Thiol-free chemoenzymatic synthesis of β-ketosulfides
A preparation of β-ketosulfides avoiding the use of thiols is described. The combination of a multicomponent reaction and a lipase-catalysed hydrolysis has been developed in order to obtain high chemical diversity employing a single sulfur donor. This methodology for the selective synthesis of a set...
| Autores: | , , , , |
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| Tipo de documento: | artigo |
| Estado: | Versão publicada |
| Data de publicação: | 2019 |
| País: | Argentina |
| Recursos: | Consejo Nacional de Investigaciones Científicas y Técnicas |
| Repositório: | CONICET Digital (CONICET) |
| Idioma: | inglês |
| OAI Identifier: | oai:ri.conicet.gov.ar:11336/125633 |
| Acesso em linha: | http://hdl.handle.net/11336/125633 |
| Access Level: | Acceso aberto |
| Palavra-chave: | KETOSULFIDES LIPASE MULTICOMPONENT SULFOXIDE THIOL-FREE https://purl.org/becyt/ford/1.4 https://purl.org/becyt/ford/1 |
| Resumo: | A preparation of β-ketosulfides avoiding the use of thiols is described. The combination of a multicomponent reaction and a lipase-catalysed hydrolysis has been developed in order to obtain high chemical diversity employing a single sulfur donor. This methodology for the selective synthesis of a set of β-ketosulfides is performed under mild conditions and can be set up in one-pot two-step and on a gram-scale. |
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