Melatonin normalizes clinical and biochemical parameters of mild inflammation in diet-induced metabolic syndrome in rats

The objective of this study was to evaluate the efficacy of melatonin to affect mild inflammation in the metabolic syndrome (MS) induced by a high-fat diet in rats. Adult Wistar male rats were divided into four groups (n = 16/group): (i) control diet (3% fat); (ii) high-fat (35%) diet; (iii) high-fa...

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Autores: Cano Barquilla, Pilar, Pagano, Eleonora Samanta, Jiménez Ortega, Vanesa, Fernández Mateos, Pilar, Esquifino, Ana I., Cardinali, Daniel Pedro
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2014
País:Argentina
Institución:Consejo Nacional de Investigaciones Científicas y Técnicas
Repositorio:CONICET Digital (CONICET)
Idioma:inglés
OAI Identifier:oai:ri.conicet.gov.ar:11336/30363
Acceso en línea:http://hdl.handle.net/11336/30363
Access Level:acceso abierto
Palabra clave:Cytokines
Dyslipidemia
Glucose Tolerance
High-Fat Diet
Hypertension
Inflammation
Uric Acid
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
id AR_0ac1e01fffffaec2fbeedd12cdf1e310
oai_identifier_str oai:ri.conicet.gov.ar:11336/30363
network_acronym_str AR
network_name_str Argentina
repository_id_str
dc.title.none.fl_str_mv Melatonin normalizes clinical and biochemical parameters of mild inflammation in diet-induced metabolic syndrome in rats
title Melatonin normalizes clinical and biochemical parameters of mild inflammation in diet-induced metabolic syndrome in rats
spellingShingle Melatonin normalizes clinical and biochemical parameters of mild inflammation in diet-induced metabolic syndrome in rats
Cano Barquilla, Pilar
Cytokines
Dyslipidemia
Glucose Tolerance
High-Fat Diet
Hypertension
Inflammation
Uric Acid
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
title_short Melatonin normalizes clinical and biochemical parameters of mild inflammation in diet-induced metabolic syndrome in rats
title_full Melatonin normalizes clinical and biochemical parameters of mild inflammation in diet-induced metabolic syndrome in rats
title_fullStr Melatonin normalizes clinical and biochemical parameters of mild inflammation in diet-induced metabolic syndrome in rats
title_full_unstemmed Melatonin normalizes clinical and biochemical parameters of mild inflammation in diet-induced metabolic syndrome in rats
title_sort Melatonin normalizes clinical and biochemical parameters of mild inflammation in diet-induced metabolic syndrome in rats
dc.creator.none.fl_str_mv Cano Barquilla, Pilar
Pagano, Eleonora Samanta
Jiménez Ortega, Vanesa
Fernández Mateos, Pilar
Esquifino, Ana I.
Cardinali, Daniel Pedro
author Cano Barquilla, Pilar
author_facet Cano Barquilla, Pilar
Pagano, Eleonora Samanta
Jiménez Ortega, Vanesa
Fernández Mateos, Pilar
Esquifino, Ana I.
Cardinali, Daniel Pedro
author_role author
author2 Pagano, Eleonora Samanta
Jiménez Ortega, Vanesa
Fernández Mateos, Pilar
Esquifino, Ana I.
Cardinali, Daniel Pedro
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Cytokines
Dyslipidemia
Glucose Tolerance
High-Fat Diet
Hypertension
Inflammation
Uric Acid
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
topic Cytokines
Dyslipidemia
Glucose Tolerance
High-Fat Diet
Hypertension
Inflammation
Uric Acid
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
description The objective of this study was to evaluate the efficacy of melatonin to affect mild inflammation in the metabolic syndrome (MS) induced by a high-fat diet in rats. Adult Wistar male rats were divided into four groups (n = 16/group): (i) control diet (3% fat); (ii) high-fat (35%) diet; (iii) high-fat diet + melatonin; and (iv) melatonin. Rats had free access to high-fat or control chow and one of the following drinking solutions for 10 wk: (a) tap water; (b) 25 μg/mL of melatonin. Plasma interleukin (IL)-1β, IL-4, IL-6, IL-10, tumor necrosis factor (TNF)-α, interferon (IFN)-γ, and C-reactive protein (CRP) were measured at two time intervals, that is, the middle of daylight period and the middle of the scotophase. In addition, a number of somatic and metabolic components employed clinically to monitor the MS were measured. Melatonin decreased the augmented circulating levels of IL-1β, IL-6, TNF-α, IFN-γ, and CRP seen in obese rats and restored the depressed levels of IL-4 and IL-10. Rats fed with the high-fat diet showed significantly higher body weights and augmented systolic blood pressure from the third and fourth week onwards, respectively, melatonin effectively preventing these changes. In high-fat-fed rats, circulating low-density lipoprotein-cholesterol, total cholesterol, and triglyceride concentration augmented significantly, melatonin being effective to counteract these changes. Melatonin-treated rats showed a decreased insulin resistance, the highest values of plasma high-density lipoprotein-cholesterol, and the lowest values of plasma uric acid. The results indicate that melatonin is able to normalize the altered biochemical pro-inflammatory profile seen in rats fed with a high-fat diet.
publishDate 2014
dc.date.none.fl_str_mv 2014-09
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/30363
Cano Barquilla, Pilar; Pagano, Eleonora Samanta; Jiménez Ortega, Vanesa; Fernández Mateos, Pilar; Esquifino, Ana I.; et al.; Melatonin normalizes clinical and biochemical parameters of mild inflammation in diet-induced metabolic syndrome in rats; Wiley; Journal of Pineal Research; 57; 3; 9-2014; 280-290
0742-3098
1600-079X
CONICET Digital
CONICET
url http://hdl.handle.net/11336/30363
identifier_str_mv Cano Barquilla, Pilar; Pagano, Eleonora Samanta; Jiménez Ortega, Vanesa; Fernández Mateos, Pilar; Esquifino, Ana I.; et al.; Melatonin normalizes clinical and biochemical parameters of mild inflammation in diet-induced metabolic syndrome in rats; Wiley; Journal of Pineal Research; 57; 3; 9-2014; 280-290
0742-3098
1600-079X
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1111/jpi.12168
info:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1111/jpi.12168/abstract
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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spelling Melatonin normalizes clinical and biochemical parameters of mild inflammation in diet-induced metabolic syndrome in ratsCano Barquilla, PilarPagano, Eleonora SamantaJiménez Ortega, VanesaFernández Mateos, PilarEsquifino, Ana I.Cardinali, Daniel PedroCytokinesDyslipidemiaGlucose ToleranceHigh-Fat DietHypertensionInflammationUric Acidhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3The objective of this study was to evaluate the efficacy of melatonin to affect mild inflammation in the metabolic syndrome (MS) induced by a high-fat diet in rats. Adult Wistar male rats were divided into four groups (n = 16/group): (i) control diet (3% fat); (ii) high-fat (35%) diet; (iii) high-fat diet + melatonin; and (iv) melatonin. Rats had free access to high-fat or control chow and one of the following drinking solutions for 10 wk: (a) tap water; (b) 25 μg/mL of melatonin. Plasma interleukin (IL)-1β, IL-4, IL-6, IL-10, tumor necrosis factor (TNF)-α, interferon (IFN)-γ, and C-reactive protein (CRP) were measured at two time intervals, that is, the middle of daylight period and the middle of the scotophase. In addition, a number of somatic and metabolic components employed clinically to monitor the MS were measured. Melatonin decreased the augmented circulating levels of IL-1β, IL-6, TNF-α, IFN-γ, and CRP seen in obese rats and restored the depressed levels of IL-4 and IL-10. Rats fed with the high-fat diet showed significantly higher body weights and augmented systolic blood pressure from the third and fourth week onwards, respectively, melatonin effectively preventing these changes. In high-fat-fed rats, circulating low-density lipoprotein-cholesterol, total cholesterol, and triglyceride concentration augmented significantly, melatonin being effective to counteract these changes. Melatonin-treated rats showed a decreased insulin resistance, the highest values of plasma high-density lipoprotein-cholesterol, and the lowest values of plasma uric acid. The results indicate that melatonin is able to normalize the altered biochemical pro-inflammatory profile seen in rats fed with a high-fat diet.Fil: Cano Barquilla, Pilar. Universidad Complutense de Madrid; EspañaFil: Pagano, Eleonora Samanta. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires". Facultad de Ciencias Médicas. Departamento de Docencia e Investigación; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; ArgentinaFil: Jiménez Ortega, Vanesa. Universidad Complutense de Madrid; EspañaFil: Fernández Mateos, Pilar. Universidad Complutense de Madrid; EspañaFil: Esquifino, Ana I.. Universidad Complutense de Madrid; EspañaFil: Cardinali, Daniel Pedro. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires". Facultad de Ciencias Médicas. Departamento de Docencia e Investigación; Argentina. Universidad de Buenos Aires. Facultad de Medicina; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; ArgentinaWiley2014-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/30363Cano Barquilla, Pilar; Pagano, Eleonora Samanta; Jiménez Ortega, Vanesa; Fernández Mateos, Pilar; Esquifino, Ana I.; et al.; Melatonin normalizes clinical and biochemical parameters of mild inflammation in diet-induced metabolic syndrome in rats; Wiley; Journal of Pineal Research; 57; 3; 9-2014; 280-2900742-30981600-079XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1111/jpi.12168info:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1111/jpi.12168/abstractinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2024-05-08T13:32:39Zoai:ri.conicet.gov.ar:11336/30363instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982024-05-08 13:32:39.855CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
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