Effect of sex chromosome complement on sodium appetite and Fos-immunoreactivity induced by sodium depletion.

Effect of sex chromosome complement on sodium appetite and Fos-immunoreactivity induced by sodium depletion. Am J Physiol Regul Integr Comp Physiol 306: R175–R184, 2014. First published November 20, 2013; doi:10.1152/ajpregu.00447.2013.—Previous studies indicate a sex chromosome complement (SCC) eff...

Descripción completa

Detalles Bibliográficos
Autores: Dadam, F.M., Caeiro, X.E., Cisternas, C.D., Macchione, A.F., Vivas, L.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2014
País:Argentina
Institución:Universidad Nacional de Córdoba
Repositorio:Repositorio Digital Universitario (UNC)
Idioma:inglés
OAI Identifier:oai:rdu.unc.edu.ar:11086/4903
Acceso en línea:http://hdl.handle.net/11086/4903
Access Level:acceso abierto
Palabra clave:Sex chromosomes
Sex characteristics
Induced sodium intake
Fos-immunoreactivity
id AR_06df30ae7e75b42653c5e796644792ce
oai_identifier_str oai:rdu.unc.edu.ar:11086/4903
network_acronym_str AR
network_name_str Argentina
repository_id_str
spelling Effect of sex chromosome complement on sodium appetite and Fos-immunoreactivity induced by sodium depletion.Dadam, F.M.Caeiro, X.E.Cisternas, C.D.Macchione, A.F.Vivas, L.Sex chromosomesSex characteristicsInduced sodium intakeFos-immunoreactivityEffect of sex chromosome complement on sodium appetite and Fos-immunoreactivity induced by sodium depletion. Am J Physiol Regul Integr Comp Physiol 306: R175–R184, 2014. First published November 20, 2013; doi:10.1152/ajpregu.00447.2013.—Previous studies indicate a sex chromosome complement (SCC) effect on the angiotensin II-sexually dimorphic hypertensive and bradycardic baroreflex responses. We sought to evaluate whether SCC may differentially modulate sexually dimorphic-induced sodium appetite and specific brain activity due to physiological stimulation of the rennin angiotensin system. For this purpose, we used the “four core genotype” mouse model, in which the effect of gonadal sex and SCC is dissociated, allowing comparisons of sexually dimorphic traits between XX and XY females as well as in XX and XY males. Gonadectomized mice were sodium depleted by furosemide (50mg/kg) and low-sodium diet treatment; control groups were administered with vehicle and maintained on normal sodium diet. Twenty-one hours later, the mice were divided into two groups: one group was submitted to the water-2% NaCl choice intake test, while the other group was perfused and their brains subjected to the Fos-mmunoreactivity (FOS-ir) procedure. Sodium depletion, regardless of SCC (XX or XY), induced a significantly lower sodium and water intake in females than in males, confirming the existence in mice of sexual dimorphism in sodium appetite and the organizational envolvement of gonadal steroids. Moreover, our results demonstrate a SCC effect on induced brain FOS-ir, showing increased brain activity in XX-SCC mice at the paraventricular nucleus, nucleus of the solitary tract, and lateral parabrachial nucleus, as well as an XX-SCC augmented effect on sodium depletion-induced brain activity at two circumventricular organs, the subfornical organ and area postrema, nuclei closely involved in fluid and blood pressure homeostasis.publishedVersionAmerican Journal of Physiology-Regulatory, Integrative and Comparative Physiology.2014info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfDadam, F.M, Caeiro, X.E, Cisternas, C.D, Macchione, A.F, Cambiasso, M.J., Vivas, L. Effect of sex chromosome complement on sodium appetite and Fos-immunoreactivity induced by sodium depletion. Am J Physiol Regul Integr Comp Physiol. 2014;306(3): 175-184.1522-1490http://hdl.handle.net/11086/4903enginfo:eu-repo/semantics/openAccessreponame:Repositorio Digital Universitario (UNC)instname:Universidad Nacional de Córdobainstacron:UNC2024-05-15T12:54:25Zoai:rdu.unc.edu.ar:11086/4903Institucionalhttps://rdu.unc.edu.ar/Universidad públicaNo correspondehttp://rdu.unc.edu.ar/oai/snrdoca.unc@gmail.comArgentinaNo correspondeNo correspondeNo correspondeopendoar:25722024-05-15 12:54:25.348Repositorio Digital Universitario (UNC) - Universidad Nacional de Córdobafalse
dc.title.none.fl_str_mv Effect of sex chromosome complement on sodium appetite and Fos-immunoreactivity induced by sodium depletion.
title Effect of sex chromosome complement on sodium appetite and Fos-immunoreactivity induced by sodium depletion.
spellingShingle Effect of sex chromosome complement on sodium appetite and Fos-immunoreactivity induced by sodium depletion.
Dadam, F.M.
Sex chromosomes
Sex characteristics
Induced sodium intake
Fos-immunoreactivity
title_short Effect of sex chromosome complement on sodium appetite and Fos-immunoreactivity induced by sodium depletion.
title_full Effect of sex chromosome complement on sodium appetite and Fos-immunoreactivity induced by sodium depletion.
title_fullStr Effect of sex chromosome complement on sodium appetite and Fos-immunoreactivity induced by sodium depletion.
title_full_unstemmed Effect of sex chromosome complement on sodium appetite and Fos-immunoreactivity induced by sodium depletion.
title_sort Effect of sex chromosome complement on sodium appetite and Fos-immunoreactivity induced by sodium depletion.
dc.creator.none.fl_str_mv Dadam, F.M.
Caeiro, X.E.
Cisternas, C.D.
Macchione, A.F.
Vivas, L.
author Dadam, F.M.
author_facet Dadam, F.M.
Caeiro, X.E.
Cisternas, C.D.
Macchione, A.F.
Vivas, L.
author_role author
author2 Caeiro, X.E.
Cisternas, C.D.
Macchione, A.F.
Vivas, L.
author2_role author
author
author
author
dc.subject.none.fl_str_mv Sex chromosomes
Sex characteristics
Induced sodium intake
Fos-immunoreactivity
topic Sex chromosomes
Sex characteristics
Induced sodium intake
Fos-immunoreactivity
description Effect of sex chromosome complement on sodium appetite and Fos-immunoreactivity induced by sodium depletion. Am J Physiol Regul Integr Comp Physiol 306: R175–R184, 2014. First published November 20, 2013; doi:10.1152/ajpregu.00447.2013.—Previous studies indicate a sex chromosome complement (SCC) effect on the angiotensin II-sexually dimorphic hypertensive and bradycardic baroreflex responses. We sought to evaluate whether SCC may differentially modulate sexually dimorphic-induced sodium appetite and specific brain activity due to physiological stimulation of the rennin angiotensin system. For this purpose, we used the “four core genotype” mouse model, in which the effect of gonadal sex and SCC is dissociated, allowing comparisons of sexually dimorphic traits between XX and XY females as well as in XX and XY males. Gonadectomized mice were sodium depleted by furosemide (50mg/kg) and low-sodium diet treatment; control groups were administered with vehicle and maintained on normal sodium diet. Twenty-one hours later, the mice were divided into two groups: one group was submitted to the water-2% NaCl choice intake test, while the other group was perfused and their brains subjected to the Fos-mmunoreactivity (FOS-ir) procedure. Sodium depletion, regardless of SCC (XX or XY), induced a significantly lower sodium and water intake in females than in males, confirming the existence in mice of sexual dimorphism in sodium appetite and the organizational envolvement of gonadal steroids. Moreover, our results demonstrate a SCC effect on induced brain FOS-ir, showing increased brain activity in XX-SCC mice at the paraventricular nucleus, nucleus of the solitary tract, and lateral parabrachial nucleus, as well as an XX-SCC augmented effect on sodium depletion-induced brain activity at two circumventricular organs, the subfornical organ and area postrema, nuclei closely involved in fluid and blood pressure homeostasis.
publishDate 2014
dc.date.none.fl_str_mv 2014
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv Dadam, F.M, Caeiro, X.E, Cisternas, C.D, Macchione, A.F, Cambiasso, M.J., Vivas, L. Effect of sex chromosome complement on sodium appetite and Fos-immunoreactivity induced by sodium depletion. Am J Physiol Regul Integr Comp Physiol. 2014;306(3): 175-184.
1522-1490
http://hdl.handle.net/11086/4903
identifier_str_mv Dadam, F.M, Caeiro, X.E, Cisternas, C.D, Macchione, A.F, Cambiasso, M.J., Vivas, L. Effect of sex chromosome complement on sodium appetite and Fos-immunoreactivity induced by sodium depletion. Am J Physiol Regul Integr Comp Physiol. 2014;306(3): 175-184.
1522-1490
url http://hdl.handle.net/11086/4903
dc.language.none.fl_str_mv eng
language eng
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv American Journal of Physiology-Regulatory, Integrative and Comparative Physiology.
publisher.none.fl_str_mv American Journal of Physiology-Regulatory, Integrative and Comparative Physiology.
dc.source.none.fl_str_mv reponame:Repositorio Digital Universitario (UNC)
instname:Universidad Nacional de Córdoba
instacron:UNC
instname_str Universidad Nacional de Córdoba
instacron_str UNC
institution UNC
reponame_str Repositorio Digital Universitario (UNC)
collection Repositorio Digital Universitario (UNC)
repository.name.fl_str_mv Repositorio Digital Universitario (UNC) - Universidad Nacional de Córdoba
repository.mail.fl_str_mv oca.unc@gmail.com
_version_ 1799197163263098880
score 15.812429

Similares en LA Referencia