Antifungal activity of a novel quercetin derivative bearing a trifluoromethyl group on Candida albicans

In this study, a novel quercetin derivative bearing a trifluoromethyl group was synthesized by the nucleophilic aromatic substitution reaction between rutin and 2-chloro-5-(trifluoromethyl)-1,3-dinitrobenzene in basic medium. This synthetic quercetin showed antifungal activity against Candida albica...

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Detalhes bibliográficos
Autores: Tempesti, Tomas Cristian, Alvarez, María Gabriela, de Araújo, Marcelo Francisco, Catunda Júnior, Francisco Eduardo Aragão, de Carvalho, Mário Geraldo, Durantini, Edgardo Néstor
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2012
País:Argentina
Recursos:Consejo Nacional de Investigaciones Científicas y Técnicas
Repositorio:CONICET Digital (CONICET)
Idioma:inglés
OAI Identifier:oai:ri.conicet.gov.ar:11336/62845
Acesso em linha:http://hdl.handle.net/11336/62845
Access Level:acceso abierto
Palavra-chave:Antifungal Activity
Candida Albicans
Flavonoid
Quercetin
Rutin
https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
Descrição
Resumo:In this study, a novel quercetin derivative bearing a trifluoromethyl group was synthesized by the nucleophilic aromatic substitution reaction between rutin and 2-chloro-5-(trifluoromethyl)-1,3-dinitrobenzene in basic medium. This synthetic quercetin showed antifungal activity against Candida albicans cultures. The results indicated a remarkable increase in the biological activity of this compound as compared to rutin.

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