Pluripotent Stem Cells as a Robust Source of Mesenchymal Stem Cells
Mesenchymal stem cells (MSC) have been extensively studied over the past years for the treatment of different diseases. Most of the ongoing clinical trials currently involve the use of MSC derived from adult tissues. This source may have some limitations, particularly with therapies that may require...
| Autores: | , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2017 |
| País: | Argentina |
| Institución: | Consejo Nacional de Investigaciones Científicas y Técnicas |
| Repositorio: | CONICET Digital (CONICET) |
| Idioma: | inglés |
| OAI Identifier: | oai:ri.conicet.gov.ar:11336/40685 |
| Acceso en línea: | http://hdl.handle.net/11336/40685 |
| Access Level: | acceso abierto |
| Palabra clave: | Pluripotent Stem Cells Embryonic Stem Cells Cell Reprogramming Mesenchymal Stem Cells Mesenchymal Stromal Cells Differentiation Pluripotent-Derived Mesenchymal Stem Cells Ips-Derived Mesenchymal Stem Cells Epithelial-To-Mesenchymal Transition Emt https://purl.org/becyt/ford/1.6 https://purl.org/becyt/ford/1 |
| Sumario: | Mesenchymal stem cells (MSC) have been extensively studied over the past years for the treatment of different diseases. Most of the ongoing clinical trials currently involve the use of MSC derived from adult tissues. This source may have some limitations, particularly with therapies that may require extensive and repetitive cell dosage. However, nowadays, there is a staggering growth in literature on a new source of MSC. There is now increasing evidence about the mesenchymal differentiation from pluripotent stem cell (PSC). Here, we summarize the current knowledge of pluripotent-derived mesenchymal stem cells (PD-MSC). We present a historical perspective on the subject, and then discuss some critical questions that remain unanswered. |
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