BtpB, a novel Brucella TIR-containing effector protein with immune modulatory functions.

Several bacterial pathogens have TIR domain-containing proteins that contribute to their pathogenesis. We identified a second TIR-containing protein in Brucella spp. that we have designated BtpB. We show it is a potent inhibitor of TLR signaling, probably via MyD88. BtpB is a novel Brucella effector...

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Detalles Bibliográficos
Autores: Salcedo, Suzana P., Marchesini, Maria Ines, Degos, Clara, Terwagne, Matthiew, Von Bargen, Kristine, Lepidi, Hubert, Herrmann, Claudia Karina, Santos Lacerda, Thais L., Imbert, Paul R. C., Pierre, Philippe, Alexopoulou, Lena, Letesson, Jean Jacques, Comerci, Diego José, Gorvel, Jean Pierre
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2013
País:Argentina
Institución:Consejo Nacional de Investigaciones Científicas y Técnicas
Repositorio:CONICET Digital (CONICET)
Idioma:inglés
OAI Identifier:oai:ri.conicet.gov.ar:11336/24837
Acceso en línea:http://hdl.handle.net/11336/24837
Access Level:acceso abierto
Palabra clave:BRUCELLA
TIR DOMAIN
TLR
DENDRITIC CELLS
Btp1/BtpA
DC
NF-κB
https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
Descripción
Sumario:Several bacterial pathogens have TIR domain-containing proteins that contribute to their pathogenesis. We identified a second TIR-containing protein in Brucella spp. that we have designated BtpB. We show it is a potent inhibitor of TLR signaling, probably via MyD88. BtpB is a novel Brucella effector that is translocated into host cells and interferes with activation of dendritic cells. In vivo mouse studies revealed that BtpB is contributing to virulence and control of local inflammatory responses with relevance in the establishment of chronic brucellosis. Together, our results show that BtpB is a novel Brucella effector that plays a major role in the modulation of host innate immune response during infection.

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