Assessment of Cross-reactive Host-pathogen Antibodies in Patients With Different Stages of Chronic Chagas Disease

Trypanosoma cruzi infection has been shown to induce humoral autoimmune responses against host antigens tissues. Particularly, antibodies cross-reacting with myocardial antigens may play a role in the development of the severe forms of chronic Chagas disease. The aim of this study was to determine t...

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Bibliographic Details
Authors: Vicco, Miguel Hernán, Ferini, Facundo, Rodeles Antonelli, Luz María, Cardona, Paula, Bontempi, Iván, Lioi, Susana, Beloscar, Juan, Nara, Takeshi, Marcipar, Ivan Sergio, Bottasso, Oscar Adelmo
Format: article
Status:Published version
Publication Date:2013
Country:Argentina
Institution:Consejo Nacional de Investigaciones Científicas y Técnicas
Repository:CONICET Digital (CONICET)
Language:English
OAI Identifier:oai:ri.conicet.gov.ar:11336/1689
Online Access:http://hdl.handle.net/11336/1689
Access Level:Open access
Keyword:Enfermedad de Chagas
Autoanticuerpos
Miocardiopatía
B13
https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
https://purl.org/becyt/ford/3.2
Description
Summary:Trypanosoma cruzi infection has been shown to induce humoral autoimmune responses against host antigens tissues. Particularly, antibodies cross-reacting with myocardial antigens may play a role in the development of the severe forms of chronic Chagas disease. The aim of this study was to determine the association between clinical stage of the disease and the presence of autoantibodies in patients with chronic Chagasic disease.

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