Different evolution of S. aureus methicillin-resistant and methicillin-susceptible infections, Argentina

Barcudi, Danilo Andres; Blasko, Enrique Gabriel; Gonzalez, María José; Gagetti, Paula Silvana; Lamberghini, Ricardo; Garnero, Analía; Sarkis, Claudia; Faccone, Diego Francisco; Lucero, Celeste; Tosoroni, Dario; Bocco, Jose Luis; Corso, Alejandra; Sola, Claudia del Valle

Different evolution of S. aureus methicillin-resistant and methicillin-susceptible infections, Argentina

Staphylococcus aureus-(SA) is widespread among healthcare-associated-(HA) and the community-associated-(CA) infections. However, the contributions of MRSA and MSSA to the SA overall burden remain unclear. In a nationally-representative-survey conducted in Argentina, 668 SA clinical isolates from 60...

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Detalhes bibliográficos
Autores:	Barcudi, Danilo Andres, Blasko, Enrique Gabriel, Gonzalez, María José, Gagetti, Paula Silvana, Lamberghini, Ricardo, Garnero, Analía, Sarkis, Claudia, Faccone, Diego Francisco, Lucero, Celeste, Tosoroni, Dario, Bocco, Jose Luis, Corso, Alejandra, Sola, Claudia del Valle
Tipo de documento:	artigo
Estado:	Versão publicada
Data de publicação:	2023
País:	Argentina
Recursos:	Consejo Nacional de Investigaciones Científicas y Técnicas
Repositório:	CONICET Digital (CONICET)
Idioma:	inglês
OAI Identifier:	oai:ri.conicet.gov.ar:11336/220401
Acesso em linha:	http://hdl.handle.net/11336/220401
Access Level:	Acceso aberto
Palavra-chave:	STAPHYLOCOCCUS AUREUS MRSA METHICILLIN-RESISTANCE EVOLUTION https://purl.org/becyt/ford/3.3 https://purl.org/becyt/ford/3

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oai_identifier_str	oai:ri.conicet.gov.ar:11336/220401
network_acronym_str	AR
network_name_str	Argentina
repository_id_str
dc.title.none.fl_str_mv	Different evolution of S. aureus methicillin-resistant and methicillin-susceptible infections, Argentina
title	Different evolution of S. aureus methicillin-resistant and methicillin-susceptible infections, Argentina
spellingShingle	Different evolution of S. aureus methicillin-resistant and methicillin-susceptible infections, Argentina Barcudi, Danilo Andres STAPHYLOCOCCUS AUREUS MRSA METHICILLIN-RESISTANCE EVOLUTION https://purl.org/becyt/ford/3.3 https://purl.org/becyt/ford/3
title_short	Different evolution of S. aureus methicillin-resistant and methicillin-susceptible infections, Argentina
title_full	Different evolution of S. aureus methicillin-resistant and methicillin-susceptible infections, Argentina
title_fullStr	Different evolution of S. aureus methicillin-resistant and methicillin-susceptible infections, Argentina
title_full_unstemmed	Different evolution of S. aureus methicillin-resistant and methicillin-susceptible infections, Argentina
title_sort	Different evolution of S. aureus methicillin-resistant and methicillin-susceptible infections, Argentina
dc.creator.none.fl_str_mv	Barcudi, Danilo Andres Blasko, Enrique Gabriel Gonzalez, María José Gagetti, Paula Silvana Lamberghini, Ricardo Garnero, Analía Sarkis, Claudia Faccone, Diego Francisco Lucero, Celeste Tosoroni, Dario Bocco, Jose Luis Corso, Alejandra Sola, Claudia del Valle
author	Barcudi, Danilo Andres
author_facet	Barcudi, Danilo Andres Blasko, Enrique Gabriel Gonzalez, María José Gagetti, Paula Silvana Lamberghini, Ricardo Garnero, Analía Sarkis, Claudia Faccone, Diego Francisco Lucero, Celeste Tosoroni, Dario Bocco, Jose Luis Corso, Alejandra Sola, Claudia del Valle
author_role	author
author2	Blasko, Enrique Gabriel Gonzalez, María José Gagetti, Paula Silvana Lamberghini, Ricardo Garnero, Analía Sarkis, Claudia Faccone, Diego Francisco Lucero, Celeste Tosoroni, Dario Bocco, Jose Luis Corso, Alejandra Sola, Claudia del Valle
author2_role	author author author author author author author author author author author author
dc.subject.none.fl_str_mv	STAPHYLOCOCCUS AUREUS MRSA METHICILLIN-RESISTANCE EVOLUTION https://purl.org/becyt/ford/3.3 https://purl.org/becyt/ford/3
topic	STAPHYLOCOCCUS AUREUS MRSA METHICILLIN-RESISTANCE EVOLUTION https://purl.org/becyt/ford/3.3 https://purl.org/becyt/ford/3
description	Staphylococcus aureus-(SA) is widespread among healthcare-associated-(HA) and the community-associated-(CA) infections. However, the contributions of MRSA and MSSA to the SA overall burden remain unclear. In a nationally-representative-survey conducted in Argentina, 668 SA clinical isolates from 60 hospitals were examined in a prospective, cross-sectional, multicenter study in April 2015. The study aimed to analyze MRSA molecular epidemiology, estimate overall SA infection incidence (MSSA, MRSA, and genotypes) in community-onset (CO: HACO, Healthcare Associated-CO and CACO, Community-Associated-CO) and healthcare-onset (HO: HAHO, Healthcare-associated-HO) infections, stratified by age groups. Additionally temporal evolution was estimated by comparing this study´s (2015) incidence values with a previous study (2009) in the same region. Erythromycin-resistant-MSSA and all MRSA strains were genetically typed. The SA total-infections (TI) overall-incidence was 49.1/100,000 monthly-visits, 25.1 and 24.0 for MRSA and MSSA respectively (P=0.5889), in April 2015. In adults with invasive infections (INVI), MSSA was 15.7 and MRSA was 11.8 (P=0.0288), 1.3-fold higher. HA SA infections, both MSSA and MRSA, surpassed CA infections by over threefold. During 2009-2015, there was a significant 23.4% increase in the SA infections overall incidence, mainly driven by MSSA, notably a 54.2% increase in INVI among adults, while MRSA infection rates remained stable. The MSSA rise was accompanied by increased antimicrobial resistance, particularly to erythromycin, linked to MSSA-CC398-t1451-ermT + - IEC+ -pvl- emergence. The SA-infections rise was primarily attributed to community-onset infections (37.3% and 62.4% increase for TI and INVI, respectively), particularly HACO MSSA and HACO-MRSA in adults, as well as CACO-MSSA. The main CA-MRSA-PFGEtypeN-ST30-SCCmecIVc-PVL+/- clone along with other clones (USA300-ST8-IV-LV-PVL+/- , Journal Pre-proof 5 PFGE-typeDD-ST97-IV- PVL- ) added to rather than replaced CA-MRSA-PFGE-typeI-ST5- SCCmecIVa-PVL+/- clone in HA invasive-infections. They also displaced clone HA-MRSA PFGE-typeA-ST5-SCCmecI, mainly in HAHO infections The overall-burden of SA infections is rising in Argentina, driven primarily by community onset MSSA, particularly in adults, linked to increased erythromycin-resistance and MSSACC398-t1451-ermT + -IEC+ -pvl- emergence. Novel knowledge and transmission-control strategies are required for MSSA
publishDate	2023
dc.date.none.fl_str_mv	2023-11
dc.type.none.fl_str_mv	info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo
format	article
status_str	publishedVersion
dc.identifier.none.fl_str_mv	http://hdl.handle.net/11336/220401 Barcudi, Danilo Andres; Blasko, Enrique Gabriel; Gonzalez, María José; Gagetti, Paula Silvana; Lamberghini, Ricardo; et al.; Different evolution of S. aureus methicillin-resistant and methicillin-susceptible infections, Argentina; Elsevier; Heliyon; 11-2023; 1-53 2405-8440 CONICET Digital CONICET
url	http://hdl.handle.net/11336/220401
identifier_str_mv	Barcudi, Danilo Andres; Blasko, Enrique Gabriel; Gonzalez, María José; Gagetti, Paula Silvana; Lamberghini, Ricardo; et al.; Different evolution of S. aureus methicillin-resistant and methicillin-susceptible infections, Argentina; Elsevier; Heliyon; 11-2023; 1-53 2405-8440 CONICET Digital CONICET
dc.language.none.fl_str_mv	eng
language	eng
dc.relation.none.fl_str_mv	info:eu-repo/semantics/altIdentifier/url/https://linkinghub.elsevier.com/retrieve/pii/S2405844023098183 info:eu-repo/semantics/altIdentifier/doi/10.1016/j.heliyon.2023.e22610
dc.rights.none.fl_str_mv	info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv	openAccess
rights_invalid_str_mv	https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv	application/pdf application/pdf
dc.publisher.none.fl_str_mv	Elsevier
publisher.none.fl_str_mv	Elsevier
dc.source.none.fl_str_mv	reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas
instname_str	Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str	CONICET Digital (CONICET)
collection	CONICET Digital (CONICET)
repository.name.fl_str_mv	CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv	dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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spelling	Different evolution of S. aureus methicillin-resistant and methicillin-susceptible infections, ArgentinaBarcudi, Danilo AndresBlasko, Enrique GabrielGonzalez, María JoséGagetti, Paula SilvanaLamberghini, RicardoGarnero, AnalíaSarkis, ClaudiaFaccone, Diego FranciscoLucero, CelesteTosoroni, DarioBocco, Jose LuisCorso, AlejandraSola, Claudia del ValleSTAPHYLOCOCCUS AUREUSMRSAMETHICILLIN-RESISTANCEEVOLUTIONhttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Staphylococcus aureus-(SA) is widespread among healthcare-associated-(HA) and the community-associated-(CA) infections. However, the contributions of MRSA and MSSA to the SA overall burden remain unclear. In a nationally-representative-survey conducted in Argentina, 668 SA clinical isolates from 60 hospitals were examined in a prospective, cross-sectional, multicenter study in April 2015. The study aimed to analyze MRSA molecular epidemiology, estimate overall SA infection incidence (MSSA, MRSA, and genotypes) in community-onset (CO: HACO, Healthcare Associated-CO and CACO, Community-Associated-CO) and healthcare-onset (HO: HAHO, Healthcare-associated-HO) infections, stratified by age groups. Additionally temporal evolution was estimated by comparing this study´s (2015) incidence values with a previous study (2009) in the same region. Erythromycin-resistant-MSSA and all MRSA strains were genetically typed. The SA total-infections (TI) overall-incidence was 49.1/100,000 monthly-visits, 25.1 and 24.0 for MRSA and MSSA respectively (P=0.5889), in April 2015. In adults with invasive infections (INVI), MSSA was 15.7 and MRSA was 11.8 (P=0.0288), 1.3-fold higher. HA SA infections, both MSSA and MRSA, surpassed CA infections by over threefold. During 2009-2015, there was a significant 23.4% increase in the SA infections overall incidence, mainly driven by MSSA, notably a 54.2% increase in INVI among adults, while MRSA infection rates remained stable. The MSSA rise was accompanied by increased antimicrobial resistance, particularly to erythromycin, linked to MSSA-CC398-t1451-ermT + - IEC+ -pvl- emergence. The SA-infections rise was primarily attributed to community-onset infections (37.3% and 62.4% increase for TI and INVI, respectively), particularly HACO MSSA and HACO-MRSA in adults, as well as CACO-MSSA. The main CA-MRSA-PFGEtypeN-ST30-SCCmecIVc-PVL+/- clone along with other clones (USA300-ST8-IV-LV-PVL+/- , Journal Pre-proof 5 PFGE-typeDD-ST97-IV- PVL- ) added to rather than replaced CA-MRSA-PFGE-typeI-ST5- SCCmecIVa-PVL+/- clone in HA invasive-infections. They also displaced clone HA-MRSA PFGE-typeA-ST5-SCCmecI, mainly in HAHO infections The overall-burden of SA infections is rising in Argentina, driven primarily by community onset MSSA, particularly in adults, linked to increased erythromycin-resistance and MSSACC398-t1451-ermT + -IEC+ -pvl- emergence. Novel knowledge and transmission-control strategies are required for MSSAFil: Barcudi, Danilo Andres. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; ArgentinaFil: Blasko, Enrique Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; ArgentinaFil: Gonzalez, María José. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; ArgentinaFil: Gagetti, Paula Silvana. Dirección Nacional de Institutos de Investigación. Administración Nacional de Laboratorios e Institutos de Salud. Instituto Nacional de Enfermedades Infecciosas. Área de Antimicrobianos; ArgentinaFil: Lamberghini, Ricardo. Universidad Nacional de Córdoba; ArgentinaFil: Garnero, Analía. Gobierno de la Provincia de Cordoba. Ministerio de Salud. Hospital de Niños de la Santísima Trinidad.; ArgentinaFil: Sarkis, Claudia. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; ArgentinaFil: Faccone, Diego Francisco. Dirección Nacional de Institutos de Investigación. Administración Nacional de Laboratorios e Institutos de Salud. Instituto Nacional de Enfermedades Infecciosas. Área de Antimicrobianos; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Lucero, Celeste. Dirección Nacional de Institutos de Investigación. Administración Nacional de Laboratorios e Institutos de Salud. Instituto Nacional de Enfermedades Infecciosas. Área de Antimicrobianos; ArgentinaFil: Tosoroni, Dario. Universidad Nacional de Córdoba; ArgentinaFil: Bocco, Jose Luis. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; ArgentinaFil: Corso, Alejandra. Dirección Nacional de Institutos de Investigación. Administración Nacional de Laboratorios e Institutos de Salud. Instituto Nacional de Enfermedades Infecciosas. Área de Antimicrobianos; ArgentinaFil: Sola, Claudia del Valle. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; ArgentinaElsevier2023-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/220401Barcudi, Danilo Andres; Blasko, Enrique Gabriel; Gonzalez, María José; Gagetti, Paula Silvana; Lamberghini, Ricardo; et al.; Different evolution of S. aureus methicillin-resistant and methicillin-susceptible infections, Argentina; Elsevier; Heliyon; 11-2023; 1-532405-8440CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://linkinghub.elsevier.com/retrieve/pii/S2405844023098183info:eu-repo/semantics/altIdentifier/doi/10.1016/j.heliyon.2023.e22610info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2024-05-08T14:24:48Zoai:ri.conicet.gov.ar:11336/220401instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982024-05-08 14:24:49.166CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
score	15,811543

Different evolution of S. aureus methicillin-resistant and methicillin-susceptible infections, Argentina

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