/nu9050470
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv MDPI AG
publisher.none.fl_str_mv MDPI AG
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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spelling Deleterious metabolic effects of high fructose intake: The preventive effect of Lactobacillus kefiri administrationZubiría, María GuillerminaGambaro, Sabrina ElianaRey, Maria AmandaCarasi, PaulaSerradell, María de los ÁngelesGiovambattista, AndresProbioticsFructosefructose-rich diethttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Modern lifestyle and diets have been associated with metabolic disorders and an imbalance in the normal gut microbiota. Probiotics are widely known for their health beneficial properties targeting the gut microbial ecosystem. The aim of our study was to evaluate the preventive effect of Lactobacillus kefiri (L. kefiri) administration in a fructose-rich diet (FRD) mice model. Mice were provided with tap water or fructose-added (20% ω/ν) drinking water supplemented or not with L. kefiri. Results showed that probiotic administration prevented weight gain and epidydimal adipose tissue (EAT) expansion, with partial reversion of the adipocyte hypertrophy developed by FRD. Moreover, the probiotic prevented the increase of plasma triglycerides and leptin, together with the liver triglyceride content. Leptin adipocyte secretion was also improved by L. kefiri, being able to respond to an insulin stimulus. Glucose intolerance was partially prevented by L. kefiri treatment (GTT) and local inflammation (TNFα; IL1β; IL6 and INFγ) was completely inhibited in EAT. L. kefiri supplementation generated an impact on gut microbiota composition, changing Bacteroidetes and Firmicutes profiles. Overall, our results indicate that the administration of probiotics prevents the deleterious effects of FRD intake and should therefore be promoted to improve metabolic disorders.Fil: Zubiría, María Guillermina. Universidad Nacional de La Plata; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Multidisciplinario de Biología Celular. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Multidisciplinario de Biología Celular. Universidad Nacional de La Plata. Instituto Multidisciplinario de Biología Celular; ArgentinaFil: Gambaro, Sabrina Eliana. Universidad Nacional de La Plata; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Multidisciplinario de Biología Celular. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Multidisciplinario de Biología Celular. Universidad Nacional de La Plata. Instituto Multidisciplinario de Biología Celular; ArgentinaFil: Rey, Maria Amanda. Universidad Nacional de La Plata; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Multidisciplinario de Biología Celular. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Multidisciplinario de Biología Celular. Universidad Nacional de La Plata. Instituto Multidisciplinario de Biología Celular; ArgentinaFil: Carasi, Paula. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de la Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas. Cátedra de Microbiología General; ArgentinaFil: Serradell, María de los Ángeles. Universidad Nacional de La Plata; Argentina. Universidad Nacional de la Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas. Cátedra de Microbiología General; ArgentinaFil: Giovambattista, Andres. Universidad Nacional de La Plata; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Multidisciplinario de Biología Celular. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Multidisciplinario de Biología Celular. Universidad Nacional de La Plata. Instituto Multidisciplinario de Biología Celular; ArgentinaMDPI AG2017-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/51695Zubiría, María Guillermina; Gambaro, Sabrina Eliana; Rey, Maria Amanda; Carasi, Paula; Serradell, María de los Ángeles; et al.; Deleterious metabolic effects of high fructose intake: The preventive effect of Lactobacillus kefiri administration; MDPI AG; Nutrients; 9; 5; 5-2017; 1-172072-6643CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://www.mdpi.com/2072-6643/9/5/470info:eu-repo/semantics/altIdentifier/doi/10.3390/nu9050470info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2024-05-08T14:13:45Zoai:ri.conicet.gov.ar:11336/51695instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982024-05-08 14:13:45.239CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
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