Brucella abortus induces TNF-á-dependent astroglial MMP-9 secretion through mitogen-activated protein kinases

Central nervous system (CNS) invasion by bacteria of the genus Brucella results in an inflammatory disorder called neurobrucellosis. We have recently demonstrated that B. abortus infects microglia and astrocytes, eliciting the production of a variety of pro-inflammatory cytokines which contribute to...

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Detalhes bibliográficos
Autores: Miraglia, Maria Cruz, Scian, Romina, Garcia Samartino, Clara, Barrionuevo, Paula, Baldi, Pablo Cesar, Cassataro, Juliana, Delpino, María Victoria, Giambartolomei, Guillermo Hernan, Rodríguez, Ana María, Ibañez, Andres Esteban, Coria, Lorena, Velasquez, Lis Noelia
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2013
País:Argentina
Recursos:Consejo Nacional de Investigaciones Científicas y Técnicas
Repositorio:CONICET Digital (CONICET)
Idioma:inglés
OAI Identifier:oai:ri.conicet.gov.ar:11336/1240
Acesso em linha:http://hdl.handle.net/11336/1240
Access Level:acceso abierto
Palavra-chave:Brucella
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
Descrição
Resumo:Central nervous system (CNS) invasion by bacteria of the genus Brucella results in an inflammatory disorder called neurobrucellosis. We have recently demonstrated that B. abortus infects microglia and astrocytes, eliciting the production of a variety of pro-inflammatory cytokines which contribute to CNS damage. Matrix metalloproteinases (MMP) have been implicated in inflammatory tissue destruction in a range of pathological situations in the CNS. Increased MMP secretion is induced by pro-inflammatory cytokines in a variety of CNS diseases characterized by tissue-destructive pathology.

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