Glypican-3 reexpression regulates apoptosis in murine adenocarcinoma mammary cells modulating PI3K/Akt and p38MAPK signaling pathways

Glypican-3 (GPC3) is a proteoglycan involved in proliferation and cell survival. Several reports demonstrated that GPC3 is downregulated in some tumors, such as breast cancer. Previously, we determined that GPC3 reexpression in the murine mammary adenocarcinoma LM3 cells induced an impairment of the...

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Autores: Buchanan, Cecilia, Stigliano, Ivan Daniel, Garay Malpartida, H. M., Rodrigues Gomes, L., Puricelli, Lydia Ines, Sogayar, M.C., Bal, Elisa Dora, Peters, María Giselle
Tipo de documento: artigo
Estado:Versão publicada
Data de publicação:2010
País:Argentina
Recursos:Consejo Nacional de Investigaciones Científicas y Técnicas
Repositório:CONICET Digital (CONICET)
Idioma:inglês
OAI Identifier:oai:ri.conicet.gov.ar:11336/117735
Acesso em linha:http://hdl.handle.net/11336/117735
Access Level:Acceso aberto
Palavra-chave:APOPTOSIS
BREAST CANCER
GLYPICAN-3
P38MAPK PATHWAY
PI3K/AKT PATHWAY
https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
id AR_0d6436ca2ba3c10a7d692bdf2b248ff1
oai_identifier_str oai:ri.conicet.gov.ar:11336/117735
network_acronym_str AR
network_name_str Argentina
repository_id_str
dc.title.none.fl_str_mv Glypican-3 reexpression regulates apoptosis in murine adenocarcinoma mammary cells modulating PI3K/Akt and p38MAPK signaling pathways
title Glypican-3 reexpression regulates apoptosis in murine adenocarcinoma mammary cells modulating PI3K/Akt and p38MAPK signaling pathways
spellingShingle Glypican-3 reexpression regulates apoptosis in murine adenocarcinoma mammary cells modulating PI3K/Akt and p38MAPK signaling pathways
Buchanan, Cecilia
APOPTOSIS
BREAST CANCER
GLYPICAN-3
P38MAPK PATHWAY
PI3K/AKT PATHWAY
https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
title_short Glypican-3 reexpression regulates apoptosis in murine adenocarcinoma mammary cells modulating PI3K/Akt and p38MAPK signaling pathways
title_full Glypican-3 reexpression regulates apoptosis in murine adenocarcinoma mammary cells modulating PI3K/Akt and p38MAPK signaling pathways
title_fullStr Glypican-3 reexpression regulates apoptosis in murine adenocarcinoma mammary cells modulating PI3K/Akt and p38MAPK signaling pathways
title_full_unstemmed Glypican-3 reexpression regulates apoptosis in murine adenocarcinoma mammary cells modulating PI3K/Akt and p38MAPK signaling pathways
title_sort Glypican-3 reexpression regulates apoptosis in murine adenocarcinoma mammary cells modulating PI3K/Akt and p38MAPK signaling pathways
dc.creator.none.fl_str_mv Buchanan, Cecilia
Stigliano, Ivan Daniel
Garay Malpartida, H. M.
Rodrigues Gomes, L.
Puricelli, Lydia Ines
Sogayar, M.C.
Bal, Elisa Dora
Peters, María Giselle
author Buchanan, Cecilia
author_facet Buchanan, Cecilia
Stigliano, Ivan Daniel
Garay Malpartida, H. M.
Rodrigues Gomes, L.
Puricelli, Lydia Ines
Sogayar, M.C.
Bal, Elisa Dora
Peters, María Giselle
author_role author
author2 Stigliano, Ivan Daniel
Garay Malpartida, H. M.
Rodrigues Gomes, L.
Puricelli, Lydia Ines
Sogayar, M.C.
Bal, Elisa Dora
Peters, María Giselle
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv APOPTOSIS
BREAST CANCER
GLYPICAN-3
P38MAPK PATHWAY
PI3K/AKT PATHWAY
https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
topic APOPTOSIS
BREAST CANCER
GLYPICAN-3
P38MAPK PATHWAY
PI3K/AKT PATHWAY
https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
description Glypican-3 (GPC3) is a proteoglycan involved in proliferation and cell survival. Several reports demonstrated that GPC3 is downregulated in some tumors, such as breast cancer. Previously, we determined that GPC3 reexpression in the murine mammary adenocarcinoma LM3 cells induced an impairment of their invasive and metastatic capacities, associated with a decrease of their motility and an increase of their cell death. We demonstrated that GPC3 inhibits canonical Wnt signaling, as well as it activates non canonical pathway. Now, we identified signaling pathways responsible for the pro-apoptotic role of GPC3 in LM3 cells. We found for the first time that GPC3 inhibits the PI3K/Akt anti-apoptotic pathway while it stimulates the p38MAPK stress-activated one. We report a concomitant modulation of CDK inhibitors as well as of pro- and anti-apoptotic molecules. Our results provide new clues regarding the mechanism involved in the modulation induced by GPC3 of mammary tumor cell growth and survival.
publishDate 2010
dc.date.none.fl_str_mv 2010-02
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/117735
Buchanan, Cecilia; Stigliano, Ivan Daniel; Garay Malpartida, H. M.; Rodrigues Gomes, L.; Puricelli, Lydia Ines; et al.; Glypican-3 reexpression regulates apoptosis in murine adenocarcinoma mammary cells modulating PI3K/Akt and p38MAPK signaling pathways; Springer; Breast Cancer Research and Treatment; 119; 3; 2-2010; 559-574
0167-6806
CONICET Digital
CONICET
url http://hdl.handle.net/11336/117735
identifier_str_mv Buchanan, Cecilia; Stigliano, Ivan Daniel; Garay Malpartida, H. M.; Rodrigues Gomes, L.; Puricelli, Lydia Ines; et al.; Glypican-3 reexpression regulates apoptosis in murine adenocarcinoma mammary cells modulating PI3K/Akt and p38MAPK signaling pathways; Springer; Breast Cancer Research and Treatment; 119; 3; 2-2010; 559-574
0167-6806
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007/s10549-009-0362-9
info:eu-repo/semantics/altIdentifier/doi/10.1007/s10549-009-0362-9
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Springer
publisher.none.fl_str_mv Springer
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1799195246948515840
spelling Glypican-3 reexpression regulates apoptosis in murine adenocarcinoma mammary cells modulating PI3K/Akt and p38MAPK signaling pathwaysBuchanan, CeciliaStigliano, Ivan DanielGaray Malpartida, H. M.Rodrigues Gomes, L.Puricelli, Lydia InesSogayar, M.C.Bal, Elisa DoraPeters, María GiselleAPOPTOSISBREAST CANCERGLYPICAN-3P38MAPK PATHWAYPI3K/AKT PATHWAYhttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Glypican-3 (GPC3) is a proteoglycan involved in proliferation and cell survival. Several reports demonstrated that GPC3 is downregulated in some tumors, such as breast cancer. Previously, we determined that GPC3 reexpression in the murine mammary adenocarcinoma LM3 cells induced an impairment of their invasive and metastatic capacities, associated with a decrease of their motility and an increase of their cell death. We demonstrated that GPC3 inhibits canonical Wnt signaling, as well as it activates non canonical pathway. Now, we identified signaling pathways responsible for the pro-apoptotic role of GPC3 in LM3 cells. We found for the first time that GPC3 inhibits the PI3K/Akt anti-apoptotic pathway while it stimulates the p38MAPK stress-activated one. We report a concomitant modulation of CDK inhibitors as well as of pro- and anti-apoptotic molecules. Our results provide new clues regarding the mechanism involved in the modulation induced by GPC3 of mammary tumor cell growth and survival.Fil: Buchanan, Cecilia. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología "Ángel H. Roffo"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; ArgentinaFil: Stigliano, Ivan Daniel. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología "Ángel H. Roffo"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; ArgentinaFil: Garay Malpartida, H. M.. Universidade de Sao Paulo; BrasilFil: Rodrigues Gomes, L.. Universidade de Sao Paulo; BrasilFil: Puricelli, Lydia Ines. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología "Ángel H. Roffo"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; ArgentinaFil: Sogayar, M.C.. Universidade de Sao Paulo; BrasilFil: Bal, Elisa Dora. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología "Ángel H. Roffo"; ArgentinaFil: Peters, María Giselle. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología "Ángel H. Roffo"; ArgentinaSpringer2010-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/117735Buchanan, Cecilia; Stigliano, Ivan Daniel; Garay Malpartida, H. M.; Rodrigues Gomes, L.; Puricelli, Lydia Ines; et al.; Glypican-3 reexpression regulates apoptosis in murine adenocarcinoma mammary cells modulating PI3K/Akt and p38MAPK signaling pathways; Springer; Breast Cancer Research and Treatment; 119; 3; 2-2010; 559-5740167-6806CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007/s10549-009-0362-9info:eu-repo/semantics/altIdentifier/doi/10.1007/s10549-009-0362-9info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2024-05-08T13:47:03Zoai:ri.conicet.gov.ar:11336/117735instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982024-05-08 13:47:03.275CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
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