Role played by the programmed death-1-programmed death ligand pathway during innate immunity against Mycobacterium tuberculosis

Tuberculous pleurisy allows the study of specific cells at the site of Mycobacterium tuberculosis infection. Among pleural lymphocytes, natural killer (NK) cells are a major source of interferon γ (IFN-γ), and their functions are regulated by activating and inhibitory receptors. Programmed death-1 (...

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Autores: Alvarez, Ivana Belén, Pasquinelli, Virginia, Jurado, Javier Oscar, Abbate, Pablo Eduardo, Musella, Rosa María, de la Barrera, Silvia Susana, García, Verónica Edith
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2010
País:Argentina
Institución:Consejo Nacional de Investigaciones Científicas y Técnicas
Repositorio:CONICET Digital (CONICET)
Idioma:inglés
OAI Identifier:oai:ri.conicet.gov.ar:11336/66505
Acceso en línea:http://hdl.handle.net/11336/66505
Access Level:acceso abierto
Palabra clave:Tuberculosis
Innate Immunity
Costimulation
Nk Cells
https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
id AR_0477dc8020db8f28ba35c19e4ffa4f90
oai_identifier_str oai:ri.conicet.gov.ar:11336/66505
network_acronym_str AR
network_name_str Argentina
repository_id_str
dc.title.none.fl_str_mv Role played by the programmed death-1-programmed death ligand pathway during innate immunity against Mycobacterium tuberculosis
title Role played by the programmed death-1-programmed death ligand pathway during innate immunity against Mycobacterium tuberculosis
spellingShingle Role played by the programmed death-1-programmed death ligand pathway during innate immunity against Mycobacterium tuberculosis
Alvarez, Ivana Belén
Tuberculosis
Innate Immunity
Costimulation
Nk Cells
https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
title_short Role played by the programmed death-1-programmed death ligand pathway during innate immunity against Mycobacterium tuberculosis
title_full Role played by the programmed death-1-programmed death ligand pathway during innate immunity against Mycobacterium tuberculosis
title_fullStr Role played by the programmed death-1-programmed death ligand pathway during innate immunity against Mycobacterium tuberculosis
title_full_unstemmed Role played by the programmed death-1-programmed death ligand pathway during innate immunity against Mycobacterium tuberculosis
title_sort Role played by the programmed death-1-programmed death ligand pathway during innate immunity against Mycobacterium tuberculosis
dc.creator.none.fl_str_mv Alvarez, Ivana Belén
Pasquinelli, Virginia
Jurado, Javier Oscar
Abbate, Pablo Eduardo
Musella, Rosa María
de la Barrera, Silvia Susana
García, Verónica Edith
author Alvarez, Ivana Belén
author_facet Alvarez, Ivana Belén
Pasquinelli, Virginia
Jurado, Javier Oscar
Abbate, Pablo Eduardo
Musella, Rosa María
de la Barrera, Silvia Susana
García, Verónica Edith
author_role author
author2 Pasquinelli, Virginia
Jurado, Javier Oscar
Abbate, Pablo Eduardo
Musella, Rosa María
de la Barrera, Silvia Susana
García, Verónica Edith
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Tuberculosis
Innate Immunity
Costimulation
Nk Cells
https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
topic Tuberculosis
Innate Immunity
Costimulation
Nk Cells
https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
description Tuberculous pleurisy allows the study of specific cells at the site of Mycobacterium tuberculosis infection. Among pleural lymphocytes, natural killer (NK) cells are a major source of interferon γ (IFN-γ), and their functions are regulated by activating and inhibitory receptors. Programmed death-1 (PD-1), programmed death ligand 1 (PD-L1), and programmed death ligand 2 (PD-L2) are recognized inhibitory receptors in adaptive immunity, but their role during innate immunity remains poorly understood. We investigated the PD-1:PDL1/ PD-L2 pathway on NK cell effector functions in peripheral blood and pleural fluid from patients with tuberculosis. M. tuberculosis stimulation significantly up-regulated PD-1, PD-L1, and PD-L2 levels on NK cells. Interestingly, a direct correlation between PD-1 and IFN-γ expression on NK cells was observed. Moreover, blockade of the PD-1 pathway markedly augmented lytic degranulation and IFN-γ production of NK cells against M. tuberculosis. Furthermore, PD-1+ NK cells displayed a diminished IFN-γ mean fluorescence intensity, denoting the relevance of PD-1 on IFN-γ regulation. Together, we described a novel inhibitory role played by PD-1:PD-L interactions in innate immunity in tuberculosis. © 2010 by the Infectious Diseases Society of America.
publishDate 2010
dc.date.none.fl_str_mv 2010-08
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/66505
Alvarez, Ivana Belén; Pasquinelli, Virginia; Jurado, Javier Oscar; Abbate, Pablo Eduardo; Musella, Rosa María; et al.; Role played by the programmed death-1-programmed death ligand pathway during innate immunity against Mycobacterium tuberculosis; University of Chicago Press; Journal Of Infectious Diseases; 202; 4; 8-2010; 524-532
0022-1899
CONICET Digital
CONICET
url http://hdl.handle.net/11336/66505
identifier_str_mv Alvarez, Ivana Belén; Pasquinelli, Virginia; Jurado, Javier Oscar; Abbate, Pablo Eduardo; Musella, Rosa María; et al.; Role played by the programmed death-1-programmed death ligand pathway during innate immunity against Mycobacterium tuberculosis; University of Chicago Press; Journal Of Infectious Diseases; 202; 4; 8-2010; 524-532
0022-1899
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1086/654932
info:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/jid/article/202/4/524/2192187
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv University of Chicago Press
publisher.none.fl_str_mv University of Chicago Press
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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spelling Role played by the programmed death-1-programmed death ligand pathway during innate immunity against Mycobacterium tuberculosisAlvarez, Ivana BelénPasquinelli, VirginiaJurado, Javier OscarAbbate, Pablo EduardoMusella, Rosa Maríade la Barrera, Silvia SusanaGarcía, Verónica EdithTuberculosisInnate ImmunityCostimulationNk Cellshttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Tuberculous pleurisy allows the study of specific cells at the site of Mycobacterium tuberculosis infection. Among pleural lymphocytes, natural killer (NK) cells are a major source of interferon γ (IFN-γ), and their functions are regulated by activating and inhibitory receptors. Programmed death-1 (PD-1), programmed death ligand 1 (PD-L1), and programmed death ligand 2 (PD-L2) are recognized inhibitory receptors in adaptive immunity, but their role during innate immunity remains poorly understood. We investigated the PD-1:PDL1/ PD-L2 pathway on NK cell effector functions in peripheral blood and pleural fluid from patients with tuberculosis. M. tuberculosis stimulation significantly up-regulated PD-1, PD-L1, and PD-L2 levels on NK cells. Interestingly, a direct correlation between PD-1 and IFN-γ expression on NK cells was observed. Moreover, blockade of the PD-1 pathway markedly augmented lytic degranulation and IFN-γ production of NK cells against M. tuberculosis. Furthermore, PD-1+ NK cells displayed a diminished IFN-γ mean fluorescence intensity, denoting the relevance of PD-1 on IFN-γ regulation. Together, we described a novel inhibitory role played by PD-1:PD-L interactions in innate immunity in tuberculosis. © 2010 by the Infectious Diseases Society of America.Fil: Alvarez, Ivana Belén. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; ArgentinaFil: Pasquinelli, Virginia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; ArgentinaFil: Jurado, Javier Oscar. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; ArgentinaFil: Abbate, Pablo Eduardo. Gobierno de la Ciudad de Buenos Aires. Hospital de Infecciosas "Dr. Francisco Javier Muñiz"; ArgentinaFil: Musella, Rosa María. Gobierno de la Ciudad de Buenos Aires. Hospital de Infecciosas "Dr. Francisco Javier Muñiz"; ArgentinaFil: de la Barrera, Silvia Susana. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Academia Nacional de Medicina de Buenos Aires. Instituto de Investigaciones Hematológicas "Mariano R. Castex". Departamento de Inmunología y Medicina Experimental; ArgentinaFil: García, Verónica Edith. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; ArgentinaUniversity of Chicago Press2010-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/66505Alvarez, Ivana Belén; Pasquinelli, Virginia; Jurado, Javier Oscar; Abbate, Pablo Eduardo; Musella, Rosa María; et al.; Role played by the programmed death-1-programmed death ligand pathway during innate immunity against Mycobacterium tuberculosis; University of Chicago Press; Journal Of Infectious Diseases; 202; 4; 8-2010; 524-5320022-1899CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1086/654932info:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/jid/article/202/4/524/2192187info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2024-05-08T14:13:43Zoai:ri.conicet.gov.ar:11336/66505instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982024-05-08 14:13:43.747CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
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