Expression of Fcγ receptors type II (FcγRII) in chronic lymphocytic leukemia B cells [4]

We have read with interest the paper from Damle et al analyzing the surface membrane phenotype of B lymphocytes in chronic lymphocytic leukemia (B-CLL). The authors stated that the leukemic cells from all B-CLL patients evaluated (irrespective of immunoglobulin heavy chain (IgVH) gene mutational sta...

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Bibliographic Details
Authors: Gamberale, Romina, Geffner, Jorge Raúl, Sanjurjo, Julieta, Fernandez Calloti, Paula X., Arrosagaray, Guillermo, Sánchez Ávalos, Julio César Américo, Giordano, Mirta Nilda
Format: article
Status:Published version
Publication Date:2003
Country:Argentina
Institution:Consejo Nacional de Investigaciones Científicas y Técnicas
Repository:CONICET Digital (CONICET)
Language:English
OAI Identifier:oai:ri.conicet.gov.ar:11336/71328
Online Access:http://hdl.handle.net/11336/71328
Access Level:Open access
Keyword:B Lymphocytes
Leukemia
Igvh
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
Description
Summary:We have read with interest the paper from Damle et al analyzing the surface membrane phenotype of B lymphocytes in chronic lymphocytic leukemia (B-CLL). The authors stated that the leukemic cells from all B-CLL patients evaluated (irrespective of immunoglobulin heavy chain (IgVH) gene mutational status) bear the phenotype of antigen-experienced B cells based, among other features, on the very low expression of Fcγ receptors type IIb (FcγRIIb, CD32), which is the main isoform of FcγRII in B lymphocytes.

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